Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Structural basis of inhibition of a transporter from Staphylococcus aureus, NorC, through a single-d

Journal Article · · Commun. Biol.
; ; ; ; ; ;

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; FOREIGN
OSTI ID:
1808137
Journal Information:
Commun. Biol., Vol. 4
Country of Publication:
United States
Language:
ENGLISH

References (56)

Efflux-mediated antimicrobial resistance May 2005
Molecular mechanisms of antibiotic resistance December 2014
Multidrug-resistance efflux pumps ? not just for resistance August 2006
Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management May 2015
Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells April 2016
The major facilitator superfamily (MFS) revisited: The major facilitator family revisited May 2012
Bacterial Multidrug Efflux Pumps of the Major Facilitator Superfamily as Targets for Modulation May 2016
Physiological Functions of Bacterial “Multidrug” Efflux Pumps March 2021
Multidrug Efflux Pumps in Staphylococcus aureus: an Update March 2013
NorC, a New Efflux Pump Regulated by MgrA of Staphylococcus aureus March 2006
MgrA Is a Multiple Regulator of Two New Efflux Pumps in Staphylococcus aureus April 2005
The role played by drug efflux pumps in bacterial multidrug resistance February 2017
Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: membrane topology and identification of residues involved in substrate specificity. April 1996
Proton-dependent multidrug efflux systems December 1996
Outward open conformation of a Major Facilitator Superfamily multidrug/H+ antiporter provides insights into switching mechanism October 2018
An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity July 2020
Structure of the Multidrug Transporter EmrD from Escherichia coli May 2006
Bacterial efflux pump inhibitors from natural sources December 2006
Antibiotic Adjuvants: Rescuing Antibiotics from Resistance November 2016
NorB, an Efflux Pump in Staphylococcus aureus Strain MW2, Contributes to Bacterial Fitness in Abscesses November 2008
Role of antibiotic stress in phenotypic switching to persister cells of antibiotic-resistant Staphylococcus aureus February 2020
Mutational analysis and molecular modelling of an amino acid sequence motif conserved in antiporters but not symporters in a transporter superfamily January 1995
Screening of candidate substrates and coupling ions of transporters by thermostability shift assays October 2018
Isolation and structural characterization of a Zn2+-bound single-domain antibody against NorC, a putative multidrug efflux transporter in bacteria January 2020
Shared Molecular Mechanisms of Membrane Transporters June 2016
Energy coupling mechanisms of MFS transporters: Energy Coupling Mechanisms of MFS Transporters September 2015
Alternating access mechanism in the POT family of oligopeptide transporters: Alternating access mechanism in the POT family June 2012
Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT June 2013
Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1 January 2019
Very fast empirical prediction and rationalization of protein pKa values October 2005
Membrane Environment Modulates the p K a Values of Transmembrane Helices March 2015
Structure and Mechanism of a Na+-Independent Amino Acid Transporter July 2009
Dissecting the proton transport pathway in electrogenic Na + /H + antiporters February 2017
Dissection of Protonation Sites for Antibacterial Recognition and Transport in QacA, a Multi-Drug Efflux Transporter May 2019
Nanobodies to Study G Protein–Coupled Receptor Structure and Function January 2017
Crystal Structure of a ligand-bound LacY–Nanobody Complex August 2018
Dissection of Mechanistic Principles of a Secondary Multidrug Efflux Protein September 2012
Therapeutic Nanobodies Targeting Cell Plasma Membrane Transport Proteins: A High-Risk/High-Gain Endeavor January 2021
Generation and Characterization of Specific Monoclonal Antibodies and Nanobodies Directed Against the ATP-Gated Channel P2X4 November 2019
Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation November 2016
Isolation and Characterization of Nanobodies against a Zinc-Transporting P-Type ATPase November 2018
Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport July 2017
Structural basis of nanobody-mediated blocking of BtuF, the cognate substrate-binding protein of the Escherichia coli vitamin B12 transporter BtuCD October 2017
MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms May 2018
XDS January 2010
Scaling and assessment of data quality December 2005
Automatic protein structure solution from weak X-ray data November 2013
Overview of the CCP 4 suite and current developments March 2011
Substructure solution with SHELXD September 2002
Recent developments in classical density modification March 2010
Coot model-building tools for molecular graphics November 2004
Phaser crystallographic software July 2007
REFMAC 5 for the refinement of macromolecular crystal structures March 2011
MolProbity: More and better reference data for improved all-atom structure validation: PROTEIN SCIENCE.ORG November 2017
Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions March 2013
High-throughput stability screening for detergent-solubilized membrane proteins July 2019

Similar Records

Related Subjects