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Title: A reverse 230U/226Th radionuclide generator for targeted alpha therapy applications

Abstract

Thorium-226 (half-life 30.6 m) is a radionuclide of interest for use in targeted alpha therapy applications. Additionally, due to its short half-life, 226Th must be provided through a radionuclide generator system from its parent 230U (20.8 d). Furthermore, as the half-life of 226Th is very short, it should be provided in a form that is directly amenable to use in biomedical applications.

Authors:
 [1]; ORCiD logo [2];  [3];  [2];  [4]; ORCiD logo [2]; ORCiD logo [2]; ORCiD logo [2]; ORCiD logo [2]
  1. Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Univ. of Utah, Salt Lake City, UT (United States)
  2. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  3. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  4. Univ. of Washington, Seattle, WA (United States)
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1671108
Alternate Identifier(s):
OSTI ID: 1778557
Report Number(s):
LA-UR-20-25550
Journal ID: ISSN 0969-8051
Grant/Contract Number:  
89233218CNA000001; LAB 14-1099
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Nuclear Medicine and Biology
Additional Journal Information:
Journal Volume: 90-91; Journal ID: ISSN 0969-8051
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; Targeted alpha therpy; 226-Th; 230-U/226-Th radionuclide generator

Citation Formats

Mastren, Tara, Akin, Andrew, Copping, Roy, Brugh, Mark, Wilbur, D. Scott, Birnbaum, Eva R., Nortier, Francois M., John, Kevin D., and Fassbender, Michael E. A reverse 230U/226Th radionuclide generator for targeted alpha therapy applications. United States: N. p., 2020. Web. doi:10.1016/j.nucmedbio.2020.09.006.
Mastren, Tara, Akin, Andrew, Copping, Roy, Brugh, Mark, Wilbur, D. Scott, Birnbaum, Eva R., Nortier, Francois M., John, Kevin D., & Fassbender, Michael E. A reverse 230U/226Th radionuclide generator for targeted alpha therapy applications. United States. https://doi.org/10.1016/j.nucmedbio.2020.09.006
Mastren, Tara, Akin, Andrew, Copping, Roy, Brugh, Mark, Wilbur, D. Scott, Birnbaum, Eva R., Nortier, Francois M., John, Kevin D., and Fassbender, Michael E. 2020. "A reverse 230U/226Th radionuclide generator for targeted alpha therapy applications". United States. https://doi.org/10.1016/j.nucmedbio.2020.09.006. https://www.osti.gov/servlets/purl/1671108.
@article{osti_1671108,
title = {A reverse 230U/226Th radionuclide generator for targeted alpha therapy applications},
author = {Mastren, Tara and Akin, Andrew and Copping, Roy and Brugh, Mark and Wilbur, D. Scott and Birnbaum, Eva R. and Nortier, Francois M. and John, Kevin D. and Fassbender, Michael E.},
abstractNote = {Thorium-226 (half-life 30.6 m) is a radionuclide of interest for use in targeted alpha therapy applications. Additionally, due to its short half-life, 226Th must be provided through a radionuclide generator system from its parent 230U (20.8 d). Furthermore, as the half-life of 226Th is very short, it should be provided in a form that is directly amenable to use in biomedical applications.},
doi = {10.1016/j.nucmedbio.2020.09.006},
url = {https://www.osti.gov/biblio/1671108}, journal = {Nuclear Medicine and Biology},
issn = {0969-8051},
number = ,
volume = 90-91,
place = {United States},
year = {2020},
month = {9}
}

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