Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains

Journal Article · · J. Med. Chem.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1810876
Journal Information:
J. Med. Chem., Vol. 64, Issue (9)
Country of Publication:
United States
Language:
ENGLISH

References (51)

Does protein aggregation drive postmitotic tissue degeneration? journal January 2021
Repurposing Diflunisal for Familial Amyloid Polyneuropathy: A Randomized Clinical Trial journal December 2013
Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade journal May 2012
Migalastat: A Review in Fabry Disease journal March 2019
A Phase 3 Randomized Trial of Voxelotor in Sickle Cell Disease journal August 2019
Immunoglobulin light chain amyloidosis journal December 2013
Systemic immunoglobulin light chain amyloidosis journal October 2018
Thermodynamic Instability of Human λ6 Light Chains:  Correlation with Fibrillogenicity journal October 1999
Thermodynamic and fibril formation studies of full length immunoglobulin light chain AL-09 and its germline protein using scan rate dependent thermal unfolding journal December 2015
Kinetic stability and sequence/structure studies of urine-derived Bence-Jones proteins from multiple myeloma and light chain amyloidosis patients journal November 2017
The Kinetic Stability of a Full-Length Antibody Light Chain Dimer Determines whether Endoproteolysis Can Release Amyloidogenic Variable Domains journal October 2016
Fatal amyloid formation in a patient’s antibody light chain is caused by a single point mutation journal March 2020
Molecular mechanism of amyloidogenic mutations in hypervariable regions of antibody light chains journal January 2021
Targeting protein aggregation for the treatment of degenerative diseases journal September 2015
Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38  MAPK pathway journal February 2010
Human amyloidogenic light chain proteins result in cardiac dysfunction, cell death, and early mortality in zebrafish journal July 2013
Incomplete Refolding of Antibody Light Chains to Non-Native, Protease-Sensitive Conformations Leads to Aggregation: A Mechanism of Amyloidogenesis in Patients? journal December 2017
Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity journal December 2017
Structure of a λ-type Bence-Jones protein at 3.5-Å resolution journal November 1973
The structure of an entire noncovalent immunoglobulin kappa light-chain dimer (Bence-Jones protein) reveals a weak and unusual constant domains association journal February 1999
Review: Immunoglobulin Light Chain Amyloidosis—The Archetype of Structural and Pathogenic Variability journal June 2000
Immunoglobulin light chain variable (V) region genes influence clinical presentation and outcome in light chain–associated amyloidosis (AL) journal May 2003
Cyclophosphamide-bortezomib-dexamethasone (CyBorD) produces rapid and complete hematologic response in patients with AL amyloidosis journal May 2012
One year follow up analysis of the phase 1a/b study of chimeric fibril-reactive monoclonal antibody 11-1F4 in patients with AL amyloidosis journal March 2019
Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain journal August 2014
Pharmacologic targeting of plasma cell endoplasmic reticulum proteostasis to reduce amyloidogenic light chain secretion journal February 2021
A prospective phase 2 trial of daratumumab in patients with previously treated systemic light-chain amyloidosis journal April 2020
Infusion of Light Chains From Patients With Cardiac Amyloidosis Causes Diastolic Dysfunction in Isolated Mouse Hearts journal October 2001
Treatment patterns and outcome following initial relapse or refractory disease in patients with systemic light chain amyloidosis journal April 2017
AL-Base: a visual platform analysis tool for the study of amyloidogenic immunoglobulin light chain sequences journal January 2009
Metabolism of Bence Jones Proteins* journal January 1964
Stabilization of amyloidogenic immunoglobulin light chains by small molecules journal April 2019
Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins journal August 2020
Acetylene Group, Friend or Foe in Medicinal Chemistry journal February 2020
Should the Incorporation of Structural Alerts be Restricted in Drug Design? An Analysis of Structure-Toxicity Trends with Aniline-Based Drugs journal December 2014
Role of domain interactions in the aggregation of full-length immunoglobulin light chains journal December 2018
Best Practices for Foundations in Molecular Simulations [Article v1.0] journal January 2019
Application of Fragment-Based Drug Discovery to Versatile Targets journal August 2020
Improving Drug Design: An Update on Recent Applications of Efficiency Metrics, Strategies for Replacing Problematic Elements, and Compounds in Nontraditional Drug Space journal March 2016
Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization journal July 2020
AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading journal January 2009
A semiempirical free energy force field with charge-based desolvation journal January 2007
Open Babel: An open chemical toolbox journal October 2011
Iterative partial equalization of orbital electronegativity—a rapid access to atomic charges journal January 1980
ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB journal July 2015
Fast, efficient generation of high-quality atomic charges. AM1-BCC model: II. Parameterization and validation journal October 2002
Comparison of simple potential functions for simulating liquid water journal July 1983
Discovery of coumarin-based selective aldehyde dehydrogenase 1A1 inhibitors with glucose metabolism improving activity journal February 2020
Fluorogenic diazaborine formation of semicarbazide with designed coumarin derivatives journal January 2017
An Efficient Synthesis of 1,3,7-Triazaspiro[4.4]Nonane-2,4-Dione Derivatives and Antimicrobial Activity Thereof journal May 2015
Microwave-assisted synthesis of functionalized spirohydantoins as 3-D privileged fragments for scouting the chemical space journal June 2016