Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Structural insights into the function of the catalytically active human Taspase1

Journal Article · · Structure

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; NCI; National Institutes of Health (NIH)
OSTI ID:
1814980
Journal Information:
Structure, Vol. 29, Issue (8)
Country of Publication:
United States
Language:
ENGLISH

References (62)

PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Preliminary crystal structure of Acinetobacter glutaminasificans glutaminase-asparaginase. journal January 1988
The road less traveled: modulating signal transduction enzymes by inhibiting their protein–protein interactions journal June 2009
Dynamics of a mobile loop at the active site of Escherichia coli asparaginase journal September 2000
Na + /K + exchange switches the catalytic apparatus of potassium-dependent plant L -asparaginase journal June 2014
The Importin-Alpha/Nucleophosmin Switch Controls Taspase1 Protease Function journal April 2011
Overexpression of the Catalytically Impaired Taspase1T234V or Taspase1D233A Variants Does Not Have a Dominant Negative Effect in T(4;11) Leukemia Cells journal May 2012
Allosteric inhibition of Taspase1′s pathobiological activity by enforced dimerization in vivo journal May 2012
Crystallization and preliminary crystallographic studies of a new L -asparaginase encoded by the Escherichia coli genome journal November 2000
Expression, purification and catalytic activity of Lupinus luteus asparagine β-amidohydrolase and its Escherichia coli homolog: Homologous L. luteus and E. coli amidohydrolases journal July 2004
A Pharmacologic Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth journal December 2011
Recent developments in classical density modification journal March 2010
MolProbity: all-atom contacts and structure validation for proteins and nucleic acids journal May 2007
An HMM model for coiled-coil domains and a comparison with PSSM-based predictions journal April 2002
MoRFpred, a computational tool for sequence-based prediction and characterization of short disorder-to-order transitioning binding regions in proteins journal June 2012
Features and development of Coot journal March 2010
Scaling and assessment of data quality journal December 2005
On the treatment of negative intensity observations journal July 1978
cisTEM, user-friendly software for single-particle image processing journal March 2018
Crystal Structures of Flavobacterium Glycosylasparaginase : AN N-TERMINAL NUCLEOPHILE HYDROLASE ACTIVATED BY INTRAMOLECULAR PROTEOLYSIS journal August 1998
Accurate Single-Sequence Prediction of Protein Intrinsic Disorder by an Ensemble of Deep Recurrent and Convolutional Architectures journal November 2018
Crystalline l-Asparaginase from Escherichia coli B journal July 1970
Taspase1 journal October 2003
Proteolytic Cleavage of MLL Generates a Complex of N- and C-Terminal Fragments That Confers Protein Stability and Subnuclear Localization journal January 2003
A solution for the best rotation to relate two sets of vectors journal September 1976
XDS journal January 2010
Crystal Structure of Human Taspase1, a Crucial Protease Regulating the Function of MLL journal October 2005
A time-resolved fluorescence resonance energy transfer assay suitable for high-throughput screening for inhibitors of immunoglobulin E–receptor interactions journal December 2012
MetaDisorder: a meta-server for the prediction of intrinsic disorder in proteins journal May 2012
Inference of Macromolecular Assemblies from Crystalline State journal September 2007
Intramolecular Cleavage of the hASRGL1 Homodimer Occurs in Two Stages journal February 2016
Biphasic MLL takes helm at cell cycle control: Implications in human mixed lineage leukemia journal February 2008
Opportunistic complexes of E. coli L-asparaginases with citrate anions journal July 2019
DeepCoil—a fast and accurate prediction of coiled-coil domains in protein sequences journal January 2019
Predicting coiled coils from protein sequences journal May 1991
Solving structures of protein complexes by molecular replacement with Phaser journal December 2006
Crystal packing of plant-type L -asparaginase from Escherichia coli journal February 2008
Crystal Structure of Isoaspartyl Aminopeptidase in Complex with l-Aspartate journal August 2005
Structural aspects of L-asparaginases, their friends and relations. journal December 2006
Refinement of Macromolecular Structures by the Maximum-Likelihood Method journal May 1997
Elucidation of the Specific Function of the Conserved Threonine Triad Responsible for Human l-Asparaginase Autocleavage and Substrate Hydrolysis journal June 2014
Structural comparison of Ntn-hydrolases journal January 2000
Three-dimensional structure of human lysosomal aspartylglucosaminidase journal December 1995
MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins journal November 2017
Structure of the isoaspartyl peptidase with L -asparaginase activity from Escherichia coli journal May 2004
Role of proteases in cancer: A review [English] journal October 2012
The synthetic peptide PFWT disrupts AF4–AF9 protein complexes and induces apoptosis in t(4;11) leukemia cells journal July 2004
Crystal structure of Escherichia coli L-asparaginase, an enzyme used in cancer therapy. journal February 1993
Proteolysis of MLL family proteins is essential for Taspase1-orchestrated cell cycle progression journal September 2006
Interfering with protein-protein interactions: Potential for cancer therapy journal June 2008
Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution journal July 2015
MOLREP an Automated Program for Molecular Replacement journal December 1997
Peptidyl Succinimidyl Peptides as Taspase 1 Inhibitors journal August 2014
Structural Characterization of the Loop at the Alpha-Subunit C-Terminus of the Mixed Lineage Leukemia Protein Activating Protease Taspase1 journal March 2016
Two-step Dimerization for Autoproteolysis to Activate Glycosylasparaginase journal November 2002
Patented inhibitors of p53–Mdm2 interaction (2006 – 2008) journal January 2010
Targeting the Oligomerization Domain of ETO Interferes with RUNX1/ETO Oncogenic Activity in t(8;21)-Positive Leukemic Cells journal March 2007
Structural Insights into the Mechanism of Intramolecular Proteolysis journal September 1999
Crystal structure of glycosylasparaginase from Flavobacterium meningosepticum journal March 1998
PONDR-FIT: A meta-predictor of intrinsically disordered amino acids journal April 2010
Molecular Imaging of Proteases in Cancer journal January 2009
Anomalous signal indicators in protein crystallography journal October 2005