Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by h

Journal Article · · FASEB J.
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; NIH
DOE Contract Number:
NONE;
OSTI ID:
1763083
Journal Information:
FASEB J., Journal Name: FASEB J. Journal Issue: (2) Vol. 35
Country of Publication:
United States
Language:
ENGLISH

References (42)

Synthesis of Unsymmetric Diphospho-Inositol Polyphosphates journal May 2013
Synthesis of Densely Phosphorylated Bis-1,5-Diphospho- myo -Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P-Anhydride Formation journal July 2014
Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling journal June 2017
Crystal structure of human diphosphoinositol phosphatase 1 journal October 2009
Refinement by shifting secondary structure elements improves sequence alignments: Refinement by Shifting Secondary Structure Elements journal January 2015
The evolution of function within the Nudix homology clan: Function Evolution in the Nudix Homology Clan journal March 2017
The complex enzymology of mRNA decapping: Enzymes of four classes cleave pyrophosphate bonds journal October 2018
Characterizing Enzymes of the Diphosphoinositol Polyphosphate Phosphohydrolase (DIPP) Family book November 2019
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
Structures and mechanisms of Nudix hydrolases journal January 2005
Oxidation of the diphosphoinositol polyphosphate phosphohydrolase-like Nudix hydrolase Aps from Drosophila melanogaster induces thermolability—A possible regulatory switch? journal July 2010
Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug Discovery journal May 2014
Understanding inositol pyrophosphate metabolism and function: Kinetic characterization of the DIPPs journal September 2013
A two-way switch for inositol pyrophosphate signaling: Evolutionary history and biological significance of a unique, bifunctional kinase/phosphatase journal January 2020
Structure and Mechanism of GDP-Mannose Glycosyl Hydrolase, a Nudix Enzyme that Cleaves at Carbon Instead of Phosphorus journal June 2004
Inositol Pyrophosphate Specificity of the SPX-Dependent Polyphosphate Polymerase VTC journal February 2017
Mechanism of the Escherichia coli ADP-Ribose Pyrophosphatase, a Nudix Hydrolase † , ‡ journal July 2002
Phosphonates as analogues of natural phosphates journal June 1977
α-Functionalized Phosphonylphosphinates:  Synthesis and Evaluation as Transcarbamoylase Inhibitors journal July 1999
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding journal November 2011
Synthesis of 2-diphospho-myo-inositol 1,3,4,5,6-pentakisphosphate and a photocaged analogue journal January 2016
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate journal January 2018
The use of phosphate bioisosteres in medicinal chemistry and chemical biology journal January 2012
Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolases journal July 2003
Diphospho-myo-inositol phosphates during the life cycle of Dictyostelium and Polysphondylium: Diphosphoinositol polyphosphates in dictyostelides journal April 2000
Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinases journal January 2005
Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling journal April 2020
Electrostatic steering and ionic tethering in enzyme-ligand binding: Insights from simulations journal May 1998
The MutT Proteins or “Nudix” Hydrolases, a Family of Versatile, Widely Distributed, “Housecleaning” Enzymes journal October 1996
Site-directed Mutagenesis of Diphosphoinositol Polyphosphate Phosphohydrolase, a Dual Specificity NUDT Enzyme That Attacks Diadenosine Polyphosphates and Diphosphoinositol Polyphosphates journal December 1999
Discovery of Molecular and Catalytic Diversity among Human Diphosphoinositol-Polyphosphate Phosphohydrolases: AN EXPANDING NUDT FAMILY journal April 2000
A Novel Inositol Pyrophosphate Phosphatase in Saccharomyces cerevisiae : Siw14 PROTEIN SELECTIVELY CLEAVES THE β-PHOSPHATE FROM 5-DIPHOSPHOINOSITOL PENTAKISPHOSPHATE (5PP-IP journal January 2016
Inositol Diphosphate Signaling Regulates Telomere Length journal November 2004
Structural and biochemical characterization of Siw14: A protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates journal May 2018
The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export journal June 2019
A novel context for the `MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase journal November 1998
The enzymes of human diphosphoinositol polyphosphate metabolism journal November 2013
Modification at C2 of myo-inositol 1,4,5-trisphosphate produces inositol trisphosphates and tetrakisphosphates with potent biological activities journal July 1994
Capture of a third Mg2+ is essential for catalyzing DNA synthesis journal June 2016
Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases journal January 2002
Disentangling the genetics of sarcopenia: prioritization of NUDT3 and KLF5 as genes for lean mass & HLA-DQB1-AS1 for hand grip strength with the associated enhancing SNPs & a scoring system journal February 2020
The Obesity-Linked Gene Nudt3 Drosophila Homolog Aps Is Associated With Insulin Signaling journal September 2015

Similar Records

Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding
Journal Article · 2012 · Nature Chemical Biology · OSTI ID:1033023

Inositol phospholipid hydrolysis in cultured astrocytes and oligodendrocytes
Journal Article · 1987 · Life Sci.; (United States) · OSTI ID:6500898

Cellular Cations Control Conformational Switching of Inositol Pyrophosphate Analogues
Journal Article · 2016 · Chem.-Eur. J. · OSTI ID:1855454

Related Subjects