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Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases

Journal Article · · Molecular Cell
Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Organization:
~OTHER
DOE Contract Number:
SC0012704
OSTI ID:
1783762
Report Number(s):
BNL-221444-2021-JACI
Journal Information:
Molecular Cell, Journal Name: Molecular Cell Journal Issue: 3 Vol. 81; ISSN 1097-2765
Country of Publication:
United States
Language:
English

References (78)

Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms journal May 2015
Origin and evolution of the RIG-I like RNA helicase gene family journal January 2009
The emerging roles of the DDX41 protein in immunity and diseases journal August 2016
Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity journal May 2019
Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling journal October 2017
TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity journal December 2016
LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling journal August 2015
Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response journal June 2012
MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability journal January 2013
The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells journal September 2011
A Distinct Role of Riplet-Mediated K63-Linked Polyubiquitination of the RIG-I Repressor Domain in Human Antiviral Innate Immune Responses journal August 2013
Site-Specific N- and C-Terminal Labeling of a Single Polypeptide Using Sortases of Different Specificity journal July 2009
Features and development of Coot journal March 2010
Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function journal March 2007
Highly efficient Cas9-mediated transcriptional programming journal March 2015
The Phyre2 web portal for protein modeling, prediction and analysis journal May 2015
Biogenesis of small RNAs in animals journal February 2009
Duplex RNA activated ATPases (DRAs): Platforms for RNA sensing, signaling and processing journal January 2013
Automated electron microscope tomography using robust prediction of specimen movements journal October 2005
TRIM14 is a mitochondrial adaptor that facilitates retinoic acid-inducible gene-I-like receptor-mediated innate immune response journal December 2013
Lysine Methylation as a Routine Rescue Strategy for Protein Crystallization journal November 2006
Exploring the diversity of SPRY/B30.2-mediated interactions journal January 2013
The RIG-I-like Receptor LGP2 Controls CD8+ T Cell Survival and Fitness journal August 2012
Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5 journal January 2013
Phaser crystallographic software journal July 2007
Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide journal October 2016
Structural determinants of TRIM protein function journal February 2017
A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis journal January 2019
The Salmonella Effector Protein SopA Modulates Innate Immune Responses by Targeting TRIM E3 Ligase Family Members journal April 2016
Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity: SPRY/B30.2 Domain Proteins journal December 2012
The cytosolic sensor, DDX41, activates antiviral and inflammatory immunity in response to stimulation with double-stranded DNA adherent cells of the olive flounder, Paralichthys olivaceus journal June 2015
Structural Basis for Protein Recognition by B30.2/SPRY Domains journal December 2006
LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses journal January 2010
Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I journal March 2014
Paramyxovirus V Proteins Disrupt the Fold of the RNA Sensor MDA5 to Inhibit Antiviral Signaling journal January 2013
InTRIMsic immunity: Positive and negative regulation of immune signaling by tripartite motif proteins journal October 2014
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix journal October 2019
Structural Insights into RNA Recognition by RIG-I journal October 2011
Negative staining and image classification — powerful tools in modern electron microscopy journal January 2004
Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling journal March 2014
New tools for automated high-resolution cryo-EM structure determination in RELION-3 journal November 2018
CTFFIND4: Fast and accurate defocus estimation from electron micrographs journal November 2015
RIPLET, and not TRIM25, is required for endogenous RIG‐I‐dependent antiviral responses journal August 2019
New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0 journal March 2010
Structural basis of RNA recognition and activation by innate immune receptor RIG-I journal September 2011
Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation journal February 2018
Recognition of viral nucleic acids in innate immunity: Virus-recognition by PRRs journal December 2009
An origin of the immunogenicity of in vitro transcribed RNA journal March 2018
TRIM family proteins and their emerging roles in innate immunity journal November 2008
Slicing and dicing viruses: antiviral RNA interference in mammals journal March 2019
Structure and Mechanism of Helicases and Nucleic Acid Translocases journal June 2007
The DEAD-box RNA helicase DDX41 is a novel repressor of p21WAF1/CIP1 mRNA translation journal May 2017
UCSF Chimera?A visualization system for exploratory research and analysis journal January 2004
MolProbity: More and better reference data for improved all-atom structure validation: PROTEIN SCIENCE.ORG journal November 2017
XDS journal January 2010
RNase III nucleases from diverse kingdoms serve as antiviral effectors journal June 2017
ProtTest 3: fast selection of best-fit models of protein evolution journal February 2011
Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5 journal May 2016
TimeTree: A Resource for Timelines, Timetrees, and Divergence Times journal April 2017
Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition journal December 2011
Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity journal April 2010
Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA journal October 2011
Evolution of MDA-5/RIG-I-dependent innate immunity: Independent evolution by domain grafting journal October 2008
Iterative model building, structure refinement and density modification with the PHENIX AutoBuild wizard journal December 2007
E3 ubiquitin ligases, the powerful modulator of innate antiviral immunity journal June 2019
Molecular Imprinting as a Signal-Activation Mechanism of the Viral RNA Sensor RIG-I journal August 2014
Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity journal May 2017
RIG-I Forms Signaling-Competent Filaments in an ATP-Dependent, Ubiquitin-Independent Manner journal September 2013
Double-Stranded RNA Sensors and Modulators in Innate Immunity journal April 2019
Optimal Determination of Particle Orientation, Absolute Hand, and Contrast Loss in Single-particle Electron Cryomicroscopy journal October 2003
Evolution of the Class 2 cytokines and receptors, and discovery of new friends and relatives journal June 2005
RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination journal January 2014
MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy journal February 2017
Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis journal December 2018
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity journal March 2007
Loss of DExD/H Box RNA Helicase LGP2 Manifests Disparate Antiviral Responses journal May 2007
The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response journal November 2012
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs journal September 1997

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