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Structural and Functional Analysis of mRNA Export Regulation by the Nuclear Pore Complex

Journal Article · · Nature Communications
Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Organization:
~OTHER
DOE Contract Number:
SC0012704;
OSTI ID:
1786317
Report Number(s):
BNL-221622-2021-JACI
Journal Information:
Nature Communications, Journal Name: Nature Communications Journal Issue: 2319 Vol. 9; ISSN 2041-1723
Country of Publication:
United States
Language:
English

References (67)

UCSF Chimera?A visualization system for exploratory research and analysis journal January 2004
A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes journal August 2004
An improved method for whole protein extraction from yeast Saccharomyces cerevisiae: Yeast protein extraction by LiAc/NaOH journal October 2011
Assessing the omnipotence of inositol hexakisphosphate journal March 2001
Ulp1-SUMO Crystal Structure and Genetic Analysis Reveal Conserved Interactions and a Regulatory Element Essential for Cell Growth in Yeast journal May 2000
Crystal Structure of a Tetradecameric Assembly of the Association Domain of Ca2+/Calmodulin-Dependent Kinase II journal May 2003
Gle1 Functions during mRNA Export in an Oligomeric Complex that Is Altered in Human Disease journal October 2013
Insights into mRNA export-linked molecular mechanisms of human disease through a Gle1 structure–function analysis journal January 2014
The DEAD-Box Protein Dbp5p Is Required to Dissociate Mex67p from Exported mRNPs at the Nuclear Rim journal November 2005
Mutant Huntingtin Disrupts the Nuclear Pore Complex journal April 2017
Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport journal April 2017
Aberrant distributions of nuclear pore complex proteins in ALS mice and ALS patients journal May 2017
Nuclear export of mRNA journal November 2010
In vivo imaging of labelled endogenous β-actin mRNA during nucleocytoplasmic transport journal September 2010
A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export journal March 2011
The C9orf72 repeat expansion disrupts nucleocytoplasmic transport journal August 2015
GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport journal August 2015
In situ structural analysis of the human nuclear pore complex journal September 2015
Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export journal June 2006
Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export journal June 2006
High-resolution three-dimensional mapping of mRNA export through the nuclear pore journal September 2013
Automatic protein structure solution from weak X-ray data journal November 2013
Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease journal January 2008
Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS journal August 2015
The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability journal September 2007
The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner journal February 2009
Linker Nups connect the nuclear pore complex inner ring with the outer ring and transport channel journal September 2015
Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis journal May 2006
Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN journal January 2007
Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19 journal February 2009
Structure of the C-terminus of the mRNA export factor Dbp5 reveals the interaction surface for the ATPase activator Gle1 journal September 2009
Toxic PR n poly-dipeptides encoded by the C9orf72 repeat expansion block nuclear import and export journal January 2017
Electrostatics of nanosystems: Application to microtubules and the ribosome journal August 2001
The DE X D/H-box RNA Helicase DDX19 Is Regulated by an α-Helical Switch journal February 2009
Control of mRNA Export and Translation Termination by Inositol Hexakisphosphate Requires Specific Interaction with Gle1 journal April 2010
Gle1 Is a Multifunctional DEAD-box Protein Regulator That Modulates Ded1 in Translation Initiation journal September 2011
The mRNA Export Factor Human Gle1 Interacts with the Nuclear Pore Complex Protein Nup155 journal November 2003
An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export journal March 2003
Interaction between the Shuttling mRNA Export Factor Gle1 and the Nucleoporin hCG1: A Conserved Mechanism in the Export of Hsp70 mRNA journal September 2005
Cytoplasmic hGle1A regulates stress granules by modulation of translation journal April 2015
Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p journal August 1999
The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr255p journal October 1999
Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells journal October 1999
The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human journal May 1999
Deleterious mutations in the essential mRNA metabolism factor, hGle1, in amyotrophic lateral sclerosis journal October 2014
MUSCLE: multiple sequence alignment with high accuracy and high throughput journal March 2004
Scalable web services for the PSIPRED Protein Analysis Workbench journal June 2013
RNA helicase DDX19 stabilizes ribosomal elongation and termination complexes journal December 2016
ALSCRIPT: a tool to format multiple sequence alignments journal January 1993
Yeast heat shock mRNAs are exported through a distinct pathway defined by Rip1p journal November 1997
The Dbp5 cycle at the nuclear pore complex during mRNA export II: nucleotide cycling and mRNP remodeling by Dbp5 are controlled by Nup159 and Gle1 journal May 2011
Phaser crystallographic software journal July 2007
MolProbity : all-atom structure validation for macromolecular crystallography journal December 2009
XDS journal January 2010
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
How good are my data and what is the resolution? journal June 2013
A new MR-SAD algorithm for the automatic building of protein models from low-resolution X-ray data and a poor starting model journal January 2018
Nup42 and IP 6 coordinate Gle1 stimulation of Dbp5/DDX19B for mRNA export in yeast and human cells : ADAMS journal October 2017
Architecture of the fungal nuclear pore inner ring complex journal August 2015
Molecular architecture of the inner ring scaffold of the human nuclear pore complex journal April 2016
Architecture of the symmetric core of the nuclear pore journal April 2016
The Nuclear Pore Complex and the DEAD Box Protein Rat8p/Dbp5p Have Nonessential Features Which Appear To Facilitate mRNA Export following Heat Shock journal May 2004
The Structure of the Nuclear Pore Complex journal July 2011
Nuclear Export of Pre-Ribosomal Subunits Requires Dbp5, but Not as an RNA-Helicase as for mRNA Export journal February 2016
An ATR ‐dependent function for the Ddx19 RNA helicase in nuclear R‐loop metabolism journal March 2017
Nucleoporin FG Domains Facilitate mRNP Remodeling at the Cytoplasmic Face of the Nuclear Pore Complex journal June 2014
Dbp5, Gle1-IP 6 and Nup159 : A working model for mRNP export journal November 2011

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