Poly(lactic-co-glycolic acid) Nanoparticles as Delivery Systems for the Improved Administration of Radiotherapeutic Anticancer Agents

Ambrogio, Michael W.; Toro-González, Miguel; Keever, Tamara J.; McKnight, Timothy E.; Davern, Sandra M.

doi:10.1021/acsanm.0c02350

Title: Poly(lactic-co-glycolic acid) Nanoparticles as Delivery Systems for the Improved Administration of Radiotherapeutic Anticancer Agents

Journal Article · Tue Oct 27 00:00:00 EDT 2020 · ACS Applied Nano Materials

DOI:https://doi.org/10.1021/acsanm.0c02350· OSTI ID:1763490

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Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

This letter reports the development of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) as delivery systems that could potentially encapsulate and improve the administration of radiotherapeutic anticancer agents. Different metal ions (Ba, Gd, and Ce) were used as surrogates of α-emitting radionuclides (²²³Ra, ²²⁵Ac, and ²²⁷Th), and their encapsulation within the PLGA NPs (D_h < 300 nm) was evaluated. The initial concentration of metal ions, the metal salt (nitrate vs chloride), and the presence of chelators influenced the concentration of surrogate ions within the PLGA NPs. This letter shows the potential of PLGA NPs to encapsulate radionuclides, particularly α-emitters, for their application in nuclear medicine.

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Research Organization:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC05-00OR22725; CNMS-2019-241

OSTI ID:: 1763490

Journal Information:: ACS Applied Nano Materials, Vol. 3, Issue 11; ISSN 2574-0970

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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nanoparticles
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targeted α-therapy
poly(lactic-co-glycolic acid)
radionuclides

Title: Poly(lactic-co-glycolic acid) Nanoparticles as Delivery Systems for the Improved Administration of Radiotherapeutic Anticancer Agents

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