Enhancing isoprenoid synthesis in Yarrowia lipolytica by expressing the isopentenol utilization pathway and modulating intracellular hydrophobicity
Abstract
Not provided.
- Authors:
- Publication Date:
- Research Org.:
- Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
- Sponsoring Org.:
- USDOE Office of Energy Efficiency and Renewable Energy (EERE)
- OSTI Identifier:
- 1799302
- DOE Contract Number:
- EE0007531; SC0008744
- Resource Type:
- Journal Article
- Journal Name:
- Metabolic Engineering
- Additional Journal Information:
- Journal Volume: 61; Journal Issue: C; Journal ID: ISSN 1096-7176
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- Biotechnology & Applied Microbiology
Citation Formats
Luo, Zhengshan, Liu, Nian, Lazar, Zbigniew, Chatzivasileiou, Alkiviadis, Ward, Valerie, Chen, Jian, Zhou, Jingwen, and Stephanopoulos, Gregory. Enhancing isoprenoid synthesis in Yarrowia lipolytica by expressing the isopentenol utilization pathway and modulating intracellular hydrophobicity. United States: N. p., 2020.
Web. doi:10.1016/j.ymben.2020.07.010.
Luo, Zhengshan, Liu, Nian, Lazar, Zbigniew, Chatzivasileiou, Alkiviadis, Ward, Valerie, Chen, Jian, Zhou, Jingwen, & Stephanopoulos, Gregory. Enhancing isoprenoid synthesis in Yarrowia lipolytica by expressing the isopentenol utilization pathway and modulating intracellular hydrophobicity. United States. https://doi.org/10.1016/j.ymben.2020.07.010
Luo, Zhengshan, Liu, Nian, Lazar, Zbigniew, Chatzivasileiou, Alkiviadis, Ward, Valerie, Chen, Jian, Zhou, Jingwen, and Stephanopoulos, Gregory. 2020.
"Enhancing isoprenoid synthesis in Yarrowia lipolytica by expressing the isopentenol utilization pathway and modulating intracellular hydrophobicity". United States. https://doi.org/10.1016/j.ymben.2020.07.010.
@article{osti_1799302,
title = {Enhancing isoprenoid synthesis in Yarrowia lipolytica by expressing the isopentenol utilization pathway and modulating intracellular hydrophobicity},
author = {Luo, Zhengshan and Liu, Nian and Lazar, Zbigniew and Chatzivasileiou, Alkiviadis and Ward, Valerie and Chen, Jian and Zhou, Jingwen and Stephanopoulos, Gregory},
abstractNote = {Not provided.},
doi = {10.1016/j.ymben.2020.07.010},
url = {https://www.osti.gov/biblio/1799302},
journal = {Metabolic Engineering},
issn = {1096-7176},
number = C,
volume = 61,
place = {United States},
year = {Tue Sep 01 00:00:00 EDT 2020},
month = {Tue Sep 01 00:00:00 EDT 2020}
}
Other availability
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli
journal, September 2010
- Ajikumar, P. K.; Xiao, W.-H.; Tyo, K. E. J.
- Science, Vol. 330, Issue 6000, p. 70-74
Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli
journal, May 2005
- Alper, Hal; Jin, Yong-Su; Moxley, J. F.
- Metabolic Engineering, Vol. 7, Issue 3
Production of isoprenoid pharmaceuticals by engineered microbes
journal, November 2006
- Chang, Michelle C. Y.; Keasling, Jay D.
- Nature Chemical Biology, Vol. 2, Issue 12
Current development in isoprenoid precursor biosynthesis and regulation
journal, August 2013
- Chang, Wei-chen; Song, Heng; Liu, Hung-wen
- Current Opinion in Chemical Biology, Vol. 17, Issue 4
Two-step pathway for isoprenoid synthesis
journal, December 2018
- Chatzivasileiou, Alkiviadis Orfefs; Ward, Valerie; Edgar, Steven McBride
- Proceedings of the National Academy of Sciences, Vol. 116, Issue 2
Synthetic and systems biology for microbial production of commodity chemicals
journal, April 2016
- Chubukov, Victor; Mukhopadhyay, Aindrila; Petzold, Christopher J.
- npj Systems Biology and Applications, Vol. 2, Issue 1
The isoprenoid alcohol pathway, a synthetic route for isoprenoid biosynthesis
journal, June 2019
- Clomburg, James M.; Qian, Shuai; Tan, Zaigao
- Proceedings of the National Academy of Sciences, Vol. 116, Issue 26
Metabolic engineering of Saccharomyces cerevisiae for production of butanol isomers
journal, June 2015
- Generoso, Wesley Cardoso; Schadeweg, Virginia; Oreb, Mislav
- Current Opinion in Biotechnology, Vol. 33
Lycopene: Progress in microbial production
journal, October 2016
- Hernández-Almanza, Ayerim; Montañez, Julio; Martínez, Guillermo
- Trends in Food Science & Technology, Vol. 56
Introduction: Natural Product Synthesis
journal, August 2017
- Herzon, Seth B.; Vanderwal, Christopher D.
- Chemical Reviews, Vol. 117, Issue 18
Paclitaxel: biosynthesis, production and future prospects
journal, May 2014
- Howat, Susan; Park, Bora; Oh, Il Suk
- New Biotechnology, Vol. 31, Issue 3
Recent advances in bioengineering of the oleaginous yeast Yarrowia lipolytica
journal, January 2016
- Shabbir Hussain, Murtaza; M. Rodriguez, Gabriel; Gao, Difeng
- AIMS Bioengineering, Vol. 3, Issue 4
Extraction and Analysis of Terpenes/Terpenoids
journal, March 2016
- Jiang, Zuodong; Kempinski, Chase; Chappell, Joe
- Current Protocols in Plant Biology, Vol. 1, Issue 2
The isoprenoid pathway and transcriptional response to its inhibitors in the yeast Saccharomyces cerevisiae
journal, February 2010
- Kuranda, Klaudia; François, Jean; Palamarczyk, Grażyna
- FEMS Yeast Research, Vol. 10, Issue 1
Constructing Tailored Isoprenoid Products by Structure-Guided Modification of Geranylgeranyl Reductase
journal, July 2014
- Kung, Yan; McAndrew, Ryan P.; Xie, Xinkai
- Structure, Vol. 22, Issue 7
Yarrowia lipolytica as a biotechnological chassis to produce usual and unusual fatty acids
journal, January 2016
- Ledesma-Amaro, Rodrigo; Nicaud, Jean-Marc
- Progress in Lipid Research, Vol. 61
Biotechnological applications of Yarrowia lipolytica: Past, present and future
journal, December 2015
- Liu, Hu-Hu; Ji, Xiao-Jun; Huang, He
- Biotechnology Advances, Vol. 33, Issue 8
13C Metabolic Flux Analysis of acetate conversion to lipids by Yarrowia lipolytica
journal, November 2016
- Liu, Nian; Qiao, Kangjian; Stephanopoulos, Gregory
- Metabolic Engineering, Vol. 38
Isoprenoid biosynthesis in eukaryotic phototrophs: A spotlight on algae
journal, April 2012
- Lohr, Martin; Schwender, Jörg; Polle, Jürgen E. W.
- Plant Science, Vol. 185-186
An Artificial Pathway for Isoprenoid Biosynthesis Decoupled from Native Hemiterpene Metabolism
journal, January 2019
- Lund, Sean; Hall, Rachael; Williams, Gavin J.
- ACS Synthetic Biology, Vol. 8, Issue 2
Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene
journal, March 2019
- Ma, Tian; Shi, Bin; Ye, Ziling
- Metabolic Engineering, Vol. 52
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
journal, June 2003
- Martin, Vincent J. J.; Pitera, Douglas J.; Withers, Sydnor T.
- Nature Biotechnology, Vol. 21, Issue 7
Production of Lycopene in the Non-Carotenoid-Producing Yeast Yarrowia lipolytica
journal, December 2013
- Matthäus, Falk; Ketelhot, Markus; Gatter, Michael
- Applied and Environmental Microbiology, Vol. 80, Issue 5
Occurrence, biosynthesis and function of isoprenoid quinones
journal, September 2010
- Nowicka, Beatrycze; Kruk, Jerzy
- Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1797, Issue 9
Isoprenoid lipid chains increase membrane resistance to pore formation
journal, October 2014
- Panov, P. V.; Akimov, S. A.; Batishchev, O. V.
- Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, Vol. 8, Issue 4
Lipid production in Yarrowia lipolytica is maximized by engineering cytosolic redox metabolism
journal, January 2017
- Qiao, Kangjian; Wasylenko, Thomas M.; Zhou, Kang
- Nature Biotechnology, Vol. 35, Issue 2
Regulation of lipid accumulation in oleaginous micro-organisms
journal, November 2002
- Ratledge, C.
- Biochemical Society Transactions, Vol. 30, Issue 6, p. 1047-1050
Exploring natural biodiversity to expand access to microbial terpene synthesis
journal, February 2019
- Rico, Juan; Duquesne, Katia; Petit, Jean-Louis
- Microbial Cell Factories, Vol. 18, Issue 1
Standardized Markerless Gene Integration for Pathway Engineering in Yarrowia lipolytica
journal, November 2016
- Schwartz, Cory; Shabbir-Hussain, Murtaza; Frogue, Keith
- ACS Synthetic Biology, Vol. 6, Issue 3
Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production
journal, January 2013
- Tai, Mitchell; Stephanopoulos, Gregory
- Metabolic Engineering, Vol. 15, p. 1-9
Recent advances in synthetic biology for engineering isoprenoid production in yeast
journal, October 2017
- Vickers, Claudia E.; Williams, Thomas C.; Peng, Bingyin
- Current Opinion in Chemical Biology, Vol. 40
Metabolic engineering of Escherichia coli for the production of isoprenoids
journal, March 2018
- Ward, Valerie C. A.; Chatzivasileiou, Alkiviadis O.; Stephanopoulos, Gregory
- FEMS Microbiology Letters, Vol. 365, Issue 10
Cell free biosynthesis of isoprenoids from isopentenol
journal, September 2019
- Ward, Valerie C. A.; Chatzivasileiou, Alkiviadis Orfefs; Stephanopoulos, Gregory
- Biotechnology and Bioengineering, Vol. 116, Issue 12
The oxidative pentose phosphate pathway is the primary source of NADPH for lipid overproduction from glucose in Yarrowia lipolytica
journal, July 2015
- Wasylenko, Thomas M.; Ahn, Woo Suk; Stephanopoulos, Gregory
- Metabolic Engineering, Vol. 30
Improved squalene production through increasing lipid contents in Saccharomyces cerevisiae
journal, April 2018
- Wei, Liu-Jing; Kwak, Suryang; Liu, Jing-Jing
- Biotechnology and Bioengineering, Vol. 115, Issue 7
Engineering Yarrowia lipolytica as a platform for synthesis of drop-in transportation fuels and oleochemicals
journal, September 2016
- Xu, Peng; Qiao, Kangjian; Ahn, Woo Suk
- Proceedings of the National Academy of Sciences, Vol. 113, Issue 39