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A chemical genetics approach to examine the functions of AAA proteins

Journal Article · · Nature Structural & Molecular Biology

Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Organization:
~OTHER
DOE Contract Number:
SC0012704
OSTI ID:
1809000
Report Number(s):
BNL-221895-2021-JACI
Journal Information:
Nature Structural & Molecular Biology, Vol. 28, Issue 4
Country of Publication:
United States
Language:
English

References (50)

The molecular principles governing the activity and functional diversity of AAA+ proteins journal November 2019
AAA+ proteins journal March 2020
Stairway to translocation: AAA+ motor structures reveal the mechanisms of ATP‐dependent substrate translocation journal October 2019
Structure and function of the AAA+ nucleotide binding pocket journal January 2012
Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes journal October 2018
Microtubule-severing enzymes journal February 2010
Mechanisms for initiating cellular DNA replication journal February 2017
CB-6644 Is a Selective Inhibitor of the RUVBL1/2 Complex with Anticancer Activity journal January 2019
Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis journal November 2015
Magic bullets for protein kinases journal April 2001
The Bump-and-Hole Tactic: Expanding the Scope of Chemical Genetics journal October 2018
Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083) journal December 2015
Designing a chemical inhibitor for the AAA protein spastin using active site mutations journal February 2019
Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins journal September 2019
Chemical strategies to overcome resistance against targeted anticancer therapeutics journal July 2020
Development of p97 AAA ATPase inhibitors journal September 2011
Designing Allele-Specific Inhibitors of Spastin, a Microtubule-Severing AAA Protein journal March 2019
Structural Basis of p97 Inhibition by the Site-Selective Anticancer Compound CB-5083 journal December 2018
The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability journal September 2007
Covalent inhibitors: an opportunity for rational target selectivity journal August 2017
Chemical genetic strategy for targeting protein kinases based on covalent complementarity journal August 2011
Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death journal July 2013
Purine-Type Compounds Induce Microtubule Fragmentation and Lung Cancer Cell Death through Interaction with Katanin journal August 2016
Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing journal May 2016
Regulation of microtubule minus-end dynamics by CAMSAPs and Patronin journal March 2014
Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex journal March 2018
Microtubule Minus-End Stabilization by Polymerization-Driven CAMSAP Deposition journal February 2014
Antagonism between BRCA2 and FIGL1 regulates homologous recombination journal April 2019
A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases journal January 2018
Structural and mechanistic studies of VPS4 proteins journal September 2005
Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1 journal February 2006
Structural Role of the Vps4-Vta1 Interface in ESCRT-III Recycling journal August 2010
Prolonged and tunable residence time using reversible covalent kinase inhibitors journal May 2015
CRISPR-Cas guides the future of genetic engineering journal August 2018
Katanin-like 2 (KATNAL2) functions in multiple aspects of haploid male germ cell development in the mouse journal November 2017
Patterns and rates of exonic de novo mutations in autism spectrum disorders journal April 2012
A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases journal May 2005
FIGNL1 is overexpressed in small cell lung cancer patients and enhances NCI-H446 cell resistance to cisplatin and etoposide journal March 2017
Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening journal July 2017
Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells journal July 2020
Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit journal May 2017
Detection of Mycoplasma Contaminations book October 2012
Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II journal January 2019
XDS journal January 2010
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Phaser crystallographic software journal July 2007
Features and development of Coot journal March 2010
Towards automated crystallographic structure refinement with phenix.refine journal March 2012
electronic Ligand Builder and Optimization Workbench ( eLBOW ): a tool for ligand coordinate and restraint generation journal September 2009
MolProbity : all-atom structure validation for macromolecular crystallography journal December 2009

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