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Structure-Based Drug Design of Phenazopyridine Derivatives as Inhibitors of Rev1 Interactions in Translesion Synthesis

Journal Article · · ChemMedChem

Research Organization:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Organization:
~OTHER
DOE Contract Number:
SC0012704
OSTI ID:
1783738
Report Number(s):
BNL-221420-2021-JACI
Journal Information:
ChemMedChem, Vol. 16, Issue 7; ISSN 1860-7179
Publisher:
ChemPubSoc Europe
Country of Publication:
United States
Language:
English

References (42)

Cisplatin: mode of cytotoxic action and molecular basis of resistance journal October 2003
The resurgence of platinum-based cancer chemotherapy journal July 2007
Cellular processing of platinum anticancer drugs journal March 2005
Cisplatin in cancer therapy: Molecular mechanisms of action journal October 2014
Rethinking Alkylating(-Like) Agents for Solid Tumor Management journal May 2019
Molecular mechanisms of cisplatin resistance journal September 2011
Multiple Repair Pathways Mediate Tolerance to Chemotherapeutic Cross-linking Agents in Vertebrate Cells journal December 2005
Error-prone translesion synthesis mediates acquired chemoresistance journal November 2010
Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics journal July 2016
Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy? journal August 2017
Translesion DNA Synthesis in Cancer: Molecular Mechanisms and Therapeutic Opportunities journal September 2017
DNA polymerases and cancer journal January 2011
Translesion DNA synthesis in the context of cancer research journal January 2011
Y-family DNA polymerases and their role in tolerance of cellular DNA damage journal February 2012
Translesion DNA polymerases in eukaryotes: what makes them tick? journal January 2017
Translesion and Repair DNA Polymerases: Diverse Structure and Mechanism journal June 2018
Melanoma cells replicate through chemotherapy by reducing levels of key homologous recombination protein RAD51 and increasing expression of translesion synthesis DNA polymerase ζ journal December 2017
Expression of DNA Translesion Synthesis Polymerase η in Head and Neck Squamous Cell Cancer Predicts Resistance to Gemcitabine and Cisplatin-Based Chemotherapy journal December 2013
Multiple two-polymerase mechanisms in mammalian translesion DNA synthesis journal February 2010
Evidence for a second function for Saccharomyces cerevisiae Rev1p: A second function for Rev1p journal August 2000
Ubiquitin-Binding Domains in Y-Family Polymerases Regulate Translesion Synthesis journal December 2005
Identification of a novel REV1-interacting motif necessary for DNA polymerase κ function journal February 2009
NMR Structure and Dynamics of the C-Terminal Domain from Human Rev1 and Its Complex with Rev1 Interacting Region of DNA Polymerase η journal June 2012
Multifaceted Recognition of Vertebrate Rev1 by Translesion Polymerases ζ and κ journal June 2012
Structural Basis of Recruitment of DNA Polymerase ζ by Interaction between REV1 and REV7 Proteins journal August 2012
The C-terminal domain of human Rev1 contains independent binding sites for DNA polymerase η and Rev7 subunit of polymerase ζ journal July 2012
Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis journal March 2016
Identification of Small Molecule Translesion Synthesis Inhibitors That Target the Rev1-CT/RIR Protein−Protein Interaction journal June 2017
Small molecule scaffolds that disrupt the Rev1-CT/RIR protein-protein interaction journal August 2018
Structural Approach To Identify a Lead Scaffold That Targets the Translesion Synthesis Polymerase Rev1 journal October 2018
Virtual Pharmacophore Screening Identifies Small‐Molecule Inhibitors of the Rev1‐CT/RIR Protein–Protein Interaction journal August 2019
A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy journal June 2019
Control of the Structure and Functions of Biomaterials by Light journal March 1996
pH-Dependent cis → trans Isomerization Rates for Azobenzene Dyes in Aqueous Solution journal July 2009
The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair journal August 1998
Crystal Structure of Human REV7 in Complex with a Human REV3 Fragment and Structural Implication of the Interaction between DNA Polymerase ζ and REV1 journal February 2010
Rev7 dimerization is important for assembly and function of the Rev1/Polζ translesion synthesis complex journal August 2018
Structural insights into the assembly of human translesion polymerase complexes journal November 2012
Aromatic interactions at the ligand-protein interface: Implications for the development of docking scoring functions journal August 2017
Effects of Heteroatoms on Aromatic π−π Interactions: Benzene−Pyridine and Pyridine Dimer journal February 2009
Protein-binding assays in biological liquids using microscale thermophoresis journal October 2010
Overview of the CCP 4 suite and current developments journal March 2011