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Insight into the function of active site residues in the catalytic mechanism of human ferrochelatase

Journal Article · · Biochem. J.
DOI:https://doi.org/10.1042/BCJ20210460· OSTI ID:1821727
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Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1821727
Journal Information:
Biochem. J., Vol. 478, Issue (17)
Country of Publication:
United States
Language:
ENGLISH

References (44)

Recognition of Anionic Porphyrins by DNA Aptamers journal January 1996
Toward an Efficient DNAzyme † journal May 1997
Porphyrin Metalation Catalyzed by a Small RNA Molecule journal January 1996
Antibody-catalyzed porphyrin metallation journal August 1990
A π-Helix Switch Selective for Porphyrin Deprotonation and Product Release in Human Ferrochelatase journal November 2007
Identification of the Mitochondrial Heme Metabolism Complex journal August 2015
C-Terminal Deletions in the ALAS2 Gene Lead to Gain of Function and Cause X-linked Dominant Protoporphyria without Anemia or Iron Overload journal September 2008
Erythropoietin signaling regulates heme biosynthesis journal May 2017
A Story of Chelatase Evolution: IDENTIFICATION AND CHARACTERIZATION OF A SMALL 13–15-kDa “ANCESTRAL” COBALTOCHELATASE (CbiX S ) IN THE ARCHAEA journal April 2003
Ferrochelatase at the millennium: structures, mechanisms and [2Fe-2S] clusters journal December 2000
Crystal structures and calorimetry reveal catalytically relevant binding mode of coproporphyrin and coproheme in coproporphyrin ferrochelatase journal December 2019
Metal Binding to Saccharomyces cerevisiae Ferrochelatase † journal November 2002
Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product journal January 2017
Substrate interactions with human ferrochelatase journal January 2007
Identification and Characterization of Solvent-Filled Channels in Human Ferrochelatase journal June 2012
Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis journal July 2010
Direct Measurement of Metal Ion Chelation in the Active Site of Human Ferrochelatase journal June 2007
Product Release Rather than Chelation Determines Metal Specificity for Ferrochelatase journal October 2009
Human Ferrochelatase:  Characterization of Substrate−Iron Binding and Proton-Abstracting Residues journal July 2001
Altered Orientation of Active Site Residues in Variants of Human Ferrochelatase. Evidence for a Hydrogen Bond Network Involved in Catalysis journal June 2007
The importance of porphyrin distortions for the ferrochelatase reaction journal February 2003
Dissection of Porphyrin-Induced Conformational Dynamics in the Heme Biosynthesis Enzyme Ferrochelatase journal August 2012
Structural analysis of heme proteins: implications for design and prediction journal January 2011
Noncanonical coproporphyrin-dependent bacterial heme biosynthesis pathway that does not use protoporphyrin journal February 2015
Isolation and characterization of visible light-sensitive mutants of Escherichia coli K12 journal June 1991
Characterization of a Bradyrhizobium japonicum ferrochelatase mutant and isolation of the hemH gene. journal January 1992
Bacterial ferrochelatase turns human: Tyr13 determines the apparent metal specificity of Bacillus subtilis ferrochelatase journal November 2010
Metal Ion Substrate Inhibition of Ferrochelatase journal July 2008
Porphyrin-substrate binding to murine ferrochelatase: effect on the thermal stability of the enzyme journal March 2005
Porphyrin Interactions with Wild-type and Mutant Mouse Ferrochelatase journal February 2000
Substitution of murine ferrochelatase glutamate-287 with glutamine or alanine leads to porphyrin substrate-bound variants journal May 2001
Probing the Active-site Residues in Saccharomyces cerevisiae Ferrochelatase by Directed Mutagenesis journal May 1996
Amino Acid Residues His183 and Glu264 in Bacillus subtilis Ferrochelatase Direct and Facilitate the Insertion of Metal Ion into Protoporphyrin IX † , ‡ journal January 2007
Direct proton magnetic resonance determination of the pKa of the active center histidine in thiolsubtilisin journal April 2002
The Cooperative Effect Between Active Site Ionized Groups and Water Desolvation Controls the Alteration of Acid/Base Catalysis in Serine Proteases journal August 2007
Production and characterization of erythropoietic protoporphyric heterodimeric ferrochelatases journal August 2005
Is it possible for Fe2+ to approach protoporphyrin IX from the side of Tyr-13 in Bacillus subtilis ferrochelatase? An answer from QM/MM study journal October 2012
Investigation by MD simulation of the key residues related to substrate-binding and heme-release in human ferrochelatase journal February 2013
Human Ferrochelatase: Insights for the Mechanism of Ferrous Iron Approaching Protoporphyrin IX by QM/MM and QTCP Free Energy Studies journal November 2016
Human ferrochelatase: crystallization, characterization of the [2Fe-2S] cluster and determination that the enzyme is a homodimer journal November 1999
Expression of human proteins at the Southeast Collaboratory for Structural Genomics journal March 2004
Bovine ferrochelatase. Kinetic analysis of inhibition by N-methylprotoporphyrin, manganese, and heme. journal October 1983
Version 1.2 of the Crystallography and NMR system journal October 2007
Features and development of Coot journal March 2010

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