Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism

Journal Article · · Proceedings of the National Academy of Sciences of the United States of America

Research Organization:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Organization:
~OTHER
DOE Contract Number:
SC0012704
OSTI ID:
1783942
Report Number(s):
BNL-221473-2021-JACI
Journal Information:
Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, Issue 3
Country of Publication:
United States
Language:
English

References (56)

Mini-F plasmid genes that couple host cell division to plasmid proliferation. journal August 1983
Unique type of plasmid maintenance function: postsegregational killing of plasmid-free cells. journal May 1986
Mechanism of postsegregational killing by the hok gene product of the parB system of plasmid R1 and its homology with the relF gene product of the E. coli relB operon. journal August 1986
chpA and chpB, Escherichia coli chromosomal homologs of the pem locus responsible for stable maintenance of plasmid R100. journal November 1993
An Escherichia coli chromosomal "addiction module" regulated by guanosine [corrected] 3',5'-bispyrophosphate: a model for programmed bacterial cell death. journal June 1996
Autoinducer 2 Controls Biofilm Formation in Escherichia coli through a Novel Motility Quorum-Sensing Regulator (MqsR, B3022) journal December 2005
Gene expression in Escherichia coli biofilms journal May 2004
Characterization of the hipA7 allele of Escherichia coli and evidence that high persistence is governed by (p)ppGpp synthesis: Persistence and (p)ppGpp synthesis in E. coli journal November 2003
Toxin-Antitoxin Systems Influence Biofilm and Persister Cell Formation and the General Stress Response journal June 2011
Toxin-antitoxin systems in bacterial growth arrest and persistence journal March 2016
Mechanism of post-segregational killing: Sok antisense RNA interacts with Hok mRNA via its 5′-end single-stranded leader and competes with the 3′-end of Hok mRNA for binding to the mok translational initiation region. journal April 1994
Interactions of CcdB with DNA Gyrase journal April 1999
Bacterial Toxin HigB Associates with Ribosomes and Mediates Translation-dependent mRNA Cleavage at A-rich Sites journal May 2009
MazF Cleaves Cellular mRNAs Specifically at ACA to Block Protein Synthesis in Escherichia coli journal October 2003
The Bacterial Toxin RelE Displays Codon-Specific Cleavage of mRNAs in the Ribosomal A Site journal January 2003
Molecular Mechanism of Bacterial Persistence by HipA journal October 2013
Cell killing by the F plasmid CcdB protein involves poisoning of DNA-topoisomerase II complexes journal August 1992
Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology journal September 2015
The Toxin-Antitoxin System DarTG Catalyzes Reversible ADP-Ribosylation of DNA journal December 2016
Comprehensive comparative-genomic analysis of Type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes journal January 2009
Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution journal December 2009
Cell Growth Inhibition upon Deletion of Four Toxin-Antitoxin Loci from the Megaplasmids of Sinorhizobium meliloti journal February 2014
TADB: a web-based resource for Type 2 toxin–antitoxin loci in bacteria and archaea journal October 2010
Precursor-centric genome-mining approach for lasso peptide discovery journal September 2012
Toxin-Antitoxin Systems in Bacteria and Archaea journal December 2011
Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. journal July 1995
The Escherichia coli relBE genes belong to a new toxin-antitoxin gene family journal August 1998
Recombinant protein expression in Escherichia coli: advances and challenges journal April 2014
Bacterial toxin YafQ is an endoribonuclease that associates with the ribosome and blocks translation elongation through sequence-specific and frame-dependent mRNA cleavage journal March 2009
Characterization of the Interactions within the mazEF Addiction Module of Escherichia coli journal August 2003
Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry journal April 2012
Inference of Macromolecular Assemblies from Crystalline State journal September 2007
Searching protein structure databases with DaliLite v.3 journal September 2008
Cholix Toxin, a Novel ADP-ribosylating Factor from Vibrio cholerae journal February 2008
Exotoxin A–eEF2 complex structure indicates ADP ribosylation by ribosome mimicry journal August 2005
Role of Arginine in Protein Refolding, Solubilization, and Purification journal October 2004
Crystal Structure and Site-directed Mutagenesis of Enzymatic Components from Clostridium perfringens Iota-toxin journal January 2003
Characterization of the Enzymatic Component of Clostridium perfringens Iota-Toxin journal January 2000
Auto ADP‐ribosylation of NarE, a Neisseria meningitidis ADP‐ribosyltransferase, regulates its catalytic activities journal August 2013
Modification of the ADP-ribosyltransferase and NAD Glycohydrolase Activities of a Mammalian Transferase (ADP-ribosyltransferase 5) by Auto-ADP-ribosylation journal November 1999
The macro domain is an ADP-ribose binding module journal May 2005
Combining affinity purification by ADP-ribose-binding macro domains with mass spectrometry to define the mammalian ADP-ribosyl proteome journal February 2009
Structural analysis and classification of native proteins from E. coli commonly co-purified by immobilised metal affinity chromatography journal September 2006
Engineering Escherichia coli BL21(DE3) Derivative Strains To Minimize E. coli Protein Contamination after Purification by Immobilized Metal Affinity Chromatography journal May 2011
Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli journal June 2009
Combining Higher-Energy Collision Dissociation and Electron-Transfer/Higher-Energy Collision Dissociation Fragmentation in a Product-Dependent Manner Confidently Assigns Proteomewide ADP-Ribose Acceptor Sites journal January 2017
Inactivation of Escherichia coli Phosphoribosylpyrophosphate Synthetase by the 2′,3′-Dialdehyde Derivative of ATP journal September 1995
Catalytic residues Lys197 and Arg199 of Bacillus subtilis phosphoribosyl diphosphate synthase. Alanine-scanning mutagenesis of the flexible catalytic loop journal July 2005
Overexpression of the Normal Phosphoribosylpyrophosphate Synthetase 1 Isoform Underlies Catalytic Superactivity of Human Phosphoribosylpyrophosphate Synthetase journal August 1996
Three-dimensional structure of phosphoribosyl pyrophosphate synthetase from E. coli at 2.71 Å resolution journal January 2016
Primary structure of elongation factor Tu from Escherichia coli. journal March 1980
Novel bacterial ADP-ribosylating toxins: structure and function journal July 2014
Arginine ADP-ribosylation mechanism based on structural snapshots of iota-toxin and actin complex journal February 2013
Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens  -toxin journal May 2008
Covalent modification of the iron protein of nitrogenase from Rhodospirillum rubrum by adenosine diphosphoribosylation of a specific arginine residue. journal May 1985
ADP-Ribosylation, a Multifaceted Posttranslational Modification Involved in the Control of Cell Physiology in Health and Disease journal November 2017