Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule

Wigle, T; Ren, Y.; Molina, J.; Blackwell, D.; Schenkel, L.; Swinger, K.; Kuplast‐Barr, K.; Majer, C.; Church, W.; Lu, A.; Mo, J.; Abo, R.; Cheung, A.; Dorsey, B.; Niepel, M.; Perl, N.; Vasbinder, M.; Keilhack, H.; Kuntz, K.

doi:10.1002/cbic.202100047

Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule

Journal Article · 01 January 2022 · ChemBioChem: a European journal of chemical biology

DOI:https://doi.org/10.1002/cbic.202100047· OSTI ID:1808994

Wigle, T; Ren, Y.; Molina, J.; Blackwell, D.; Schenkel, L.; Swinger, K.; Kuplast‐Barr, K.; Majer, C.; Church, W.; Lu, A.; Mo, J.; Abo, R.; Cheung, A.; Dorsey, B.; Niepel, M.; Perl, N.; Vasbinder, M.; Keilhack, H.; Kuntz, K.

Research Organization:: Brookhaven National Lab. (BNL), Upton, NY (United States)

Sponsoring Organization:: ~OTHER

DOE Contract Number:: SC0012704

OSTI ID:: 1808994

Report Number(s):: BNL-221889-2021-JACI

Journal Information:: ChemBioChem: a European journal of chemical biology, Vol. 22, Issue 12

Country of Publication:: United States

Language:: English

References (22)

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PARP-14 Functions as a Transcriptional Switch for Stat6-dependent Gene Activation Mehrotra, Purvi; Riley, Jonathan P.; Patel, Ravi Journal of Biological Chemistry, Vol. 286, Issue 3 https://doi.org/10.1074/jbc.M110.157768	journal	January 2011
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Small Molecule Microarray Based Discovery of PARP14 Inhibitors Peng, Bo; Thorsell, Ann‐Gerd; Karlberg, Tobias Angewandte Chemie, Vol. 129, Issue 1 https://doi.org/10.1002/ange.201609655	journal	December 2016
Design and synthesis of potent inhibitors of the mono(ADP-ribosyl)transferase, PARP14 Upton, Kristen; Meyers, Matthew; Thorsell, Ann-Gerd Bioorganic & Medicinal Chemistry Letters, Vol. 27, Issue 13 https://doi.org/10.1016/j.bmcl.2017.04.089	journal	July 2017
Identification of PARP14 inhibitors using novel methods for detecting auto-ribosylation Yoneyama-Hirozane, Mariko; Matsumoto, Shin-ichi; Toyoda, Yukio Biochemical and Biophysical Research Communications, Vol. 486, Issue 3 https://doi.org/10.1016/j.bbrc.2017.03.052	journal	May 2017
Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14 Holechek, Jacob; Lease, Robert; Thorsell, Ann-Gerd Bioorganic & Medicinal Chemistry Letters, Vol. 28, Issue 11 https://doi.org/10.1016/j.bmcl.2018.04.056	journal	June 2018
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Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14 Schuller, Marion; Riedel, Kerstin; Gibbs-Seymour, Ian ACS Chemical Biology, Vol. 12, Issue 11 https://doi.org/10.1021/acschembio.7b00445	journal	October 2017
Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2 Moustakim, Moses; Riedel, Kerstin; Schuller, Marion Bioorganic & Medicinal Chemistry, Vol. 26, Issue 11 https://doi.org/10.1016/j.bmc.2018.03.020	journal	July 2018
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