The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase

Luz, J; Beigneux, A.; Asamoto, D.; He, C.; Song, W.; Allan, C.; Morales, J.; Tu, Y.; Kwok, A.; Cottle, T.; Meiyappan, M.; Fong, L.; Kim, J.; Ploug, M.; Young, S.; Birrane, G.

doi:10.1194/jlr.RA120000993

The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase

Journal Article · 01 January 2022 · Journal of Lipid Research

DOI:https://doi.org/10.1194/jlr.RA120000993· OSTI ID:1783948

Luz, J; Beigneux, A.; Asamoto, D.; He, C.; Song, W.; Allan, C.; Morales, J.; Tu, Y.; Kwok, A.; Cottle, T.; Meiyappan, M.; Fong, L.; Kim, J.; Ploug, M.; Young, S.; Birrane, G.

Research Organization:: Brookhaven National Lab. (BNL), Upton, NY (United States)

Sponsoring Organization:: ~OTHER

DOE Contract Number:: SC0012704

OSTI ID:: 1783948

Report Number(s):: BNL-221479-2021-JACI

Journal Information:: Journal of Lipid Research, Vol. 61, Issue 10

Country of Publication:: United States

Language:: English

References (42)

Detection and characterization of the heterozygote state for lipoprotein lipase deficiency. Babirak, S. P.; Iverius, P. H.; Fujimoto, W. Y. Arteriosclerosis: An Official Journal of the American Heart Association, Inc., Vol. 9, Issue 3 https://doi.org/10.1161/01.ATV.9.3.326	journal	May 1989
Detailed characterization of the binding site of the lipoprotein lipase-specific monoclonal antibody 5D2 Chang, Shau-Feng; Reich, Berthold; Brunzell, John D. Journal of Lipid Research, Vol. 39, Issue 12 https://doi.org/10.1016/S0022-2275(20)33314-9	journal	December 1998
Human lipoprotein lipase: relationship of activity, heparin affinity, and conformation as studied with monoclonal antibodies. Peterson, J.; Fujimoto, Wy; Brunzell, Jd Journal of Lipid Research, Vol. 33, Issue 8 https://doi.org/10.1016/S0022-2275(20)40768-0	journal	August 1992
Lipoprotein lipase domain function. Wong, H.; Davis, R. C.; Thuren, T. Journal of Biological Chemistry, Vol. 269, Issue 14 https://doi.org/10.1016/S0021-9258(17)34063-2	journal	April 1994
Mapping of the epitope on lipoprotein lipase recognized by a monoclonal antibody (5D2) which inhibits lipase activity Liu, Ming-Sun; Ma, Yuanhong; Hayden, Michael R. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol. 1128, Issue 1 https://doi.org/10.1016/0005-2760(92)90264-V	journal	September 1992
Mutation of Tryptophan Residues in Lipoprotein Lipase: EFFECTS ON STABILITY, IMMUNOREACTIVITY, AND CATALYTIC PROPERTIES Lookene, Aivar; Groot, Niels B.; Kastelein, John J. P. Journal of Biological Chemistry, Vol. 272, Issue 2 https://doi.org/10.1074/jbc.272.2.766	journal	January 1997
The carboxyl-terminal domain of lipoprotein lipase binds to the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP) and mediates binding of normal very low density lipoproteins to LRP. Williams, S. E.; Inoue, I.; Tran, H. Journal of Biological Chemistry, Vol. 269, Issue 12 https://doi.org/10.1016/S0021-9258(17)37017-5	journal	March 1994
The GPIHBP1–LPL Complex Is Responsible for the Margination of Triglyceride-Rich Lipoproteins in Capillaries Goulbourne, Chris N.; Gin, Peter; Tatar, Angelica Cell Metabolism, Vol. 19, Issue 5 https://doi.org/10.1016/j.cmet.2014.01.017	journal	May 2014
Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism Kristensen, Kristian K.; Leth-Espensen, Katrine Zinck; Mertens, Haydyn D. T. Proceedings of the National Academy of Sciences, Vol. 117, Issue 8 https://doi.org/10.1073/pnas.1920202117	journal	February 2020
Lipoprotein lipase from bovine milk. Isolation procedure, chemical characterization, and molecular weight analysis Iverius, P. H.; Ostlund-Lindqvist, A. M. Journal of Biological Chemistry, Vol. 251, Issue 24 https://doi.org/10.1016/S0021-9258(19)57004-1	journal	December 1976
Lipoprotein lipase: size of the functional unit determined by radiation inactivation Garfinkel, A. S.; Kempner, E. S.; Ben-Zeev, O. Journal of Lipid Research, Vol. 24, Issue 6 https://doi.org/10.1016/S0022-2275(20)37945-1	journal	June 1983
Molecular size of bovine lipoprotein lipase as determined by radiation inactivation. Olivecrona, T.; Bengtsson-Olivecrona, G.; Osborne, J. C. Journal of Biological Chemistry, Vol. 260, Issue 11 https://doi.org/10.1016/S0021-9258(18)88863-9	journal	June 1985
Rapid Subunit Exchange in Dimeric Lipoprotein Lipase and Properties of the Inactive Monomer Lookene, Aivar; Zhang, Liyan; Hultin, Magnus Journal of Biological Chemistry, Vol. 279, Issue 48 https://doi.org/10.1074/jbc.M407419200	journal	September 2004
Calcium Triggers Folding of Lipoprotein Lipase into Active Dimers Zhang, Liyan; Lookene, Aivar; Wu, Gengshu Journal of Biological Chemistry, Vol. 280, Issue 52 https://doi.org/10.1074/jbc.M507252200	journal	December 2005
Lipoprotein lipase: from gene to obesity Wang, Hong; Eckel, Robert H. American Journal of Physiology-Endocrinology and Metabolism, Vol. 297, Issue 2 https://doi.org/10.1152/ajpendo.90920.2008	journal	August 2009
Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue Sukonina, V.; Lookene, A.; Olivecrona, T. Proceedings of the National Academy of Sciences, Vol. 103, Issue 46 https://doi.org/10.1073/pnas.0604026103	journal	November 2006
Mechanisms of lipase maturation Doolittle, Mark H.; Péterfy, Miklós Clinical Lipidology, Vol. 5, Issue 1 https://doi.org/10.2217/clp.09.84	journal	February 2010
Lipoprotein lipase is active as a monomer Beigneux, Anne P.; Allan, Christopher M.; Sandoval, Norma P. Proceedings of the National Academy of Sciences, Vol. 116, Issue 13 https://doi.org/10.1073/pnas.1900983116	journal	March 2019
Structure of the lipoprotein lipase–GPIHBP1 complex that mediates plasma triglyceride hydrolysis Birrane, Gabriel; Beigneux, Anne P.; Dwyer, Brian Proceedings of the National Academy of Sciences, Vol. 116, Issue 5 https://doi.org/10.1073/pnas.1817984116	journal	December 2018
The structure of helical lipoprotein lipase reveals an unexpected twist in lipase storage Gunn, Kathryn H.; Roberts, Benjamin S.; Wang, Fengbin Proceedings of the National Academy of Sciences, Vol. 117, Issue 19 https://doi.org/10.1073/pnas.1916555117	journal	April 2020
Assessing the Role of the Glycosylphosphatidylinositol-anchored High Density Lipoprotein-binding Protein 1 (GPIHBP1) Three-finger Domain in Binding Lipoprotein Lipase Beigneux, Anne P.; Davies, Brandon S. J.; Tat, Shelly Journal of Biological Chemistry, Vol. 286, Issue 22 https://doi.org/10.1074/jbc.M111.242024	journal	April 2011
XDS Kabsch, Wolfgang Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2 https://doi.org/10.1107/S0907444909047337	journal	January 2010
Data processing and analysis with the autoPROC toolbox Vonrhein, Clemens; Flensburg, Claus; Keller, Peter Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4 https://doi.org/10.1107/S0907444911007773	journal	March 2011
Phaser crystallographic software McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D. Journal of Applied Crystallography, Vol. 40, Issue 4 https://doi.org/10.1107/S0021889807021206	journal	July 2007
Development of a therapeutic monoclonal antibody that targets secreted fatty acid–binding protein aP2 to treat type 2 diabetes Burak, M. Furkan; Inouye, Karen E.; White, Ariel Science Translational Medicine, Vol. 7, Issue 319 https://doi.org/10.1126/scitranslmed.aac6336	journal	December 2015
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix Liebschner, Dorothee; Afonine, Pavel V.; Baker, Matthew L. Acta Crystallographica Section D Structural Biology, Vol. 75, Issue 10 https://doi.org/10.1107/S2059798319011471	journal	October 2019
[20] Processing of X-ray diffraction data collected in oscillation mode Otwinowski, Zbyszek; Minor, Wladek Macromolecular Crystallography Part A, 307-326 https://doi.org/10.1016/S0076-6879(97)76066-X	book	January 1997
Molecular replacement with MOLREP Vagin, Alexei; Teplyakov, Alexei Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1 https://doi.org/10.1107/S0907444909042589	journal	December 2009
The Buccaneer software for automated model building. 1. Tracing protein chains Cowtan, Kevin Acta Crystallographica Section D Biological Crystallography, Vol. 62, Issue 9 https://doi.org/10.1107/S0907444906022116	journal	August 2006
Features and development of Coot Emsley, P.; Lohkamp, B.; Scott, W. G. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4 https://doi.org/10.1107/S0907444910007493	journal	March 2010
Refinement of Macromolecular Structures by the Maximum-Likelihood Method Murshudov, G. N.; Vagin, A. A.; Dodson, E. J. Acta Crystallographica Section D Biological Crystallography, Vol. 53, Issue 3 https://doi.org/10.1107/S0907444996012255	journal	May 1997
MolProbity: More and better reference data for improved all-atom structure validation: PROTEIN SCIENCE.ORG Williams, Christopher J.; Headd, Jeffrey J.; Moriarty, Nigel W. Protein Science, Vol. 27, Issue 1 https://doi.org/10.1002/pro.3330	journal	November 2017
How to measure and predict the molar absorption coefficient of a protein Pace, C. Nick; Vajdos, Felix; Fee, Lanette Protein Science, Vol. 4, Issue 11 https://doi.org/10.1002/pro.5560041120	journal	November 1995
Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions Krissinel, E.; Henrick, K. Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12 https://doi.org/10.1107/S0907444904026460	journal	November 2004
Overview of the CCP 4 suite and current developments Winn, Martyn D.; Ballard, Charles C.; Cowtan, Kevin D. Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4 https://doi.org/10.1107/S0907444910045749	journal	March 2011
Inference of Macromolecular Assemblies from Crystalline State Krissinel, Evgeny; Henrick, Kim Journal of Molecular Biology, Vol. 372, Issue 3 https://doi.org/10.1016/j.jmb.2007.05.022	journal	September 2007
An Analysis of Perturbations in the Ultraviolet Absorption Spectra of Proteins and Model Compounds Bailey, J. E.; Beaven, G. H.; Chignell, D. A. European Journal of Biochemistry, Vol. 7, Issue 1 https://doi.org/10.1111/j.1432-1033.1968.tb19566.x	journal	December 1968
An LPL–specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1 Allan, Christopher M.; Larsson, Mikael; Hu, Xuchen Journal of Lipid Research, Vol. 57, Issue 10 https://doi.org/10.1194/jlr.M070813	journal	October 2016
Tryptophan-Lipid Interactions in Membrane Protein Folding Probed by Ultraviolet Resonance Raman and Fluorescence Spectroscopy Sanchez, Katheryn M.; Kang, Guipeun; Wu, Beijing Biophysical Journal, Vol. 100, Issue 9 https://doi.org/10.1016/j.bpj.2011.03.018	journal	May 2011
Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity Zhang, G.; Cowled, C.; Shi, Z. Science, Vol. 339, Issue 6118 https://doi.org/10.1126/science.1230835	journal	December 2012
Comparison of Serum and Plasma for Determination of Blood Biochemical Values in Malaysian Flying Foxes (Pteropus Vampyrus) Heard, Darryl J.; Ruiz, Michele M.; Harr, Kendal E. Journal of Zoo and Wildlife Medicine, Vol. 37, Issue 3 https://doi.org/10.1638/02-064.1	journal	September 2006
POVScript+ : a program for model and data visualization using persistence of vision ray-tracing Fenn, T. D.; Ringe, D.; Petsko, G. A. Journal of Applied Crystallography, Vol. 36, Issue 3 https://doi.org/10.1107/S0021889803006721	journal	May 2003

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The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase

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