Dynamically-adaptive live therapeutic agents and methods of use thereof

Yung, Mimi Cho; Coleman, Matthew A.; D'Haeseleer, Patrik; Harris, Howard; Jiao, Yongqin; Overton, Kenneth W.; Park, Dan Mcfarland; Segelke, Brent W.; Wong, Sergio E.

Dynamically-adaptive live therapeutic agents and methods of use thereof

Patent · 20 October 2020

OSTI ID:1771529

Yung, Mimi Cho; Coleman, Matthew A.; D'Haeseleer, Patrik; Harris, Howard; Jiao, Yongqin; Overton, Kenneth W.; Park, Dan Mcfarland; Segelke, Brent W.; Wong, Sergio E.

This disclosure provides microbes engineered to detect virulent and spore states of pathogens and release an appropriate therapeutic response accordingly and compositions and methods of use of the same.

Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC52-07NA27344

Assignee:: Lawrence Livermore National Security, LLC (Livermore, CA)

Patent Number(s):: 10,808,232

Application Number:: 15/438,638

OSTI ID:: 1771529

Country of Publication:: United States

Language:: English

References (11)

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Clostridium difficile—A continually evolving and problematic pathogen Dawson, Lisa F.; Valiente, Esmeralda; Wren, Brendan W. Infection, Genetics and Evolution, Vol. 9, Issue 6 https://doi.org/10.1016/j.meegid.2009.06.005	journal	December 2009
Clostridium difficile spore biology: sporulation, germination, and spore structural proteins Paredes-Sabja, Daniel; Shen, Aimee; Sorg, Joseph A. Trends in Microbiology, Vol. 22, Issue 7 https://doi.org/10.1016/j.tim.2014.04.003	journal	July 2014

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