Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Structural basis for glucocorticoid receptor recognition of both unmodified and methylated binding s

Journal Article · · Nucleic Acids Res.
DOI:https://doi.org/10.1093/nar/gkab605· OSTI ID:1820456

Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; NIH
OSTI ID:
1820456
Journal Information:
Nucleic Acids Res., Journal Name: Nucleic Acids Res. Journal Issue: (15) Vol. 49
Country of Publication:
United States
Language:
ENGLISH

References (66)

Synthetic STARR-seq reveals how DNA shape and sequence modulate transcriptional output and noise journal November 2018
GREAT improves functional interpretation of cis-regulatory regions journal May 2010
Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA journal August 1991
Methylated Cytosines Mutate to Transcription Factor Binding Sites that Drive Tetrapod Evolution journal October 2015
Cys2His2 Zinc Finger Methyl-CpG Binding Proteins: Getting a Handle on Methylated DNA journal March 2020
Genome-scale relationships between cytosine methylation and dinucleotide abundances in animals journal July 2008
Structural basis for effects of CpA modifications on C/EBPβ binding of DNA journal December 2018
DNA methylation: roles in mammalian development journal February 2013
Features and development of Coot journal March 2010
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
Determinants of Cell- and Gene-Specific Transcriptional Regulation by the Glucocorticoid Receptor journal June 2007
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
The structural basis of direct glucocorticoid-mediated transrepression journal December 2012
The African coelacanth genome provides insights into tetrapod evolution journal April 2013
MBD4 and TDG: Multifaceted DNA glycosylases with ever expanding biological roles journal March 2013
DNA methylation status predicts cell type-specific enhancer activity journal June 2011
Pervasive and CpG-dependent promoter-like characteristics of transcribed enhancers journal April 2020
The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals journal June 2013
ENCODE Data in the UCSC Genome Browser: year 5 update journal November 2012
The effects of cytosine methylation on general transcription factors journal July 2016
Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer journal February 2018
An integrated encyclopedia of DNA elements in the human genome journal September 2012
A new method of inference of ancestral nucleotide and amino acid sequences. journal December 1995
PDB_REDO: automated re-refinement of X-ray structure models in the PDB journal April 2009
DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity journal April 2009
The nuclear receptor superfamily: A structural perspective: The Nuclear Receptor Superfamily journal October 2018
Steroid Receptor Family: Structure and Functions journal May 1990
Epigenetics and Human Disease journal February 2016
Methyl-dependent and spatial-specific DNA recognition by the orthologous transcription factors human AP-1 and Epstein-Barr virus Zta journal February 2017
Impact of cytosine methylation on DNA binding specificities of human transcription factors journal May 2017
The oestrogen receptor recognizes an imperfectly palindromic response element through an alternative side-chain conformation journal February 1995
An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence journal October 2012
A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo journal January 2011
Quantitative Analysis of the DNA Methylation Sensitivity of Transcription Factor Complexes journal June 2017
c-Jun/c-Fos heterodimers regulate cellular genes via a newly identified class of methylated DNA sequence motifs journal December 2013
BEDTools: a flexible suite of utilities for comparing genomic features journal January 2010
DNAproDB: an interactive tool for structural analysis of DNA–protein complexes journal April 2017
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA journal June 1992
The structure of the nuclear hormone receptors journal May 1999
DNAshape: a method for the high-throughput prediction of DNA structural features on a genomic scale journal May 2013
Toward a Mechanistic Understanding of DNA Methylation Readout by Transcription Factors journal March 2020
X inactivation, differentiation, and DNA methylation journal January 1975
Studies of DNA methylation in animals journal January 1995
Evolution of Hormone-Receptor Complexity by Molecular Exploitation journal April 2006
DNA methylation and the frequency of CpG in animal DNA journal January 1980
Silencing chromatin: comparing modes and mechanisms journal January 2011
Crystal structure of the heterodimeric bZIP transcription factor c-Fos–c-Jun bound to DNA journal January 1995
Solution Structure of the Methyl-CpG Binding Domain of Human MBD1 in Complex with Methylated DNA journal May 2001
3DNA: a versatile, integrated software system for the analysis, rebuilding and visualization of three-dimensional nucleic-acid structures journal July 2008
Functions of DNA methylation: islands, start sites, gene bodies and beyond journal May 2012
Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism journal September 2008
MeCP2 Binding to DNA Depends upon Hydration at Methyl-CpG journal February 2008
Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space journal December 2015
A common mode of recognition for methylated CpG journal April 2013
Molecular basis of base substitution hotspots in Escherichia coli journal August 1978
Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes journal June 2017
DNA modification mechanisms and gene activity during development journal January 1975
Repair of naturally occurring mismatches can induce mutations in flanking DNA journal April 2014
BRG1 governs glucocorticoid receptor interactions with chromatin and pioneer factors across the genome journal May 2018
DNA Binding of the Glucocorticoid Receptor Is Not Essential for Survival journal May 1998
Evolution of Minimal Specificity and Promiscuity in Steroid Hormone Receptors journal November 2012
An anti‐inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation journal January 2011
Crystal Structure of an Ancient Protein: Evolution by Conformational Epistasis journal August 2007
CpG islands - ‘A rough guide’ journal April 2009
Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso journal September 2012
Glucocorticoid receptor signaling in health and disease journal September 2013

Similar Records

Structural basis for Klf4 recognition of methylated DNA
Journal Article · 2014 · Nucleic Acids Res. · OSTI ID:1131347

Structural Basis for Molecular Recognition at Serotonin Receptors
Journal Article · 2014 · Science · OSTI ID:1081343

Structural basis for σ1 receptor ligand recognition
Journal Article · 2018 · Nature Structural & Molecular Biology · OSTI ID:1502221

Related Subjects