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Modular HIV-1 Capsid Assemblies Reveal Diverse Host-Capsid Recognition Mechanisms

Journal Article · · Cell Host & Microbe

Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Organization:
~OTHER
DOE Contract Number:
SC0012704
OSTI ID:
1783950
Report Number(s):
BNL-221481-2021-JACI
Journal Information:
Cell Host & Microbe, Vol. 26, Issue 2
Country of Publication:
United States
Language:
English

References (73)

PHENIX: a comprehensive Python-based system for macromolecular structure solution January 2010
CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction September 2017
Versatile C 3 -symmetric scaffolds and their use for covalent stabilization of the foldon trimer January 2014
Structural basis of HIV-1 capsid recognition by PF74 and CPSF6 December 2014
Structure of the rhesus monkey TRIM5  PRYSPRY domain, the HIV capsid recognition module July 2012
Using Lamm-Equation modeling of sedimentation velocity data to determine the kinetic and thermodynamic properties of macromolecular interactions May 2011
Calculations and Publication-Quality Illustrations for Analytical Ultracentrifugation Data January 2015
TRIMCyp expression in Old World primates Macaca nemestrina and Macaca fascicularis February 2008
The stoichiometry of Gag protein in HIV-1 June 2004
Host and Viral Determinants of Mx2 Antiretroviral Activity April 2014
Structural Convergence between Cryo-EM and NMR Reveals Intersubunit Interactions Critical for HIV-1 Capsid Function November 2009
Diverse HIV viruses are targeted by a conformationally dynamic antiviral March 2012
HIV-1 capsid: the multifaceted key player in HIV-1 infection July 2015
Microbatch crystallization under oil — a new technique allowing many small-volume crystallization trials August 1992
Simulated Self-Assembly of the HIV-1 Capsid: Protein Shape and Native Contacts Are Sufficient for Two-Dimensional Lattice Formation June 2011
The CCP4 suite programs for protein crystallography September 1994
A B-Box 2 Surface Patch Important for TRIM5α Self-Association, Capsid Binding Avidity, and Retrovirus Restriction August 2009
Variable Prevalence and Functional Diversity of the Antiretroviral Restriction Factor TRIMCyp in Macaca fascicularis July 2011
Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport April 2018
Maturation of the HIV-1 core by a non-diffusional phase transition January 2015
Specific incorporation of cyclophilin A into HIV-1 virions November 1994
Structural Insight into HIV-1 Restriction by MxB November 2014
MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1 August 2014
Structure of the Carboxyl-Terminal Dimerization Domain of the HIV-1 Capsid Protein October 1997
Assembly and Analysis of Conical Models for the HIV-1 Core January 1999
Hexagonal assembly of a restricting TRIM5  protein December 2010
Structure of Full-Length HIV-1 CA: A Model for the Mature Capsid Lattice October 2007
Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice June 2014
A Triple-Arginine Motif in the Amino-Terminal Domain and Oligomerization Are Required for HIV-1 Inhibition by Human MX2 February 2015
Transfer of the Amino-Terminal Nuclear Envelope Targeting Domain of Human MX2 Converts MX1 into an HIV-1 Resistance Factor June 2014
Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection September 2013
Unravelling the Molecular Basis of High Affinity Nanobodies against HIV p24: In Vitro Functional, Structural, and in Silico Insights June 2017
X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability June 2015
Early Stages of the HIV-1 Capsid Protein Lattice Formation October 2012
Integration, scaling, space-group assignment and post-refinement January 2010
FEZ1 Is Recruited to a Conserved Cofactor Site on Capsid to Promote HIV-1 Trafficking August 2019
XDS January 2010
MX2 is an interferon-induced inhibitor of HIV-1 infection October 2013
Image reconstructions of helical assemblies of the HIV-1 CA protein September 2000
The TRIM5α B-Box 2 Domain Promotes Cooperative Binding to the Retroviral Capsid by Mediating Higher-Order Self-Association September 2008
Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids June 2016
Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site March 2016
The Interferon-Inducible MxB Protein Inhibits HIV-1 Infection October 2013
Early cytoplasmic uncoating is associated with infectivity of HIV-1 August 2017
The structure and flexibility of conical HIV-1 capsids determined within intact virions December 2016
Phaser crystallographic software July 2007
Refinement of Macromolecular Structures by the Maximum-Likelihood Method May 1997
MxB Is Not Responsible for the Blocking of HIV-1 Infection Observed in Alpha Interferon-Treated Cells December 2015
Molecular Architecture of the Retroviral Capsid May 2016
UCSF Chimera?A visualization system for exploratory research and analysis January 2004
X-Ray Structures of the Hexameric Building Block of the HIV Capsid June 2009
Atomic-level modelling of the HIV capsid January 2011
Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly October 2014
Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1 July 2004
A Bayesian View on Cryo-EM Structure Determination January 2012
RELION: Implementation of a Bayesian approach to cryo-EM structure determination December 2012
Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling March 2000
Restriction of HIV-1 Requires the N-Terminal Region of MxB as a Capsid-Binding Motif but Not as a Nuclear Localization Signal June 2015
The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys February 2004
Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5  restriction factor March 2006
A Trimer of Dimers Is the Basic Building Block for Human Immunodeficiency Virus-1 Capsid Assembly May 2012
An approach to multi-copy search in molecular replacement December 2000
Size-Exclusion Chromatography with On-Line Light-Scattering, Absorbance, and Refractive Index Detectors for Studying Proteins and Their Interactions September 1996
Overview of the CCP 4 suite and current developments March 2011
Light scattering and the absolute characterization of macromolecules February 1993
Capsid-Dependent Host Factors in HIV-1 Infection September 2017
Structural insight into HIV-1 capsid recognition by rhesus TRIM5  October 2012
The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor October 2003
Conformational Adaptation of Asian Macaque TRIMCyp Directs Lineage Specific Antiviral Activity August 2010
Molecular recognition in the HIV-1 capsid/cyclophilin A complex 1 1Edited by J. A. Wells July 1997
Unclosed HIV-1 Capsids Suggest a Curled Sheet Model of Assembly January 2013
Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesin February 2012
Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics May 2013