Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Physical basis for distinct basal and mechanically gated activity of the human K[superscript +] chan

Journal Article · · Neuron
; ; ;

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science
OSTI ID:
1821720
Journal Information:
Neuron, Vol. 109, Issue (18)
Country of Publication:
United States
Language:
ENGLISH

References (52)

A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel July 2014
Hydrophobic Gating in Ion Channels January 2015
Multiple modalities converge on a common gate to control K 2P channel function: A common gate controls K 2P function July 2011
TREK-2, a New Member of the Mechanosensitive Tandem-pore K+ Channel Family June 2000
Maternally Inherited Birk Barel Mental Retardation Dysmorphism Syndrome Caused by a Mutation in the Genomically Imprinted Potassium Channel KCNK9 August 2008
Mutations in KCNK4 that Affect Gating Cause a Recognizable Neurodevelopmental Syndrome October 2018
Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels February 2019
Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel January 2012
Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel January 2013
Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K + channels February 2014
Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel December 2014
The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier November 2019
CHARMM: The biomolecular simulation program July 2009
TWIK1, a unique background channel with variable ion selectivity March 2012
A Novel Mechanism for Human K 2P 2.1 Channel Gating: FACILITATION OF C-TYPE GATING BY PROTONATION OF EXTRACELLULAR HISTIDINE RESIDUES May 2008
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac March 2015
Features and development of Coot March 2010
Molecular Background of Leak K + Currents: Two-Pore Domain Potassium Channels April 2010
Functional expression of TREK-2 K+ channel in cultured rat brain astrocytes March 2002
Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype August 2006
Automated Builder and Database of Protein/Membrane Complexes for Molecular Dynamics Simulations September 2007
CHARMM-GUI: A web-based graphical user interface for CHARMM March 2008
XDS January 2010
TREK-1 and TRAAK Are Principal K+ Channels at the Nodes of Ranvier for Rapid Action Potential Conduction on Mammalian Myelinated Afferent Nerves December 2019
Thermosensitivity of the two-pore domain K + channels TREK-2 and TRAAK: Thermosensitivity of TREK/TRAAK March 2005
CHAP: A Versatile Tool for the Structural and Functional Annotation of Ion Channel Pores August 2019
A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura September 2010
Structural basis for pH gating of the two-pore domain K+ channel TASK2 September 2020
Transmembrane Helix Straightening and Buckling Underlies Activation of Mechanosensitive and Thermosensitive K2P Channels December 2014
K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions October 2020
A Novel Channelopathy in Pulmonary Arterial Hypertension July 2013
TRAAK Is a Mammalian Neuronal Mechano-gated K+Channel January 1999
Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states May 2016
Phaser crystallographic software July 2007
Crystal Structure of the Human Two-Pore Domain Potassium Channel K2P1 January 2012
Assessment of Potential Stimuli for Mechano-Dependent Gating of MscL:  Effects of Pressure, Tension, and Lipid Headgroups † September 2005
Separate Gating Mechanisms Mediate the Regulation of K2P Potassium Channel TASK-2 by Intra- and Extracellular pH May 2010
The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception March 2009
Lipid-glass adhesion in giga-sealed patch-clamped membranes January 1994
A mammalian two pore domain mechano-gated S-like K+ channel August 1998
UCSF Chimera?A visualization system for exploratory research and analysis January 2004
The pore structure and gating mechanism of K2P channels: K2P channel gating August 2011
Much more than a leak: structure and function of K2P-channels March 2015
A lower X-gate in TASK channels traps inhibitors within the vestibule April 2020
Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK January 2019
Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue August 2009
A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels February 2016
Upregulation of K 2P 3.1 K + Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation July 2015
HOLE: A program for the analysis of the pore dimensions of ion channel structural models December 1996
Timing of CFTR Pore Opening and Structure of Its Transition State October 2015
Ultrasound activates mechanosensitive TRAAK K + channels through the lipid membrane February 2021
Type 2 Diabetes–Associated K + Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis August 2015

Similar Records

Related Subjects