VSV-Displayed HIV-1 Envelope Identifies Broadly Neutralizing Antibodies Class-Switched to IgG and IgA

Jia, M; Liberatore, R.; Guo, Y.; Chan, K.; Pan, R.; Lu, H.; Waltari, E.; Mittler, E.; Chandran, K.; Finzi, A.; Kaufmann, D.; Seaman, M.; Ho, D.; Shapiro, L.; Sheng, Z.; Kong, X.; Bieniasz, P.; Wu, X.

doi:10.1016/j.chom.2020.03.024

VSV-Displayed HIV-1 Envelope Identifies Broadly Neutralizing Antibodies Class-Switched to IgG and IgA

Journal Article · 01 January 2022 · Cell Host & Microbe

DOI:https://doi.org/10.1016/j.chom.2020.03.024· OSTI ID:1783953

Jia, M; Liberatore, R.; Guo, Y.; Chan, K.; Pan, R.; Lu, H.; Waltari, E.; Mittler, E.; Chandran, K.; Finzi, A.; Kaufmann, D.; Seaman, M.; Ho, D.; Shapiro, L.; Sheng, Z.; Kong, X.; Bieniasz, P.; Wu, X.

Research Organization:: Brookhaven National Lab. (BNL), Upton, NY (United States)

Sponsoring Organization:: ~OTHER

DOE Contract Number:: SC0012704

OSTI ID:: 1783953

Report Number(s):: BNL-221484-2021-JACI

Journal Information:: Cell Host & Microbe, Vol. 27, Issue 6

Country of Publication:: United States

Language:: English

References (90)

PHENIX: a comprehensive Python-based system for macromolecular structure solution Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221 https://doi.org/10.1107/S0907444909052925	journal	January 2010
Cross-neutralizing activity of human anti-V3 monoclonal antibodies derived from non-B clade HIV-1 infected individuals Andrabi, Raiees; Williams, Constance; Wang, Xiao-Hong Virology, Vol. 439, Issue 2 https://doi.org/10.1016/j.virol.2012.12.010	journal	May 2013
The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling Arnold, Konstantin; Bordoli, Lorenza; Kopp, Jürgen Bioinformatics, Vol. 22, Issue 2 https://doi.org/10.1093/bioinformatics/bti770	journal	November 2005
Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals Baxter, Amy E.; Niessl, Julia; Fromentin, Rémi Cell Host & Microbe, Vol. 20, Issue 3 https://doi.org/10.1016/j.chom.2016.07.015	journal	September 2016
Structural Basis of the Cross-Reactivity of Genetically Related Human Anti-HIV-1 mAbs: Implications for Design of V3-Based Immunogens Burke, Valicia; Williams, Constance; Sukumaran, Madhav Structure, Vol. 17, Issue 11 https://doi.org/10.1016/j.str.2009.09.012	journal	November 2009
Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop Cale, Evan M.; Gorman, Jason; Radakovich, Nathan A. Immunity, Vol. 46, Issue 5 https://doi.org/10.1016/j.immuni.2017.04.011	journal	May 2017
Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117 Caskey, Marina; Klein, Florian; Lorenzi, Julio C. C. Nature, Vol. 522, Issue 7557 https://doi.org/10.1038/nature14411	journal	April 2015
Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic Caskey, Marina; Klein, Florian; Nussenzweig, Michel C. Nature Medicine, Vol. 25, Issue 4 https://doi.org/10.1038/s41591-019-0412-8	journal	April 2019
The regulation of IgA class switching Cerutti, Andrea Nature Reviews Immunology, Vol. 8, Issue 6 https://doi.org/10.1038/nri2322	journal	June 2008
Structural Comparison of Human Anti-HIV-1 gp120 V3 Monoclonal Antibodies of the Same Gene Usage Induced by Vaccination and Chronic Infection Chan, Kun-Wei; Pan, Ruimin; Costa, Matthew Journal of Virology, Vol. 92, Issue 18 https://doi.org/10.1128/JVI.00641-18	journal	September 2018
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair Chaudhuri, Jayanta; Alt, Frederick W. Nature Reviews Immunology, Vol. 4, Issue 7 https://doi.org/10.1038/nri1395	journal	July 2004
MolProbity : all-atom structure validation for macromolecular crystallography Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1 https://doi.org/10.1107/S0907444909042073	journal	December 2009
Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition Chuang, Gwo-Yu; Zhou, Jing; Acharya, Priyamvada Structure, Vol. 27, Issue 1 https://doi.org/10.1016/j.str.2018.10.007	journal	January 2019
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies Doria-Rose, Nicole A.; Schramm, Chaim A.; Gorman, Jason Nature, Vol. 509, Issue 7498 https://doi.org/10.1038/nature13036	journal	March 2014
IgA Targeting Human Immunodeficiency Virus-1 Envelope gp41 Triggers Antibody-Dependent Cellular Cytotoxicity Cross-Clade and Cooperates with gp41-Specific IgG to Increase Cell Lysis Duchemin, Maxence; Khamassi, Marwa; Xu, Lin Frontiers in Immunology, Vol. 9 https://doi.org/10.3389/fimmu.2018.00244	journal	March 2018
Error filtering, pair assembly and error correction for next-generation sequencing reads Edgar, Robert C.; Flyvbjerg, Henrik Bioinformatics, Vol. 31, Issue 21 https://doi.org/10.1093/bioinformatics/btv401	journal	July 2015
Coot model-building tools for molecular graphics Emsley, Paul; Cowtan, Kevin Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132 https://doi.org/10.1107/S0907444904019158	journal	November 2004
Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers Falkowska, Emilia; Le, Khoa M.; Ramos, Alejandra Immunity, Vol. 40, Issue 5 https://doi.org/10.1016/j.immuni.2014.04.009	journal	May 2014
Escherichia coli Expression, Purification, and Biological Activity of a Truncated Soluble CD4 Garlick, Robert L.; Kirschner, Richard J.; Eckenrode, Frances M. AIDS Research and Human Retroviruses, Vol. 6, Issue 4 https://doi.org/10.1089/aid.1990.6.465	journal	April 1990
Anti-HIV IgM protects against mucosal SHIV transmission Gong, Siqi; Tomusange, Khamis; Kulkarni, Viraj AIDS, Vol. 32, Issue 11 https://doi.org/10.1097/QAD.0000000000001857	journal	January 2018
Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design Gorman, Jason; Soto, Cinque; Yang, Max M. Nature Structural & Molecular Biology, Vol. 23, Issue 1 https://doi.org/10.1038/nsmb.3144	journal	December 2015
Neutralization of diverse human immunodeficiency virus type 1 variants by an anti-V3 human monoclonal antibody. Gorny, M. K.; Conley, A. J.; Karwowska, S. Journal of Virology, Vol. 66, Issue 12 https://doi.org/10.1128/JVI.66.12.7538-7542.1992	journal	January 1992
Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial Haynes, Barton F.; Gilbert, Peter B.; McElrath, M. Juliana New England Journal of Medicine, Vol. 366, Issue 14 https://doi.org/10.1056/NEJMoa1113425	journal	April 2012
Lineage tracing of human B cells reveals the in vivo landscape of human antibody class switching Horns, Felix; Vollmers, Christopher; Croote, Derek eLife, Vol. 5 https://doi.org/10.7554/eLife.16578	journal	August 2016
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody Huang, Jinghe; Ofek, Gilad; Laub, Leo Nature, Vol. 491, Issue 7424 https://doi.org/10.1038/nature11544	journal	September 2012
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface Huang, Jinghe; Kang, Byong H.; Pancera, Marie Nature, Vol. 515, Issue 7525 https://doi.org/10.1038/nature13601	journal	September 2014
Development of Broadly Neutralizing Antibodies and Their Mapping by Monomeric gp120 in Human Immunodeficiency Virus Type 1-Infected Humans and Simian-Human Immunodeficiency Virus SHIV _SF162P3N -Infected Macaques Jia, Manxue; Lu, Hong; Markowitz, Martin Journal of Virology, Vol. 90, Issue 8 https://doi.org/10.1128/JVI.02898-15	journal	February 2016
XDS Kabsch, Wolfgang Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2 https://doi.org/10.1107/S0907444909047337	journal	January 2010
MX2 is an interferon-induced inhibitor of HIV-1 infection Kane, Melissa; Yadav, Shalini S.; Bitzegeio, Julia Nature, Vol. 502, Issue 7472 https://doi.org/10.1038/nature12653	journal	October 2013
Few and Far Between: How HIV May Be Evading Antibody Avidity Klein, Joshua S.; Bjorkman, Pamela J. PLoS Pathogens, Vol. 6, Issue 5 https://doi.org/10.1371/journal.ppat.1000908	journal	May 2010
Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion Kleinfelter, Lara M.; Jangra, Rohit K.; Jae, Lucas T. mBio, Vol. 6, Issue 4 https://doi.org/10.1128/mBio.00801-15	journal	September 2015
Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody Kong, R.; Xu, K.; Zhou, T. Science, Vol. 352, Issue 6287 https://doi.org/10.1126/science.aae0474	journal	May 2016
Mucosal IgA Responses: Damaged in Established HIV Infection—Yet, Effective Weapon against HIV Transmission Kulkarni, Viraj; Ruprecht, Ruth M. Frontiers in Immunology, Vol. 8 https://doi.org/10.3389/fimmu.2017.01581	journal	November 2017
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody Kwong, Peter D.; Wyatt, Richard; Robinson, James Nature, Vol. 393, Issue 6686 https://doi.org/10.1038/31405	journal	June 1998
IMGT®, the international ImMunoGeneTics information system® 25 years on Lefranc, Marie-Paule; Giudicelli, Véronique; Duroux, Patrice Nucleic Acids Research, Vol. 43, Issue D1 https://doi.org/10.1093/nar/gku1056	journal	November 2014
High Multiplicity Infection by HIV-1 in Men Who Have Sex with Men Li, Hui; Bar, Katharine J.; Wang, Shuyi PLoS Pathogens, Vol. 6, Issue 5 https://doi.org/10.1371/journal.ppat.1000890	journal	May 2010
A broad range of mutations in HIV-1 neutralizing human monoclonal antibodies specific for V2, V3, and the CD4 binding site Li, Liuzhe; Wang, Xiao-Hong; Williams, Constance Molecular Immunology, Vol. 66, Issue 2 https://doi.org/10.1016/j.molimm.2015.04.011	journal	August 2015
Rhabdo-immunodeficiency virus, a murine model of acute HIV-1 infection Liberatore, Rachel A.; Mastrocola, Emily J.; Cassella, Elena eLife, Vol. 8 https://doi.org/10.7554/eLife.49875	journal	October 2019
IgA subclass switch recombination in human mucosal and systemic immune compartments Lin, M.; Du, L.; Brandtzaeg, P. Mucosal Immunology, Vol. 7, Issue 3 https://doi.org/10.1038/mi.2013.68	journal	September 2013
The Multifaceted Nature of Immunoglobulin A and Its Complex Role in HIV Lopez, Ester; Shattock, Robin J.; Kent, Stephen J. AIDS Research and Human Retroviruses, Vol. 34, Issue 9 https://doi.org/10.1089/aid.2018.0099	journal	September 2018
Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET Lu, Maolin; Ma, Xiaochu; Castillo-Menendez, Luis R. Nature, Vol. 568, Issue 7752 https://doi.org/10.1038/s41586-019-1101-y	journal	April 2019
Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection Lynch, Rebecca M.; Boritz, Eli; Coates, Emily E. Science Translational Medicine, Vol. 7, Issue 319 https://doi.org/10.1126/scitranslmed.aad5752	journal	December 2015
The immune geography of IgA induction and function Macpherson, A. J.; McCoy, K. D.; Johansen, F-E Mucosal Immunology, Vol. 1, Issue 1 https://doi.org/10.1038/mi.2007.6	journal	December 2007
Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals Magri, Giuliana; Comerma, Laura; Pybus, Marc Immunity, Vol. 47, Issue 1 https://doi.org/10.1016/j.immuni.2017.06.013	journal	July 2017
SuperPose: a simple server for sophisticated structural superposition Maiti, R.; Van Domselaar, G. H.; Zhang, H. Nucleic Acids Research, Vol. 32, Issue Web Server https://doi.org/10.1093/nar/gkh477	journal	July 2004
Automated electron microscope tomography using robust prediction of specimen movements Mastronarde, David N. Journal of Structural Biology, Vol. 152, Issue 1 https://doi.org/10.1016/j.jsb.2005.07.007	journal	October 2005
Phaser crystallographic software McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D. Journal of Applied Crystallography, Vol. 40, Issue 4 https://doi.org/10.1107/S0021889807021206	journal	July 2007
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9 McLellan, Jason S.; Pancera, Marie; Carrico, Chris Nature, Vol. 480, Issue 7377 https://doi.org/10.1038/nature10696	journal	November 2011
Mucosal immunology of the genital and gastrointestinal tracts and HIV-1 infection Mestecky, Jiri; Moldoveanu, Zina; Smith, Phillip D. Journal of Reproductive Immunology, Vol. 83, Issue 1-2 https://doi.org/10.1016/j.jri.2009.07.005	journal	December 2009
The V1V2 Region of HIV-1 gp120 Forms a Five-Stranded Beta Barrel Pan, Ruimin; Gorny, Miroslaw K.; Zolla-Pazner, Susan Journal of Virology, Vol. 89, Issue 15 https://doi.org/10.1128/JVI.00754-15	journal	May 2015
A Meta-analysis of Passive Immunization Studies Shows that Serum-Neutralizing Antibody Titer Associates with Protection against SHIV Challenge Pegu, Amarendra; Borate, Bhavesh; Huang, Yunda Cell Host & Microbe, Vol. 26, Issue 3 https://doi.org/10.1016/j.chom.2019.08.014	journal	September 2019
A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield Pejchal, R.; Doores, K. J.; Walker, L. M. Science, Vol. 334, Issue 6059 https://doi.org/10.1126/science.1213256	journal	October 2011
UCSF Chimera?A visualization system for exploratory research and analysis Pettersen, Eric F.; Goddard, Thomas D.; Huang, Conrad C. Journal of Computational Chemistry, Vol. 25, Issue 13 https://doi.org/10.1002/jcc.20084	journal	January 2004
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination Punjani, Ali; Rubinstein, John L.; Fleet, David J. Nature Methods, Vol. 14, Issue 3 https://doi.org/10.1038/nmeth.4169	journal	February 2017
CTFFIND4: Fast and accurate defocus estimation from electron micrographs Rohou, Alexis; Grigorieff, Nikolaus Journal of Structural Biology, Vol. 192, Issue 2 https://doi.org/10.1016/j.jsb.2015.08.008	journal	November 2015
Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo Rudicell, R. S.; Kwon, Y. D.; Ko, S. -Y. Journal of Virology, Vol. 88, Issue 21 https://doi.org/10.1128/JVI.02213-14	journal	August 2014
Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models Saunders, Kevin O.; Verkoczy, Laurent K.; Jiang, Chuancang Cell Reports, Vol. 21, Issue 13 https://doi.org/10.1016/j.celrep.2017.12.028	journal	December 2017
Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding Scheid, J. F.; Mouquet, H.; Ueberheide, B. Science, Vol. 333, Issue 6049 https://doi.org/10.1126/science.1207227	journal	July 2011
RELION: Implementation of a Bayesian approach to cryo-EM structure determination Scheres, Sjors H. W. Journal of Structural Biology, Vol. 180, Issue 3, p. 519-530 https://doi.org/10.1016/j.jsb.2012.09.006	journal	December 2012
Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope Schoofs, Till; Barnes, Christopher O.; Suh-Toma, Nina Immunity, Vol. 50, Issue 6 https://doi.org/10.1016/j.immuni.2019.04.014	journal	June 2019
SONAR: A High-Throughput Pipeline for Inferring Antibody Ontogenies from Longitudinal Sequencing of B Cell Transcripts Schramm, Chaim A.; Sheng, Zizhang; Zhang, Zhenhai Frontiers in Immunology, Vol. 7 https://doi.org/10.3389/fimmu.2016.00372	journal	September 2016
Standardized assessment of NAb responses elicited in rhesus monkeys immunized with single- or multi-clade HIV-1 envelope immunogens Seaman, Michael S.; LeBlanc, Daniel F.; Grandpre, Lauren E. Virology, Vol. 367, Issue 1 https://doi.org/10.1016/j.virol.2007.05.024	journal	October 2007
Tiered Categorization of a Diverse Panel of HIV-1 Env Pseudoviruses for Assessment of Neutralizing Antibodies Seaman, M. S.; Janes, H.; Hawkins, N. Journal of Virology, Vol. 84, Issue 3 https://doi.org/10.1128/JVI.02108-09	journal	November 2009
Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation Sheng, Zizhang; Schramm, Chaim A.; Kong, Rui Frontiers in Immunology, Vol. 8 https://doi.org/10.3389/fimmu.2017.00537	journal	May 2017
Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega Sievers, Fabian; Wilm, Andreas; Dineen, David Molecular Systems Biology, Vol. 7, Issue 1 https://doi.org/10.1038/msb.2011.75	journal	January 2011
Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway Spence, Jennifer S.; Krause, Tyler B.; Mittler, Eva mBio, Vol. 7, Issue 1 https://doi.org/10.1128/mBio.01857-15	journal	March 2016
MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0 Tamura, Koichiro; Stecher, Glen; Peterson, Daniel Molecular Biology and Evolution, Vol. 30, Issue 12 https://doi.org/10.1093/molbev/mst197	journal	October 2013
Mass and molecular composition of vesicular stomatitis virus: a scanning transmission electron microscopy analysis Thomas, D.; Newcomb, W. W.; Brown, J. C. Journal of Virology, Vol. 54, Issue 2 https://doi.org/10.1128/JVI.54.2.598-607.1985	journal	May 1985
Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning Tiller, Thomas; Meffre, Eric; Yurasov, Sergey Journal of Immunological Methods, Vol. 329, Issue 1-2 https://doi.org/10.1016/j.jim.2007.09.017	journal	January 2008
Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody Tudor, D.; Yu, H.; Maupetit, J. Proceedings of the National Academy of Sciences, Vol. 109, Issue 31 https://doi.org/10.1073/pnas.1200024109	journal	June 2012
The HIV-1 gp120 CD4-Bound Conformation Is Preferentially Targeted by Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies in Sera from HIV-1-Infected Individuals Veillette, Maxime; Coutu, Mathieu; Richard, Jonathan Journal of Virology, Vol. 89, Issue 1 https://doi.org/10.1128/JVI.02868-14	journal	October 2014
Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target Walker, L. M.; Phogat, S. K.; Chan-Hui, P. -Y. Science, Vol. 326, Issue 5950 https://doi.org/10.1126/science.1178746	journal	September 2009
Broad neutralization coverage of HIV by multiple highly potent antibodies Walker, Laura M.; Huber, Michael; Doores, Katie J. Nature, Vol. 477, Issue 7365 https://doi.org/10.1038/nature10373	journal	September 2011
5′ Rapid Amplification of cDNA Ends and Illumina MiSeq Reveals B Cell Receptor Features in Healthy Adults, Adults With Chronic HIV-1 Infection, Cord Blood, and Humanized Mice Waltari, Eric; Jia, Manxue; Jiang, Caroline S. Frontiers in Immunology, Vol. 9 https://doi.org/10.3389/fimmu.2018.00628	journal	March 2018
Partially Open HIV-1 Envelope Structures Exhibit Conformational Changes Relevant for Coreceptor Binding and Fusion Wang, Haoqing; Barnes, Christopher O.; Yang, Zhi Cell Host & Microbe, Vol. 24, Issue 4 https://doi.org/10.1016/j.chom.2018.09.003	journal	October 2018
Potent and broad HIV-neutralizing antibodies in memory B cells and plasma Williams, LaTonya D.; Ofek, Gilad; Schätzle, Sebastian Science Immunology, Vol. 2, Issue 7 https://doi.org/10.1126/sciimmunol.aal2200	journal	January 2017
Characterization of Human Class-Switched Polymeric (Immunoglobulin M [IgM] and IgA) Anti-Human Immunodeficiency Virus Type 1 Antibodies 2F5 and 2G12 Wolbank, S.; Kunert, R.; Stiegler, G. Journal of Virology, Vol. 77, Issue 7 https://doi.org/10.1128/JVI.77.7.4095-4103.2003	journal	April 2003
Tropism-Restricted Neutralization by Secretory IgA from Parotid Saliva of HIV Type 1-Infected Individuals Wu, Xueling; Hall, Stacy; Jackson, Susan AIDS Research and Human Retroviruses, Vol. 19, Issue 4 https://doi.org/10.1089/088922203764969474	journal	April 2003
Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1 Wu, X.; Yang, Z. -Y.; Li, Y. Science, Vol. 329, Issue 5993 https://doi.org/10.1126/science.1187659	journal	July 2010
Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing Wu, X.; Zhou, T.; Zhu, J. Science, Vol. 333, Issue 6049 https://doi.org/10.1126/science.1207532	journal	August 2011
Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection Wu, Xueling; Zhang, Zhenhai; Schramm, Chaim A. Cell, Vol. 161, Issue 3 https://doi.org/10.1016/j.cell.2015.03.004	journal	April 2015
The antigenic structure of the HIV gp120 envelope glycoprotein Wyatt, Richard; Kwong, Peter D.; Desjardins, Elizabeth Nature, Vol. 393, Issue 6686 https://doi.org/10.1038/31514	journal	June 1998
MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy Zheng, Shawn Q.; Palovcak, Eugene; Armache, Jean-Paul Nature Methods, Vol. 14, Issue 4 https://doi.org/10.1038/nmeth.4193	journal	February 2017
Are anti-HIV IgAs good guys or bad guys? Zhou, Mingkui; Ruprecht, Ruth M. Retrovirology, Vol. 11, Issue 1 https://doi.org/10.1186/s12977-014-0109-5	journal	December 2014
Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01 Zhou, T.; Georgiev, I.; Wu, X. Science, Vol. 329, Issue 5993 https://doi.org/10.1126/science.1192819	journal	July 2010
Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation Zhou, Tongqing; Doria-Rose, Nicole A.; Cheng, Cheng Cell Reports, Vol. 19, Issue 4 https://doi.org/10.1016/j.celrep.2017.04.013	journal	April 2017
A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope Zhou, Tongqing; Zheng, Anqi; Baxa, Ulrich Immunity, Vol. 48, Issue 3 https://doi.org/10.1016/j.immuni.2018.02.013	journal	March 2018
Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions Zhu, P.; Chertova, E.; Bess, J. Proceedings of the National Academy of Sciences, Vol. 100, Issue 26 https://doi.org/10.1073/pnas.2634931100	journal	December 2003
Distribution and three-dimensional structure of AIDS virus envelope spikes Zhu, Ping; Liu, Jun; Bess, Julian Nature, Vol. 441, Issue 7095 https://doi.org/10.1038/nature04817	journal	May 2006
Structure/Function Studies Involving the V3 Region of the HIV-1 Envelope Delineate Multiple Factors That Affect Neutralization Sensitivity Zolla-Pazner, Susan; Cohen, Sandra Sharpe; Boyd, David Journal of Virology, Vol. 90, Issue 2 https://doi.org/10.1128/JVI.01645-15	journal	October 2015

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