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Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respi

Journal Article · · J. Med. Chem.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1815019
Journal Information:
J. Med. Chem., Vol. 64, Issue (14)
Country of Publication:
United States
Language:
ENGLISH

References (35)

A comparison of COVID-19, SARS and MERS January 2020
A new coronavirus associated with human respiratory disease in China February 2020
COVID-19: Drug Targets and Potential Treatments June 2020
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2): a global pandemic and treatment strategies August 2020
Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities November 2020
The SARS-CoV-2 main protease as drug target September 2020
Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design October 2020
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors April 2020
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors March 2020
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease April 2020
Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19 October 2020
SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model February 2021
Reprint of “On the Size of the Active Site in Proteases. I. Papain” August 2012
3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice August 2020
Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor March 2016
Applications of Deuterium in Medicinal Chemistry January 2019
Deuterated drugs; updates and obviousness analysis September 2017
N,N`-dissuccinimidyl carbonate: a useful reagent for alkoxycarbonylation of amines May 1992
A Novel, Nonaqueous Method for Regeneration of Aldehydes from Bisulfite Adducts July 1999
Curse or Cure? A Perspective on the Developability of Aldehydes as Active Pharmaceutical Ingredients September 2020
A primer of deuterium in drug design August 2019
Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design April 2011
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction March 2021
XDS January 2010
Data processing and analysis with the autoPROC toolbox March 2011
An introduction to data reduction: space-group determination, scaling and intensity statistics March 2011
Phaser crystallographic software July 2007
PHENIX: a comprehensive Python-based system for macromolecular structure solution January 2010
Features and development of Coot March 2010
MolProbity : all-atom structure validation for macromolecular crystallography December 2009
Scaling and assessment of data quality December 2005
Improved R-factors for diffraction data analysis in macromolecular crystallography April 1997
Global indicators of X-ray data quality April 2001
Linking Crystallographic Model and Data Quality May 2012
Resolving Some Old Problems in Protein Crystallography May 2012