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Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility

Journal Article · · J. Mol. Cell. Cardiol.
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Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1779009
Journal Information:
J. Mol. Cell. Cardiol., Vol. 156
Country of Publication:
United States
Language:
ENGLISH

References (48)

Phosphorylation and function of cardiac myosin binding protein-C in health and disease May 2010
In the Thick of It: HCM-Causing Mutations in Myosin Binding Proteins of the Thick Filament March 2011
Myocardial Infarction-induced N-terminal Fragment of Cardiac Myosin-binding Protein C (cMyBP-C) Impairs Myofilament Function in Human Myocardium March 2014
Cardiac MyBP-C Regulates the Rate and Force of Contraction in Mammalian Myocardium January 2015
Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filaments February 2017
Molecular Mechanics of Cardiac Myosin-Binding Protein C in Native Thick Filaments August 2012
Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism January 2014
Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury April 2019
Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction January 2012
An Endogenously Produced Fragment of Cardiac Myosin-Binding Protein C Is Pathogenic and Can Lead to Heart Failure August 2013
MYBPC3 truncation mutations enhance actomyosin contractile mechanics in human hypertrophic cardiomyopathy February 2019
Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro April 2012
Surviving the infarct: A profile of cardiac myosin binding protein‐C pathogenicity, diagnostic utility, and proteomics in the ischemic myocardium July 2014
Myosin-Binding Protein C Phosphorylation, Myofibril Structure, and Contractile Function During Low-Flow Ischemia February 2005
Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain January 2012
Cardiac myosin binding protein c phosphorylation is cardioprotective October 2006
Alterations in Multi‐Scale Cardiac Architecture in Association With Phosphorylation of Myosin Binding Protein‐C March 2016
Activation of Myocardial Contraction by the N-Terminal Domains of Myosin Binding Protein-C May 2006
AAV9 gene transfer of cMyBPC N-terminal domains ameliorates cardiomyopathy in cMyBPC-deficient mice September 2020
Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation January 2017
Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice November 1999
Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy May 2019
Phosphorylation of cardiac myosin–binding protein-C contributes to calcium homeostasis August 2020
Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes May 2016
Protein Kinase A–Mediated Phosphorylation of cMyBP-C Increases Proximity of Myosin Heads to Actin in Resting Myocardium August 2008
Radial Displacement of Myosin Cross-bridges in Mouse Myocardium due to Ablation of Myosin Binding Protein-C March 2007
Hypertrophic Cardiomyopathy in Cardiac Myosin Binding Protein-C Knockout Mice March 2002
Structure and Interactions of Myosin-binding Protein C Domain C0 April 2011
Determination of the critical residues responsible for cardiac myosin binding protein C's interactions December 2012
cAPK-phosphorylation controls the interaction of the regulatory domain of cardiac myosin binding protein C with myosin-S2 in an on-off fashion June 1999
In vivo definition of cardiac myosin-binding protein C’s critical interactions with myosin August 2016
Acceleration of Crossbridge Kinetics by Protein Kinase A Phosphorylation of Cardiac Myosin Binding Protein C Modulates Cardiac Function October 2008
N-terminal fragment of cardiac myosin binding protein-C triggers pro-inflammatory responses in vitro October 2016
Hypercontractile Properties of Cardiac Muscle Fibers in a Knock-in Mouse Model of Cardiac Myosin-binding Protein-C February 2001
Normal cardiac contraction in mice lacking the proline–alanine rich region and C1 domain of cardiac myosin binding protein C November 2015
Direct visualization of myosin-binding protein C bridging myosin and actin filaments in intact muscle June 2011
The N terminus of myosin-binding protein C extends toward actin filaments in intact cardiac muscle February 2021
Ablation of Cardiac Myosin-Binding Protein-C Accelerates Stretch Activation in Murine Skinned Myocardium May 2006
Effect of extraction of myosin binding protein C on contractility of rat heart August 2003
Effects of the N-terminal Domains of Myosin Binding Protein-C in an in Vitro Motility Assay November 2006
Myosin Binding Protein C Positioned to Play a Key Role in Regulation of Muscle Contraction: Structure and Interactions of Domain C1 December 2008
Cardiac myosin-binding protein C decorates F-actin: Implications for cardiac function November 2008
Small-Angle X-ray Scattering Reveals the N-Terminal Domain Organization of Cardiac Myosin Binding Protein C April 2008
The Myosin-binding Protein C Motif Binds to F-actin in a Phosphorylation-sensitive Manner May 2009
Binding of the N-terminal fragment C0–C2 of cardiac MyBP-C to cardiac F-actin April 2011
Effects of Cardiac Myosin Binding Protein-C on Actin Motility Are Explained with a Drag-Activation-Competition Model January 2015
Revealing the mechanism of how cardiac myosin-binding protein C N-terminal fragments sensitize thin filaments for myosin binding March 2019
Contribution of the Myosin Binding Protein C Motif to Functional Effects in Permeabilized Rat Trabeculae October 2008

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