Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase

Herbst-Gervasoni, C; Steimbach, R.; Morgen, M.; Miller, A.; Christianson, D.

doi:10.1021/acschembio.0c00362

Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase

Journal Article · 01 January 2022 · ACS Chemical Biology

DOI:https://doi.org/10.1021/acschembio.0c00362· OSTI ID:1690194

Herbst-Gervasoni, C; Steimbach, R.; Morgen, M.; Miller, A.; Christianson, D.

Research Organization:: Brookhaven National Lab. (BNL), Upton, NY (United States)

Sponsoring Organization:: ~OTHER

DOE Contract Number:: SC0012704

OSTI ID:: 1690194

Report Number(s):: BNL-220515-2020-JACI

Journal Information:: ACS Chemical Biology, Vol. 15, Issue 8

Country of Publication:: United States

Language:: English

References (30)

Molecular Evolution of the Histone Deacetylase Family: Functional Implications of Phylogenetic Analysis Gregoretti, IvanV; Lee, Yun-Mi; Goodson, Holly V. Journal of Molecular Biology, Vol. 338, Issue 1 https://doi.org/10.1016/j.jmb.2004.02.006	journal	April 2004
The many roles of histone deacetylases in development and physiology: implications for disease and therapy Haberland, Michael; Montgomery, Rusty L.; Olson, Eric N. Nature Reviews Genetics, Vol. 10, Issue 1 https://doi.org/10.1038/nrg2485	journal	January 2009
Structure, mechanism, and inhibition of the zinc-dependent histone deacetylases Porter, Nicholas J.; Christianson, David W. Current Opinion in Structural Biology, Vol. 59 https://doi.org/10.1016/j.sbi.2019.01.004	journal	December 2019
Polyamine Deacetylase Structure and Catalysis: Prokaryotic Acetylpolyamine Amidohydrolase and Eukaryotic HDAC10 Shinsky, Stephen A.; Christianson, David W. Biochemistry, Vol. 57, Issue 22 https://doi.org/10.1021/acs.biochem.8b00079	journal	March 2018
Histone deacetylase 10 structure and molecular function as a polyamine deacetylase Hai, Yang; Shinsky, Stephen A.; Porter, Nicholas J. Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/ncomms15368	journal	May 2017
Structure of a unique binuclear manganese cluster in arginase Kanyo, Zoltan F.; Scolnick, Laura R.; Ash, David E. Nature, Vol. 383, Issue 6600 https://doi.org/10.1038/383554a0	journal	October 1996
Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors Finnin, Michael S.; Donigian, Jill R.; Cohen, Alona Nature, Vol. 401, Issue 6749 https://doi.org/10.1038/43710	journal	September 1999
Arginase: Structure, Mechanism, and Physiological Role in Male and Female Sexual Arousal Christianson, David W. Accounts of Chemical Research, Vol. 38, Issue 3 https://doi.org/10.1021/ar040183k	journal	February 2005
Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes Lombardi, Patrick M.; Cole, Kathryn E.; Dowling, Daniel P. Current Opinion in Structural Biology, Vol. 21, Issue 6 https://doi.org/10.1016/j.sbi.2011.08.004	journal	December 2011
Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain Tong, J. J. Nucleic Acids Research, Vol. 30, Issue 5 https://doi.org/10.1093/nar/30.5.1114	journal	March 2002
Properties of an acetylspermidine deacetylase from rat liver Libby, Paul R. Archives of Biochemistry and Biophysics, Vol. 188, Issue 2 https://doi.org/10.1016/S0003-9861(78)80020-4	journal	June 1978
Deacetylation of N8-acetylspermidine by subcellular fractions of rat tissue Blankenship, Jim Archives of Biochemistry and Biophysics, Vol. 189, Issue 1 https://doi.org/10.1016/0003-9861(78)90109-1	journal	July 1978
Rat liver nuclear N-acetyltransferases: Separation of two enzymes with both histone and spermidine acetyltransferase activity Libby, Paul R. Archives of Biochemistry and Biophysics, Vol. 203, Issue 1 https://doi.org/10.1016/0003-9861(80)90190-3	journal	August 1980
A selective inhibitor of N8-acetylspermidine deacetylation in mice and hela cells without effects on histone deacetylation Marchant, Pamela; Dredar, Sasi; Manneh, Victor Archives of Biochemistry and Biophysics, Vol. 273, Issue 1 https://doi.org/10.1016/0003-9861(89)90170-7	journal	August 1989
Histone deacetylase 10 promotes autophagy-mediated cell survival Oehme, I.; Linke, J. -P.; Bock, B. C. Proceedings of the National Academy of Sciences, Vol. 110, Issue 28 https://doi.org/10.1073/pnas.1300113110	journal	June 2013
Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated Géraldy, Magalie; Morgen, Michael; Sehr, Peter Journal of Medicinal Chemistry, Vol. 62, Issue 9 https://doi.org/10.1021/acs.jmedchem.8b01936	journal	April 2019
Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance Ridinger, Johannes; Koeneke, Emily; Kolbinger, Fiona R. Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-28265-5	journal	July 2018
Induction of autophagy by spermidine promotes longevity Eisenberg, Tobias; Knauer, Heide; Schauer, Alexandra Nature Cell Biology, Vol. 11, Issue 11 https://doi.org/10.1038/ncb1975	journal	October 2009
Molecular Basis of the Anti-Aging' Effect of Spermidine and Other Natural Polyamines - A Mini-Review Minois, Nadège Gerontology, Vol. 60, Issue 4 https://doi.org/10.1159/000356748	journal	January 2014
Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A Butler, Kyle V.; Kalin, Jay; Brochier, Camille Journal of the American Chemical Society, Vol. 132, Issue 31 https://doi.org/10.1021/ja102758v	journal	August 2010
Thermal Denaturation Assays in Chemical Biology Senisterra, Guillermo; Chau, Irene; Vedadi, Masoud ASSAY and Drug Development Technologies, Vol. 10, Issue 2 https://doi.org/10.1089/adt.2011.0390	journal	April 2012
Binding of N ⁸ -Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation Herbst-Gervasoni, Corey J.; Christianson, David W. Biochemistry, Vol. 58, Issue 49 https://doi.org/10.1021/acs.biochem.9b00906	journal	November 2019
Histone deacetylase 6 structure and molecular basis of catalysis and inhibition Hai, Yang; Christianson, David W. Nature Chemical Biology, Vol. 12, Issue 9 https://doi.org/10.1038/nchembio.2134	journal	July 2016
Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors Porter, Nicholas J.; Mahendran, Adaickapillai; Breslow, Ronald Proceedings of the National Academy of Sciences, Vol. 114, Issue 51 https://doi.org/10.1073/pnas.1718823114	journal	December 2017
Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6 Porter, Nicholas J.; Wagner, Florence F.; Christianson, David W. Biochemistry, Vol. 57, Issue 26 https://doi.org/10.1021/acs.biochem.8b00367	journal	May 2018
Multicomponent Synthesis and Binding Mode of Imidazo[1,2- a ]pyridine-Capped Selective HDAC6 Inhibitors Mackwitz, Marcel K. W.; Hamacher, Alexandra; Osko, Jeremy D. Organic Letters, Vol. 20, Issue 11 https://doi.org/10.1021/acs.orglett.8b01118	journal	May 2018
Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor Shen, Sida; Svoboda, Michal; Zhang, Guangming ACS Medicinal Chemistry Letters, Vol. 11, Issue 5 https://doi.org/10.1021/acsmedchemlett.9b00560	journal	January 2020
Conformational analysis. 39. Carbon-13 NMR spectra of saturated heterocycles. 9. Piperidine and N-methylpiperidine Eliel, Ernest L.; Kandasamy, Duraisamy; Yen, Chen-yu Journal of the American Chemical Society, Vol. 102, Issue 11 https://doi.org/10.1021/ja00531a006	journal	May 1980
Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors Morgen, Michael; Steimbach, Raphael R.; Géraldy, Magalie ChemMedChem, Vol. 15, Issue 13 https://doi.org/10.1002/cmdc.202000149	journal	May 2020
Structure and Function of the Acetylpolyamine Amidohydrolase from the Deep Earth Halophile Marinobacter subterrani Osko, Jeremy D.; Roose, Benjamin W.; Shinsky, Stephen A. Biochemistry, Vol. 58, Issue 36 https://doi.org/10.1021/acs.biochem.9b00582	journal	August 2019

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