Cyanobacteriochromes active in the far-red to near-infrared

Patent · 01 June 2021

OSTI ID:1824015

Lagarias, John Clark; Rockwell, Nathan Clarke

The present invention provides a protein fusion construct comprising a far-red cyanobacteriochrome (CBCR) domain linked to a heterologous domain, wherein the far-red CBCR domain comprises a CBCR polypeptide and a tetrapyrrole chromophore. The invention also provides nucleic acids, expression cassettes, vectors, and host cells for expression of the far-red CBCR protein fusion constructs. Methods for detecting cellular components, methods for imaging biological structures, and method for modulating cellular processes using the protein fusion constructs are also provided.

• Research Organization: Univ. of California, Davis, CA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: SC0002395
• Assignee: The Regents of the University of California (Oakland, CA)
• Patent Number(s): 11,021,523
• Application Number: 16/109,613
• OSTI ID: 1824015
• Country of Publication: United States
• Language: English