Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation

Airola, M; Shanbhogue, P.; Shamseddine, A.; Guja, K.; Senkal, C.; Maini, R.; Bartke, N.; Wu, B.; Obeid, L.; Garcia-Diaz, M.; Hannun, Y.

doi:10.1073/pnas.1705134114

Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation

Journal Article · 01 January 2022 · Proceedings of the National Academy of Sciences of the United States of America

DOI:https://doi.org/10.1073/pnas.1705134114· OSTI ID:1808970

Airola, M; Shanbhogue, P.; Shamseddine, A.; Guja, K.; Senkal, C.; Maini, R.; Bartke, N.; Wu, B.; Obeid, L.; Garcia-Diaz, M.; Hannun, Y.

Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: ~OTHER

DOE Contract Number:: SC0012704

OSTI ID:: 1808970

Report Number(s):: BNL-221865-2021-JACI

Journal Information:: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Issue 28

Country of Publication:: United States

Language:: English

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