Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Conformational Plasticity in Human Heme-Based Dioxygenases

Journal Article · · Journal of the American Chemical Society
DOI:https://doi.org/10.1021/jacs.0c09970· OSTI ID:1783759

Research Organization:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Organization:
~OTHER
DOE Contract Number:
SC0012704
OSTI ID:
1783759
Report Number(s):
BNL-221441-2021-JACI
Journal Information:
Journal of the American Chemical Society, Vol. 143, Issue 4
Country of Publication:
United States
Language:
English

References (67)

A short history of heme dioxygenases: rise, fall and rise again journal December 2016
Heme-Containing Oxygenases journal January 1996
Heme-dependent dioxygenases in tryptophan oxidation journal February 2014
Kynurenine Pathway Metabolites in Humans: Disease and Healthy States journal January 2009
Quinolinic acid and Kynurenine Pathway Metabolism in Inflammatory and Non-Inflammatory Neurological Disease journal January 1992
The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease journal June 2011
Kynurenine pathway abnormalities in Parkinson's disease journal September 1992
Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice journal January 2009
Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection journal August 2002
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase journal September 2003
Why tumours eat tryptophan journal October 2011
Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase journal January 2012
Crystal structure of human indoleamine 2,3-dioxygenase: Catalytic mechanism of O2 incorporation by a heme-containing dioxygenase journal February 2006
Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase journal October 2016
Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1 journal November 2017
Evidence for a ferryl intermediate in a heme-based dioxygenase journal September 2009
The first step of the dioxygenation reaction carried out by tryptophan dioxygenase and indoleamine 2,3-dioxygenase as revealed by quantum mechanical/molecular mechanical studies journal April 2010
Complete Reaction Mechanism of Indoleamine 2,3-Dioxygenase as Revealed by QM/MM Simulations journal January 2012
ONIOM Study on a Missing Piece in Our Understanding of Heme Chemistry: Bacterial Tryptophan 2,3-Dioxygenase with Dual Oxidants journal September 2010
Probing the Ternary Complexes of Indoleamine and Tryptophan 2,3-Dioxygenases by Cryoreduction EPR and ENDOR Spectroscopy journal April 2010
The Mechanism of Formation of N -Formylkynurenine by Heme Dioxygenases journal October 2011
Identification of the Fe–O 2 and the Fe=O Heme Species for Indoleamine 2,3-Dioxygenase during Catalytic Turnover journal January 2010
Enzyme Reactivation by Hydrogen Peroxide in Heme-based Tryptophan Dioxygenase journal July 2011
Inhibition Mechanisms of Human Indoleamine 2,3 Dioxygenase 1 journal June 2018
Human Tryptophan Dioxygenase:  A Comparison to Indoleamine 2,3-Dioxygenase journal December 2007
Effects of tryptophan and pH on the kinetics of superoxide radical binding to indoleamine 2,3-dioxygenase studied by pulse radiolysis journal September 1989
Studies on indoleamine 2,3-dioxygenase. I. Superoxide anion as substrate. journal August 1975
Intracellular utilization of superoxide anion by indoleamine 2,3-dioxygenase of rabbit enterocytes. journal April 1977
Spectroscopic Studies of Ligand and Substrate Binding to Human Indoleamine 2,3-Dioxygenase journal June 2010
Substrate Binding Primes Human Tryptophan 2,3-Dioxygenase for Ligand Binding journal July 2017
Crystal structure of CO-bound cytochrome c oxidase determined by serial femtosecond X-ray crystallography at room temperature journal July 2017
Bovine cytochrome c oxidase structures enable O 2 reduction with minimization of reactive oxygens and provide a proton-pumping gate journal April 2010
Mapping the Binding Trajectory of a Suicide Inhibitor in Human Indoleamine 2,3-Dioxygenase 1 journal October 2018
Structural Study of a Flexible Active Site Loop in Human Indoleamine 2,3-Dioxygenase and Its Functional Implications journal May 2016
Molecular Basis for the Substrate Stereoselectivity in Tryptophan Dioxygenase journal December 2011
Influence of the presence of the heme cofactor on the JK-loop structure in indoleamine 2,3-dioxygenase 1 journal November 2020
Ligand and Substrate Migration in Human Indoleamine 2,3-Dioxygenase journal November 2009
The Mechanism of Substrate Inhibition in Human Indoleamine 2,3-Dioxygenase journal February 2012
Conformational substates in a protein: structure and dynamics of metmyoglobin at 80 K. journal August 1982
Watching a Protein as it Functions with 150-ps Time-Resolved X-ray Crystallography journal June 2003
Photolysis of the Carbon Monoxide Complex of Myoglobin: Nanosecond Time-Resolved Crystallography journal December 1996
Structure of a ligand-binding intermediate in wild-type carbonmonoxy myoglobin journal February 2000
Ligand binding and conformational motions in myoglobin journal March 2000
Stereochemistry of carbonylmetalloporphyrins. The structure of (pyridine)(carbonyl)(5,10,15,20-tetraphenylporphinato)iron(II) journal December 1976
Binding of CO to myoglobin from a heme pocket docking site to form nearly linear Fe-C-O journal August 1995
Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1 H -indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate journal November 2017
First-in-Human Phase I Study of the Oral Inhibitor of Indoleamine 2,3-Dioxygenase-1 Epacadostat (INCB024360) in Patients with Advanced Solid Malignancies journal January 2017
Abstract 491: NLG919, a novel indoleamine-2,3-dioxygenase (IDO)-pathway inhibitor drug candidate for cancer therapy. conference November 2014
The Heme Environment of Recombinant Human Indoleamine 2,3-Dioxygenase journal May 2002
Structural Basis of Inhibitor Selectivity in Human Indoleamine 2,3-Dioxygenase 1 and Tryptophan Dioxygenase journal November 2019
Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1 journal December 2015
Substrate stereo-specificity in tryptophan dioxygenase and indoleamine 2,3-dioxygenase: Substrate Stereoselectivity in TDO and IDO journal July 2010
CO as a vibrational probe of heme protein active sites journal January 2005
Structural and functional properties of hemoglobins from unicellular organisms as revealed by resonance Raman spectroscopy journal January 2005
The Role of Serine 167 in Human Indoleamine 2,3-Dioxygenase: A Comparison with Tryptophan 2,3-Dioxygenase journal April 2008
Substrate−Protein Interaction in Human Tryptophan Dioxygenase: The Critical Role of H76 journal March 2009
Interactions between Nitric Oxide and Indoleamine 2,3-Dioxygenase journal July 2006
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
How good are my data and what is the resolution? journal June 2013
Linking Crystallographic Model and Data Quality journal May 2012
Phaser crystallographic software journal July 2007
Overview of the CCP 4 suite and current developments journal March 2011
Coot model-building tools for molecular graphics journal November 2004
REFMAC 5 for the refinement of macromolecular crystal structures journal March 2011
Refinement of Macromolecular Structures by the Maximum-Likelihood Method journal May 1997
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix journal October 2019
Polder maps: improving OMIT maps by excluding bulk solvent journal February 2017

Similar Records

Related Subjects