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A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2?s Association with the HUSH

Journal Article · · ACS Chem. Biol.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1821724
Journal Information:
ACS Chem. Biol., Vol. 16, Issue (9)
Country of Publication:
United States
Language:
ENGLISH

References (53)

The language of covalent histone modifications January 2000
Linking the epigenetic ‘language’ of covalent histone modifications to cancer February 2004
Post-translational modifications and chromatin dynamics March 2019
Chromatin Modifications by Methylation and Ubiquitination: Implications in the Regulation of Gene Expression June 2006
Writing, erasing and reading histone lysine methylations April 2017
The diverse functions of histone lysine methylation November 2005
Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion September 2010
Structural Basis for Specific Binding of Human MPP8 Chromodomain to Histone H3 Methylated at Lysine 9 October 2011
Structural Insights for MPP8 Chromodomain Interaction with Histone H3 Lysine 9: Potential Effect of Phosphorylation on Methyl-Lysine Binding May 2011
The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes May 2018
Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells May 2015
ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex October 2016
Hyperactivation of HUSH complex function by Charcot–Marie–Tooth disease mutation in MORC2 June 2017
HUSH, a Link Between Intrinsic Immunity and HIV Latency February 2019
Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators December 2017
A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing April 2018
MPP 8 and SIRT 1 crosstalk in E‐cadherin gene silencing and epithelial–mesenchymal transition April 2015
MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a September 2011
Chemical probes for methyl lysine reader domains August 2016
A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1 January 2016
Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2 February 2017
Epigenetic protein families: a new frontier for drug discovery April 2012
Chromodomain Ligand Optimization via Target-Class Directed Combinatorial Repurposing July 2016
Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7 October 2019
Getting a handle on chemical probes of chomatin readers January 2020
Target class drug discovery September 2017
A General TR-FRET Assay Platform for High-Throughput Screening and Characterizing Inhibitors of Methyl-Lysine Reader Proteins April 2019
SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins April 2002
Dynamics and Memory of Heterochromatin in Living Cells June 2012
The HP1 chromo shadow domain binds a consensus peptide pentamer January 2000
Molecular Determinants for Targeting Heterochromatin Protein 1-Mediated Gene Silencing: Direct Chromoshadow Domain–KAP-1 Corepressor Interaction Is Essential September 2000
Pathway-Based High-Throughput Chemical Screen Identifies Compounds That Decouple Heterochromatin Transformations May 2019
Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication March 2006
HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor October 2012
A Map of General and Specialized Chromatin Readers in Mouse Tissues Generated by Label-free Interaction Proteomics January 2013
Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination December 2015
The Histone H3 Lysine 9 Methyltransferases G9a and GLP Regulate Polycomb Repressive Complex 2-Mediated Gene Silencing January 2014
Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells August 2015
TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control October 2020
Periphilin self-association underpins epigenetic silencing by the HUSH complex September 2020
ChromID identifies the protein interactome at chromatin marks March 2020
Practical aspects of using the microbatch method in screening conditions for protein crystallization November 2004
Integration, scaling, space-group assignment and post-refinement January 2010
Scaling and assessment of data quality December 2005
Phaser crystallographic software July 2007
CHAINSAW : a program for mutating pdb files used as templates in molecular replacement April 2008
Overview of the CCP 4 suite and current developments March 2011
Coot model-building tools for molecular graphics November 2004
Refinement of Macromolecular Structures by the Maximum-Likelihood Method May 1997
JLigand : a graphical tool for the CCP 4 template-restraint library March 2012
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix October 2019
Contribution of promoter DNA sequence to heterochromatin formation velocity and memory of gene repression in mouse embryo fibroblasts July 2019
Cavitation Enhancing Nanodroplets Mediate Efficient DNA Fragmentation in a Bench Top Ultrasonic Water Bath July 2015