Structural basis for the stereospecific inhibition of the dual proline/hydroxyproline catabolic enzy

Bogner, Alexandra N.; Stiers, Kyle M.; McKay, Cole M.; Becker, Donald F.; Tanner, John J.

doi:10.1002/pro.4131

Structural basis for the stereospecific inhibition of the dual proline/hydroxyproline catabolic enzy

Journal Article · 01 August 2021 · Protein Sci.

DOI:https://doi.org/10.1002/pro.4131· OSTI ID:1810868

Bogner, Alexandra N.; Stiers, Kyle M.; McKay, Cole M.; Becker, Donald F.; Tanner, John J.

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; National Institutes of Health (NIH)

OSTI ID:: 1810868

Journal Information:: Protein Sci., Vol. 30, Issue (8)

Country of Publication:: United States

Language:: ENGLISH

References (36)

Metabolism of Proline and the Hydroxyprolines Adams, Elijah; Frank, Leonard Annual Review of Biochemistry, Vol. 49, Issue 1 https://doi.org/10.1146/annurev.bi.49.070180.005041	journal	June 1980
Structural Biology of Proline Catabolic Enzymes Tanner, John J. Antioxidants & Redox Signaling, Vol. 30, Issue 4 https://doi.org/10.1089/ars.2017.7374	journal	February 2019
The Proline Cycle As a Potential Cancer Therapy Target Tanner, John J.; Fendt, Sarah-Maria; Becker, Donald F. Biochemistry, Vol. 57, Issue 25 https://doi.org/10.1021/acs.biochem.8b00215	journal	April 2018
Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses Phang, James M. Antioxidants & Redox Signaling, Vol. 30, Issue 4 https://doi.org/10.1089/ars.2017.7350	journal	February 2019
The Janus-like role of proline metabolism in cancer Burke, Lynsey; Guterman, Inna; Palacios Gallego, Raquel Cell Death Discovery, Vol. 6, Issue 1 https://doi.org/10.1038/s41420-020-00341-8	journal	October 2020
The metabolism of cancer cells during metastasis Bergers, Gabriele; Fendt, Sarah-Maria Nature Reviews Cancer, Vol. 21, Issue 3 https://doi.org/10.1038/s41568-020-00320-2	journal	January 2021
Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses Yoon, Kyong-Ah; Nakamura, Yusuke; Arakawa, Hirofumi Journal of Human Genetics, Vol. 49, Issue 3 https://doi.org/10.1007/s10038-003-0122-3	journal	February 2004
A model for p53-induced apoptosis Polyak, Kornelia; Xia, Yong; Zweier, Jay L. Nature, Vol. 389, Issue 6648 https://doi.org/10.1038/38525	journal	September 1997
Mutations in the Delta1-pyrroline 5-carboxylate dehydrogenase gene cause type II hyperprolinemia Geraghty, M. Human Molecular Genetics, Vol. 7, Issue 9 https://doi.org/10.1093/hmg/7.9.1411	journal	September 1998
Pharmacological Chaperones: Design and Development of New Therapeutic Strategies for the Treatment of Conformational Diseases Convertino, Marino; Das, Jhuma; Dokholyan, Nikolay V. ACS Chemical Biology, Vol. 11, Issue 6 https://doi.org/10.1021/acschembio.6b00195	journal	April 2016
ALDH4A1 is an atherosclerosis auto-antigen targeted by protective antibodies Lorenzo, Cristina; Delgado, Pilar; Busse, Christian E. Nature, Vol. 589, Issue 7841 https://doi.org/10.1038/s41586-020-2993-2	journal	December 2020
Incomplete proline catabolism drives premature sperm aging Yen, Chia‐An; Curran, Sean P. Aging Cell, Vol. 20, Issue 2 https://doi.org/10.1111/acel.13308	journal	January 2021
Loss of flavin adenine dinucleotide (FAD) impairs sperm function and male reproductive advantage in C. elegans Yen, Chia-An; Ruter, Dana L.; Turner, Christian D. eLife, Vol. 9 https://doi.org/10.7554/eLife.52899	journal	February 2020
4-Hydroxyproline metabolism and glyoxylate production: A target for substrate depletion in primary hyperoxaluria? Coulter-Mackie, M. B. Kidney International, Vol. 70, Issue 11 https://doi.org/10.1038/sj.ki.5001987	journal	December 2006
Aldehyde dehydrogenases: From eye crystallins to metabolic disease and cancer stem cells Vasiliou, Vasilis; Thompson, David C.; Smith, Clay Chemico-Biological Interactions, Vol. 202, Issue 1-3 https://doi.org/10.1016/j.cbi.2012.10.026	journal	February 2013
Structure, function, and mechanism of proline utilization A (PutA) Liu, Li-Kai; Becker, Donald F.; Tanner, John J. Archives of Biochemistry and Biophysics, Vol. 632 https://doi.org/10.1016/j.abb.2017.07.005	journal	October 2017
The Three-Dimensional Structural Basis of Type II Hyperprolinemia Srivastava, Dhiraj; Singh, Ranjan K.; Moxley, Michael A. Journal of Molecular Biology, Vol. 420, Issue 3 https://doi.org/10.1016/j.jmb.2012.04.010	journal	July 2012
Structural basis of substrate selectivity of Δ1-pyrroline-5-carboxylate dehydrogenase (ALDH4A1): Semialdehyde chain length Pemberton, Travis A.; Tanner, John J. Archives of Biochemistry and Biophysics, Vol. 538, Issue 1 https://doi.org/10.1016/j.abb.2013.07.024	journal	October 2013
Proline: Mother Nature's cryoprotectant applied to protein crystallography Pemberton, Travis A.; Still, Brady R.; Christensen, Emily M. Acta Crystallographica Section D Biological Crystallography, Vol. 68, Issue 8 https://doi.org/10.1107/S0907444912019580	journal	July 2012
Structural Studies of Yeast Δ ¹ -Pyrroline-5-carboxylate Dehydrogenase (ALDH4A1): Active Site Flexibility and Oligomeric State Pemberton, Travis A.; Srivastava, Dhiraj; Sanyal, Nikhilesh Biochemistry, Vol. 53, Issue 8 https://doi.org/10.1021/bi500048b	journal	February 2014
Structural determinants of substrate specificity in aldehyde dehydrogenases Riveros-Rosas, Héctor; González-Segura, Lilian; Julián-Sánchez, Adriana Chemico-Biological Interactions, Vol. 202, Issue 1-3 https://doi.org/10.1016/j.cbi.2012.11.015	journal	February 2013
Structural Basis for the Substrate Inhibition of Proline Utilization A by Proline Korasick, David; Pemberton, Travis; Arentson, Benjamin Molecules, Vol. 23, Issue 1 https://doi.org/10.3390/molecules23010032	journal	December 2017
Structural and Biochemical Characterization of Aldehyde Dehydrogenase 12, the Last Enzyme of Proline Catabolism in Plants Korasick, David A.; Končitíková, Radka; Kopečná, Martina Journal of Molecular Biology, Vol. 431, Issue 3 https://doi.org/10.1016/j.jmb.2018.12.010	journal	February 2019
Structural analysis of prolines and hydroxyprolines binding to the l-glutamate-γ-semialdehyde dehydrogenase active site of bifunctional proline utilization A Campbell, Ashley C.; Bogner, Alexandra N.; Mao, Yizi Archives of Biochemistry and Biophysics, Vol. 698 https://doi.org/10.1016/j.abb.2020.108727	journal	February 2021
Genetics of kidney stone disease Howles, Sarah A.; Thakker, Rajesh V. Nature Reviews Urology, Vol. 17, Issue 7 https://doi.org/10.1038/s41585-020-0332-x	journal	June 2020
Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria Summitt, Candice B.; Johnson, Lynnette C.; Jönsson, Thomas J. Biochemical Journal, Vol. 466, Issue 2 https://doi.org/10.1042/BJ20141159	journal	February 2015
Efficacy of Hydroxy-L-proline (HYP) analogs in the treatment of primary hyperoxaluria in Drosophila Melanogaster Yang, Huan; Male, Musa; Li, Yang BMC Nephrology, Vol. 19, Issue 1 https://doi.org/10.1186/s12882-018-0980-8	journal	July 2018
XDS Kabsch, Wolfgang Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2 https://doi.org/10.1107/S0907444909047337	journal	January 2010
How good are my data and what is the resolution? Evans, Philip R.; Murshudov, Garib N. Acta Crystallographica Section D Biological Crystallography, Vol. 69, Issue 7 https://doi.org/10.1107/S0907444913000061	journal	June 2013
PHENIX: a comprehensive Python-based system for macromolecular structure solution Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221 https://doi.org/10.1107/S0907444909052925	journal	January 2010
Towards automated crystallographic structure refinement with phenix.refine Afonine, Pavel V.; Grosse-Kunstleve, Ralf W.; Echols, Nathaniel Acta Crystallographica Section D Biological Crystallography, Vol. 68, Issue 4 https://doi.org/10.1107/S0907444912001308	journal	March 2012
Features and development of Coot Emsley, P.; Lohkamp, B.; Scott, W. G. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4 https://doi.org/10.1107/S0907444910007493	journal	March 2010
electronic Ligand Builder and Optimization Workbench ( eLBOW ): a tool for ligand coordinate and restraint generation Moriarty, Nigel W.; Grosse-Kunstleve, Ralf W.; Adams, Paul D. Acta Crystallographica Section D Biological Crystallography, Vol. 65, Issue 10 https://doi.org/10.1107/S0907444909029436	journal	September 2009
MolProbity : all-atom structure validation for macromolecular crystallography Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1 https://doi.org/10.1107/S0907444909042073	journal	December 2009
Validation of Structures in the Protein Data Bank Gore, Swanand; Sanz García, Eduardo; Hendrickx, Pieter M. S. Structure, Vol. 25, Issue 12 https://doi.org/10.1016/j.str.2017.10.009	journal	December 2017
Polder maps: improving OMIT maps by excluding bulk solvent Liebschner, Dorothee; Afonine, Pavel V.; Moriarty, Nigel W. Acta Crystallographica Section D Structural Biology, Vol. 73, Issue 2, p. 148-157 https://doi.org/10.1107/S2059798316018210	journal	February 2017

Similar Records

Structural basis for the stereospecific inhibition of the dual proline/hydroxyproline catabolic enzy

Journal Article · 2021 · Protein Sci. · OSTI ID:1812932

Bogner, Alexandra N.; Stiers, Kyle M.; McKay, Cole M.; +2 more

Structural Basis for the Substrate Inhibition of Proline Utilization A by Proline

Journal Article · 2017 · Molecules · OSTI ID:1628485

Korasick, David; Pemberton, Travis; Arentson, Benjamin; +2 more

Understanding the structural basis of species selective, stereospecific inhibition for Cryptosporidium and human thymidylate synthase

Journal Article · 2019 · FEBS Letters · OSTI ID:1557325

Czyzyk, Daniel J.; Valhondo, Margarita; Jorgensen, William L.; +1 more

Structural basis for the stereospecific inhibition of the dual proline/hydroxyproline catabolic enzy

Citation Formats

References (36)

Similar Records

Related Subjects