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mechanotransduction channel of hair cells

Journal Article · · Neuron

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science
OSTI ID:
1818306
Journal Information:
Neuron, Vol. 109, Issue (13)
Country of Publication:
United States
Language:
ENGLISH

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Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function journal February 2002
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CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival journal December 2017
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TMC1 and TMC2 Are Components of the Mechanotransduction Channel in Hair Cells of the Mammalian Inner Ear journal August 2013
TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells journal August 2018
A Novel C-Terminal CIB2 (Calcium and Integrin Binding Protein 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family journal October 2015
Adaptation of Mammalian Auditory Hair Cell Mechanotransduction Is Independent of Calcium Entry journal November 2013
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Novel and recurrent CIB2 variants, associated with nonsyndromic deafness, do not affect calcium buffering and localization in hair cells journal July 2015
Ankyrin Is An Intracellular Tether for TMC Mechanotransduction Channels journal July 2020
Preferential Binding of Mg2+ Over Ca2+ to CIB2 Triggers an Allosteric Switch Impaired in Usher Syndrome Type 1J journal August 2018
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Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits journal December 2006
Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice journal December 2017
TMHS Is an Integral Component of the Mechanotransduction Machinery of Cochlear Hair Cells journal December 2012
Using injectoporation to deliver genes to mechanosensory hair cells journal September 2014
TMIE Is an Essential Component of the Mechanotransduction Machinery of Cochlear Hair Cells journal December 2014
Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function journal June 2016
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