Hsp104: A Weapon to Combat Diverse Neurodegenerative Disorders
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December 2007 |
Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease
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February 2017 |
Engineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced Activity
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March 2016 |
Engineering therapeutic protein disaggregases
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May 2016 |
Designer protein disaggregases to counter neurodegenerative disease
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June 2017 |
AAA+ Protein-Based Technologies to Counter Neurodegenerative Disease
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April 2019 |
Therapeutic Dissolution of Aberrant Phases by Nuclear-Import Receptors
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April 2019 |
Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains
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April 2018 |
Spiraling in Control: Structures and Mechanisms of the Hsp104 Disaggregase
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February 2019 |
Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104
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May 2016 |
Reversible, Specific, Active Aggregates of Endogenous Proteins Assemble upon Heat Stress
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September 2015 |
Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules
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August 2015 |
Different Material States of Pub1 Condensates Define Distinct Modes of Stress Adaptation and Recovery
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June 2018 |
Blessings in disguise: biological benefits of prion-like mechanisms
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June 2013 |
The elusive middle domain of Hsp104 and ClpB: Location and function
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January 2012 |
Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104
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June 2017 |
Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation
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August 2016 |
Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events
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March 2019 |
The Hsp104 N-Terminal Domain Enables Disaggregase Plasticity and Potentiation
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March 2015 |
Operational Plasticity Enables Hsp104 to Disaggregate Diverse Amyloid and Nonamyloid Clients
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November 2012 |
Protein disaggregation mediated by heat-shock protein Hspl04
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December 1994 |
Hsp104, Hsp70, and Hsp40
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July 1998 |
Hsp104 Catalyzes Formation and Elimination of Self-Replicating Sup35 Prion Conformers
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June 2004 |
Destruction or Potentiation of Different Prions Catalyzed by Similar Hsp104 Remodeling Activities
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August 2006 |
Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity
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January 2007 |
Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions
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October 2008 |
The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System
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October 2011 |
Hsp104 and Potentiated Variants Can Operate as Distinct Nonprocessive Translocases
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May 2019 |
Avidity for Polypeptide Binding by Nucleotide-Bound Hsp104 Structures
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April 2017 |
Hydrogen exchange reveals Hsp104 architecture, structural dynamics, and energetics in physiological solution
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March 2019 |
Radiolytic Protein Footprinting with mass Spectrometry to Probe the Structure of Macromolecular Complexes
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June 2006 |
Hydroxyl radical probe of protein surfaces using synchrotron X-ray radiolysis and mass spectrometry
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January 2002 |
Hydroxyl radical probe of the surface of lysozyme by synchrotron radiolysis and mass spectrometry
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January 2001 |
Conserved Distal Loop Residues in the Hsp104 and ClpB Middle Domain Contact Nucleotide-binding Domain 2 and Enable Hsp70-dependent Protein Disaggregation
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January 2014 |
RNA Folding at Millisecond Intervals by Synchrotron Hydroxyl Radical Footprinting
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March 1998 |
Development of Synchrotron Footprinting at NSLS and NSLS-II
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February 2019 |
The Structure of ClpB
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October 2003 |
Crystal structures of Hsp104 N-terminal domains from Saccharomyces cerevisiae and Candida albicans suggest the mechanism for the function of Hsp104 in dissolving prions
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March 2017 |
Crystallographic investigation of peptide binding sites in the N-domain of the ClpA chaperone
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April 2004 |
Crystal Structure of the E. coli Hsp100 ClpB N-Terminal Domain
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March 2003 |
Structure and mechanism of the hexameric MecA–ClpC molecular machine
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March 2011 |
ClpS, a Substrate Modulator of the ClpAP Machine
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March 2002 |
Species-specific collaboration of heat shock proteins (Hsp) 70 and 100 in thermotolerance and protein disaggregation
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April 2011 |
The M-Domain Controls Hsp104 Protein Remodeling Activity in an Hsp70/Hsp40-Dependent Manner
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September 2010 |
M Domains Couple the ClpB Threading Motor with the DnaK Chaperone Activity
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January 2007 |
Hsp70 proteins bind Hsp100 regulatory M domains to activate AAA+ disaggregase at aggregate surfaces
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November 2012 |
Heat shock protein (Hsp) 70 is an activator of the Hsp104 motor
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May 2013 |
CryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation
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April 2010 |
Mechanistic Insights into Hsp104 Potentiation
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March 2016 |
N-Terminal Domain of Yeast Hsp104 Chaperone Is Dispensable for Thermotolerance and Prion Propagation but Necessary for Curing Prions by Hsp104 Overexpression
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April 2006 |
Potentiated Hsp104 Variants Antagonize Diverse Proteotoxic Misfolding Events
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journal
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January 2014 |
Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain
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journal
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April 2018 |
Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity
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journal
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August 2019 |
Engineering enhanced protein disaggregases for neurodegenerative disease
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March 2015 |
Disparate Mutations Confer Therapeutic Gain of Hsp104 Function
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October 2015 |
Cooperative kinetics of both Hsp104 ATPase domains and interdomain communication revealed by AAA sensor-1 mutants
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January 2002 |
Saccharomyces cerevisiae Hsp104 protein. Purification and characterization of ATP-induced structural changes.
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journal
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February 1994 |
Hspl04 is a highly conserved protein with two essential nucleotide-binding sites
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September 1991 |
Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+]
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May 1995 |
Analysis of the AAA sensor-2 motif in the C-terminal ATPase domain of Hsp104 with a site-specific fluorescent probe of nucleotide binding
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journal
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February 2002 |
Evidence for an Unfolding/Threading Mechanism for Protein Disaggregation by Saccharomyces cerevisiae Hsp104
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May 2004 |
Peptide and Protein Binding in the Axial Channel of Hsp104: INSIGHTS INTO THE MECHANISM OF PROTEIN UNFOLDING
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August 2008 |
Substrate Binding to the Molecular Chaperone Hsp104 and Its Regulation by Nucleotides
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journal
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November 2005 |
Loops in the Central Channel of ClpA Chaperone Mediate Protein Binding, Unfolding, and Translocation
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journal
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July 2005 |
Stability of the two wings of the coiled-coil domain of ClpB chaperone is critical for its disaggregation activity
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June 2009 |
ATP Binding to Nucleotide Binding Domain (NBD)1 of the ClpB Chaperone Induces Motion of the Long Coiled-coil, Stabilizes the Hexamer, and Activates NBD2
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July 2005 |
Dominant Gain-of-Function Mutations in Hsp104p Reveal Crucial Roles for the Middle Region
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May 2004 |
Atypical AAA+ Subunit Packing Creates an Expanded Cavity for Disaggregation by the Protein-Remodeling Factor Hsp104
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December 2007 |
Roles of Individual Domains and Conserved Motifs of the AAA+ Chaperone ClpB in Oligomerization, ATP Hydrolysis, and Chaperone Activity
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March 2003 |
Regulation of the Hsp104 Middle Domain Activity Is Critical for Yeast Prion Propagation
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January 2014 |
A tightly regulated molecular toggle controls AAA+ disaggregase
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November 2012 |
Defining a Pathway of Communication from the C-Terminal Peptide Binding Domain to the N-Terminal ATPase Domain in a AAA Protein
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journal
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April 2002 |
Disruption of Ionic Interactions between the Nucleotide Binding Domain 1 (NBD1) and Middle (M) Domain in Hsp100 Disaggregase Unleashes Toxic Hyperactivity and Partial Independence from Hsp70
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journal
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January 2013 |
Channel mutations in Hsp104 hexamer distinctively affect thermotolerance and prion-specific propagation: Prion-specific activity of Hsp104
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March 2007 |
A Systematic Evaluation of the Function of the Protein-Remodeling Factor Hsp104 in [ PSI + ] Prion Propagation in S. cerevisiae by Comprehensive Chromosomal Mutations
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journal
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January 2007 |
Nucleocytoplasmic Trafficking of the Molecular Chaperone Hsp104 in Unstressed and Heat-Shocked Cells
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journal
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January 2008 |
Evolutionary Relationships and Structural Mechanisms of aaa+ Proteins
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June 2006 |
Amino Acid Substitutions in the C-terminal AAA + Module of Hsp104 Prevent Substrate Recognition by Disrupting Oligomerization and Cause High Temperature Inactivation
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June 2004 |
The ATPase Activity of Hsp104, Effects of Environmental Conditions and Mutations
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June 1998 |
Structural basis for intersubunit signaling in a protein disaggregating machine
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July 2012 |
HSP104 required for induced thermotolerance
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June 1990 |
Protein Modeling by E-mail
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July 1995 |
High-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method
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January 2007 |
The Beamline X28C of the Center for Synchrotron Biosciences: a National Resource for Biomolecular Structure and Dynamics Experiments Using Synchrotron Footprinting
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journal
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April 2007 |
Synchrotron Protein Footprinting Supports Substrate Translocation by ClpA via ATP-Induced Movements of the D2 Loop
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journal
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August 2008 |
ExMS: Data Analysis for HX-MS Experiments
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journal
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September 2011 |
Integrated Algorithms for High-Throughput Examination of Covalently Labeled Biomolecules by Structural Mass Spectrometry
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journal
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October 2009 |
The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling
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journal
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November 2005 |
The SWISS-MODEL Repository and associated resources
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January 2009 |