Mutations in PBP2 from ceftriaxone-resistant Neisseria gonorrhoeae alter the dynamics of the [beta]3

Fenton, Benjamin A.; Tomberg, Joshua; Sciandra, Carly A.; Nicholas, Robert A.; Davies, Christopher; Zhou, Pei

doi:10.1016/j.jbc.2021.101188

Mutations in PBP2 from ceftriaxone-resistant Neisseria gonorrhoeae alter the dynamics of the [beta]3

Journal Article · 01 October 2021 · J. Biol. Chem.

DOI:https://doi.org/10.1016/j.jbc.2021.101188· OSTI ID:1828034

Fenton, Benjamin A.; Tomberg, Joshua; Sciandra, Carly A.; Nicholas, Robert A.; Davies, Christopher; Zhou, Pei

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; NIGMS; National Institutes of Health (NIH)

OSTI ID:: 1828034

Journal Information:: J. Biol. Chem., Vol. 297, Issue (4)

Country of Publication:: United States

Language:: ENGLISH

References (35)

Global Estimates of the Prevalence and Incidence of Four Curable Sexually Transmitted Infections in 2012 Based on Systematic Review and Global Reporting Newman, Lori; Rowley, Jane; Vander Hoorn, Stephen PLOS ONE, Vol. 10, Issue 12 https://doi.org/10.1371/journal.pone.0143304	journal	December 2015
Gonorrhea – an evolving disease of the new millennium Hill, Stuart A.; Masters, Thao L.; Wachter, Jenny Microbial Cell, Vol. 3, Issue 9 https://doi.org/10.15698/mic2016.09.524	journal	September 2016
World Health Organization Global Gonococcal Antimicrobial Surveillance Program (WHO GASP): review of new data and evidence to inform international collaborative actions and research efforts Unemo, Magnus; Lahra, Monica M.; Cole, Michelle Sexual Health, Vol. 16, Issue 5 https://doi.org/10.1071/SH19023	journal	January 2019
2012 European guideline on the diagnosis and treatment of gonorrhoea in adults Bignell, C.; Unemo, M.; Radcliffe, Keith International Journal of STD & AIDS, Vol. 24, Issue 2 https://doi.org/10.1177/0956462412472837	journal	February 2013
Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018 Eyre, David W.; Sanderson, Nicholas D.; Lord, Emily Eurosurveillance, Vol. 23, Issue 27 https://doi.org/10.2807/1560-7917.ES.2018.23.27.1800323	journal	July 2018
Genetic characterisation of Neisseria gonorrhoeae resistant to both ceftriaxone and azithromycin Whiley, David M.; Jennison, Amy; Pearson, Julie The Lancet Infectious Diseases, Vol. 18, Issue 7 https://doi.org/10.1016/S1473-3099(18)30340-2	journal	July 2018
Update to CDC's Treatment Guidelines for Gonococcal Infection, 2020 St. Cyr, Sancta; Barbee, Lindley; Workowski, Kimberly A. MMWR. Morbidity and Mortality Weekly Report, Vol. 69, Issue 50 https://doi.org/10.15585/mmwr.mm6950a6	journal	December 2020
Genetics of Chromosomally Mediated Intermediate Resistance to Ceftriaxone and Cefixime in Neisseria gonorrhoeae Zhao, Shuqing; Duncan, Margaret; Tomberg, Joshua Antimicrobial Agents and Chemotherapy, Vol. 53, Issue 9 https://doi.org/10.1128/AAC.00304-09	journal	June 2009
Penicillin Binding Proteins: key players in bacterial cell cycle and drug resistance processes Macheboeuf, Pauline; Contreras-Martel, Carlos; Job, Viviana FEMS Microbiology Reviews, Vol. 30, Issue 5 https://doi.org/10.1111/j.1574-6976.2006.00024.x	journal	September 2006
The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis Sauvage, Eric; Kerff, Frédéric; Terrak, Mohammed FEMS Microbiology Reviews, Vol. 32, Issue 2 https://doi.org/10.1111/j.1574-6976.2008.00105.x	journal	March 2008
Hybrid penicillin-binding proteins in penicillin-resistant strains of Neisseria gonorrhoeae Spratt, Brian G. Nature, Vol. 332, Issue 6160 https://doi.org/10.1038/332173a0	journal	March 1988
Is Neisseria gonorrhoeae Initiating a Future Era of Untreatable Gonorrhea?: Detailed Characterization of the First Strain with High-Level Resistance to Ceftriaxone Ohnishi, Makoto; Golparian, Daniel; Shimuta, Ken Antimicrobial Agents and Chemotherapy, Vol. 55, Issue 7 https://doi.org/10.1128/AAC.00325-11	journal	May 2011
Ceftriaxone-Resistant Neisseria gonorrhoeae , Japan Ohnishi, Makoto; Saika, Takeshi; Hoshina, Shinji Emerging Infectious Diseases, Vol. 17, Issue 1 https://doi.org/10.3201/eid1701.100397	journal	January 2011
Molecular and Structural Analysis of Mosaic Variants of Penicillin-Binding Protein 2 Conferring Decreased Susceptibility to Expanded-Spectrum Cephalosporins in Neisseria gonorrhoeae : Role of Epistatic Mutations Tomberg, Joshua; Unemo, Magnus; Davies, Christopher Biochemistry, Vol. 49, Issue 37 https://doi.org/10.1021/bi101167x	journal	September 2010
Identification of Amino Acids Conferring High-Level Resistance to Expanded-Spectrum Cephalosporins in the penA Gene from Neisseria gonorrhoeae Strain H041 Tomberg, Joshua; Unemo, Magnus; Ohnishi, Makoto Antimicrobial Agents and Chemotherapy, Vol. 57, Issue 7 https://doi.org/10.1128/AAC.00093-13	journal	April 2013
Recognition of the β-lactam carboxylate triggers acylation of Neisseria gonorrhoeae penicillin-binding protein 2 Singh, Avinash; Tomberg, Joshua; Nicholas, Robert A. Journal of Biological Chemistry, Vol. 294, Issue 38 https://doi.org/10.1074/jbc.RA119.009942	journal	July 2019
Mutations in penicillin-binding protein 2 from cephalosporin-resistant Neisseria gonorrhoeae hinder ceftriaxone acylation by restricting protein dynamics Singh, Avinash; Turner, Jonathan M.; Tomberg, Joshua Journal of Biological Chemistry, Vol. 295, Issue 21 https://doi.org/10.1074/jbc.RA120.012617	journal	May 2020
Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic Resistance Powell, Ailsa J.; Tomberg, Joshua; Deacon, Ashley M. Journal of Biological Chemistry, Vol. 284, Issue 2 https://doi.org/10.1074/jbc.M805761200	journal	November 2008
Structural Effect of the Asp345a Insertion in Penicillin-Binding Protein 2 from Penicillin-Resistant Strains of Neisseria gonorrhoeae Fedarovich, Alena; Cook, Edward; Tomberg, Joshua Biochemistry, Vol. 53, Issue 48 https://doi.org/10.1021/bi5011317	journal	November 2014
A comparison of chemical shift sensitivity of trifluoromethyl tags: optimizing resolution in 19F NMR studies of proteins Ye, Libin; Larda, Sacha Thierry; Frank Li, Yi Feng Journal of Biomolecular NMR, Vol. 62, Issue 1 https://doi.org/10.1007/s10858-015-9922-y	journal	March 2015
Biased Signaling Pathways in 2-Adrenergic Receptor Characterized by 19F-NMR Liu, J. J.; Horst, R.; Katritch, V. Science, Vol. 335, Issue 6072 https://doi.org/10.1126/science.1215802	journal	January 2012
Using NMR spectroscopy to elucidate the role of molecular motions in enzyme function Lisi, George P.; Patrick Loria, J. Progress in Nuclear Magnetic Resonance Spectroscopy, Vol. 92-93 https://doi.org/10.1016/j.pnmrs.2015.11.001	journal	February 2016
Histidine−Aromatic Interactions in Proteins and Protein−Ligand Complexes: Quantum Chemical Study of X-ray and Model Structures Cauët, Emilie; Rooman, Marianne; Wintjens, René Journal of Chemical Theory and Computation, Vol. 1, Issue 3 https://doi.org/10.1021/ct049875k	journal	March 2005
On the Value of c : Can Low Affinity Systems Be Studied by Isothermal Titration Calorimetry? Turnbull, W. Bruce; Daranas, Antonio H. Journal of the American Chemical Society, Vol. 125, Issue 48 https://doi.org/10.1021/ja036166s	journal	December 2003
Conformational states dynamically populated by a kinase determine its function Xie, Tao; Saleh, Tamjeed; Rossi, Paolo Science, Vol. 370, Issue 6513 https://doi.org/10.1126/science.abc2754	journal	October 2020
Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease Cai, Yufeng; Myint, Wazo; Paulsen, Janet L. Journal of Chemical Theory and Computation, Vol. 10, Issue 8 https://doi.org/10.1021/ct4010454	journal	June 2014
The interplay of structure and dynamics: Insights from a survey of HIV-1 reverse transcriptase crystal structures: Structure and Dynamics of HIV RT Seckler, James M.; Leioatts, Nicholas; Miao, Hongyu Proteins: Structure, Function, and Bioinformatics, Vol. 81, Issue 10 https://doi.org/10.1002/prot.24325	journal	August 2013
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance Hare, S.; Vos, A. M.; Clayton, R. F. Proceedings of the National Academy of Sciences, Vol. 107, Issue 46 https://doi.org/10.1073/pnas.1010246107	journal	October 2010
Examining the role of protein structural dynamics in drug resistance in Mycobacterium tuberculosis Shaw, Daniel J.; Hill, Rachel E.; Simpson, Niall Chemical Science, Vol. 8, Issue 12 https://doi.org/10.1039/C7SC03336B	journal	January 2017
Comparison of SUMO fusion technology with traditional gene fusion systems: Enhanced expression and solubility with SUMO Marblestone, J. G. Protein Science, Vol. 15, Issue 1 https://doi.org/10.1110/ps.051812706	journal	January 2006
NMRPipe: A multidimensional spectral processing system based on UNIX pipes Delaglio, Frank; Grzesiek, Stephan; Vuister, GeertenW. Journal of Biomolecular NMR, Vol. 6, Issue 3 https://doi.org/10.1007/BF00197809	journal	November 1995
XDS Kabsch, Wolfgang Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2 https://doi.org/10.1107/S0907444909047337	journal	January 2010
PHENIX: a comprehensive Python-based system for macromolecular structure solution Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221 https://doi.org/10.1107/S0907444909052925	journal	January 2010
Coot model-building tools for molecular graphics Emsley, Paul; Cowtan, Kevin Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132 https://doi.org/10.1107/S0907444904019158	journal	November 2004
electronic Ligand Builder and Optimization Workbench ( eLBOW ): a tool for ligand coordinate and restraint generation Moriarty, Nigel W.; Grosse-Kunstleve, Ralf W.; Adams, Paul D. Acta Crystallographica Section D Biological Crystallography, Vol. 65, Issue 10 https://doi.org/10.1107/S0907444909029436	journal	September 2009

Similar Records

Mutations in PBP2 from ceftriaxone-resistant Neisseria gonorrhoeae alter the dynamics of the [beta]3

Journal Article · 2021 · J. Biol. Chem. · OSTI ID:1828934

Fenton, Benjamin A.; Tomberg, Joshua; Sciandra, Carly A.; +3 more

Mutations in penicillin-binding protein 2 from cephalosporin-resistant Neisseria gonorrhoeae hinder ceftriaxone acylation by restricting protein dynamics

Journal Article · 2020 · Journal of Biological Chemistry · OSTI ID:1637961

Singh, Avinash; Turner, Jonathan M.; Tomberg, Joshua; +4 more

Alanine 501 Mutations in Penicillin-Binding Protein 2 from Neisseria gonorrhoeae: Structure, Mechanism, and Effects on Cephalosporin Resistance and Biological Fitness

Journal Article · 2017 · Biochemistry · OSTI ID:1368253

Tomberg, Joshua; Fedarovich, Alena; Vincent, Leah R.; +4 more

Mutations in PBP2 from ceftriaxone-resistant Neisseria gonorrhoeae alter the dynamics of the [beta]3

Citation Formats

References (35)

Similar Records

Related Subjects