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Title: Unique roles of iron and zinc binding to the yeast Fe-S cluster scaffold assembly protein "Isu1"

Journal Article · · Metallomics
DOI:https://doi.org/10.1039/C9MT00172G· OSTI ID:1689915
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Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Organization:
~OTHER
DOE Contract Number:
SC0012704
OSTI ID:
1689915
Report Number(s):
BNL-220244-2020-JACI
Journal Information:
Metallomics, Vol. 11
Country of Publication:
United States
Language:
English

References (61)

New Perspectives on Iron Uptake in Eukaryotes journal November 2018
Special issue on iron–sulfur proteins: Structure, function, biogenesis and diseases journal June 2015
Iron–sulfur cluster biosynthesis and trafficking – impact on human disease conditions journal January 2018
Synthesis, delivery and regulation of eukaryotic heme and Fe–S cluster cofactors journal February 2016
Iron–sulfur cluster biogenesis and trafficking in mitochondria journal June 2017
An interaction between frataxin and Isu1/Nfs1 that is crucial for Fe/S cluster synthesis on Isu1 journal August 2003
The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis journal August 2016
Essential role of Isd11 in mitochondrial iron–sulfur cluster synthesis on Isu scaffold proteins journal December 2005
The Nfs1 interacting protein Isd11 has an essential role in Fe/S cluster biogenesis in mitochondria journal December 2005
Structure of human Fe–S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP–ISD11 interactions journal June 2017
Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis journal June 2010
Regulation of Mitochondrial Iron Accumulation by Yfh1p, a Putative Homolog of Frataxin journal June 1997
Mitochondrial functional interactions between frataxin and Isu1p, the iron-sulfur cluster scaffold protein, in Saccharomyces cerevisiae journal December 2003
Molecular Details of the Yeast Frataxin−Isu1 Interaction during Mitochondrial Fe−S Cluster Assembly journal October 2010
Acidic residues of yeast frataxin have an essential role in Fe–S cluster assembly journal December 2006
Iron Binding and Oxidation Kinetics in Frataxin CyaY of Escherichia coli journal August 2004
Yeast Frataxin Solution Structure, Iron Binding, and Ferrochelatase Interaction † , ‡ journal December 2004
Human Frataxin Activates Fe–S Cluster Biosynthesis by Facilitating Sulfur Transfer Chemistry journal July 2014
Bacterial frataxin CyaY is the gatekeeper of iron-sulfur cluster formation catalyzed by IscS journal March 2009
Structure and Dynamics of the Iron−Sulfur Cluster Assembly Scaffold Protein IscU and Its Interaction with the Cochaperone HscB journal July 2009
Metamorphic protein IscU alternates conformations in the course of its role as the scaffold protein for iron-sulfur cluster biosynthesis and delivery journal January 2013
Iron−Sulfur Cluster Biosynthesis:  Toward an Understanding of Cellular Machinery and Molecular Mechanism † journal September 2004
Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex journal November 2017
Iron loading site on the Fe–S cluster assembly scaffold protein is distinct from the active site journal March 2015
Iron−Sulfur Cluster Biosynthesis:  Characterization of Iron Nucleation Sites for Assembly of the [2Fe−2S] 2+ Cluster Core in IscU Proteins journal July 2002
ISCU(M108I) and ISCU(D39V) Differ from Wild-Type ISCU in Their Failure To Form Cysteine Desulfurase Complexes Containing Both Frataxin and Ferredoxin journal February 2018
Detection of Labile Low-Molecular-Mass Transition Metal Complexes in Mitochondria journal May 2015
Recovery of mrs3Δmrs4Δ Saccharomyces cerevisiae Cells under Iron-Sufficient Conditions and the Role of Fe 580 journal January 2018
A Nonheme High-Spin Ferrous Pool in Mitochondria Isolated from Fermenting Saccharomyces cerevisiae journal May 2010
The role of zinc in the stability of the marginally stable IscU scaffold protein: The Stability Determinants of IscU journal July 2014
Structural characterization of an iron-sulfur cluster assembly protein IscU in a zinc-bound form journal April 2005
Solution NMR Structure of the Iron–Sulfur Cluster Assembly Protein U (IscU) with Zinc Bound at the Active Site journal November 2004
Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity journal September 2018
Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism journal May 2019
A Mutant Human IscU Protein Contains a Stable [2Fe−2S]2+ Center of Possible Functional Significance journal June 2000
Mapping iron binding sites on human frataxin: implications for cluster assembly on the ISU Fe–S cluster scaffold protein journal April 2008
Program DYNAFIT for the Analysis of Enzyme Kinetic Data: Application to HIV Proteinase journal June 1996
Progress and challenges in the theory and interpretation of X-ray spectra journal March 2001
Analysis of Sulfur Biochemistry of Sulfur Bacteria Using X-ray Absorption Spectroscopy † journal July 2001
Monomeric Yeast Frataxin Is an Iron-Binding Protein † journal June 2006
A new metal binding domain involved in cadmium, cobalt and zinc transport journal July 2015
Clustal Omega for making accurate alignments of many protein sequences: Clustal Omega for Many Protein Sequences journal October 2017
I-TASSER: a unified platform for automated protein structure and function prediction journal March 2010
Protein Structure and Function Prediction Using I‐TASSER journal December 2015
Zinc Distribution and Expression Pattern of ZnT3 in Mouse Brain journal June 2007
Comparison of the Response of Bacterial IscU and SufU to Zn 2+ and Select Transition-Metal Ions journal December 2017
Iron–sulfur cluster biosynthesis journal November 2008
X-ray Absorption Pre-Edge Studies of High-spin Iron(II) Complexes journal March 1995
Structure and Ubiquitin Interactions of the Conserved Zinc Finger Domain of Npl4 journal March 2003
Characterization and Structure of a Zn 2+ and [2Fe-2S]-containing Copper Chaperone from Archaeoglobus fulgidus journal July 2007
The Cambridge Structural Database
  • Groom, Colin R.; Bruno, Ian J.; Lightfoot, Matthew P.
  • Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials, Vol. 72, Issue 2, p. 171-179 https://doi.org/10.1107/S2052520616003954
journal April 2016
The Human Iron–Sulfur Assembly Complex Catalyzes the Synthesis of [2Fe-2S] Clusters on ISCU2 That Can Be Transferred to Acceptor Molecules journal June 2015
Turning Saccharomyces cerevisiae into a Frataxin-Independent Organism journal May 2015
The Asymmetric Trimeric Architecture of [2Fe–2S] IscU: Implications for Its Scaffolding during Iron–Sulfur Cluster Biosynthesis journal October 2008
Mammalian Frataxin: An Essential Function for Cellular Viability through an Interaction with a Preformed ISCU/NFS1/ISD11 Iron-Sulfur Assembly Complex journal January 2011
Human Frataxin Is an Allosteric Switch That Activates the Fe−S Cluster Biosynthetic Complex journal November 2010
Three-Dimensional Structure and Determinants of Stability of the Iron–Sulfur Cluster Scaffold Protein IscU from Escherichia coli journal July 2012
The Scaffold Protein IscU Retains a Structured Conformation in the FeS Cluster Assembly Complex journal July 2014
Order of Stability of Metal Complexes journal November 1948
Cleavage and polyadenylation specificity factor 30: An RNA-binding zinc-finger protein with an unexpected 2Fe–2S cluster journal April 2016
Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin journal August 2019

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