Non-coding RNAs linked to immortality and associated methods and compositions

Patent · 21 December 2020

OSTI ID:1771741

Stampfer, Martha R.; Garbe, James C.; Vrba, Lukas; Futscher, Bernard W.

Aspects of the present disclosure include RNAs that confer a mortal phenotype and nucleic acids encoding same. Liposomes, recombinant cells, and pharmaceutical compositions that include the RNAs or nucleic acids encoding same are also provided. Further provided are methods involving quantifying MORT RNAs and/or determining the methylation status of the MORT promoter, as well as methods that employ the RNAs or nucleic acids encoding same.

• Research Organization: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC02-05CH11231
• Assignee: THThe Regents of the University of California (Oakland, CA); Arizona Board of Regents on Behalf of the University of Arizona (Tucson, AZ)
• Patent Number(s): 10,870,851
• Application Number: 15/764,255
• OSTI ID: 1771741
• Country of Publication: United States
• Language: English