A reverse 230U/226Th radionuclide generator for targeted alpha therapy applications

Mastren, Tara; Akin, Andrew; Copping, Roy; Brugh, Mark; Wilbur, D. Scott; Birnbaum, Eva R.; Nortier, Francois M.; John, Kevin D.; Fassbender, Michael E.

doi:10.1016/j.nucmedbio.2020.09.006

Title: A reverse ²³⁰U/²²⁶Th radionuclide generator for targeted alpha therapy applications

Abstract

Thorium-226 (half-life 30.6 m) is a radionuclide of interest for use in targeted alpha therapy applications. Additionally, due to its short half-life, ²²⁶Th must be provided through a radionuclide generator system from its parent ²³⁰U (20.8 d). Furthermore, as the half-life of ²²⁶Th is very short, it should be provided in a form that is directly amenable to use in biomedical applications.

Authors:

Mastren, Tara ^[1];

^[2]; Copping, Roy ^[3]; Brugh, Mark ^[2]; Wilbur, D. Scott ^[4];

^[2];

^[2]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Univ. of Utah, Salt Lake City, UT (United States)
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Univ. of Washington, Seattle, WA (United States)

Publication Date:: 2020-09-30

Research Org.:: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Sponsoring Org.:: USDOE Office of Science (SC)

OSTI Identifier:: 1671108

Alternate Identifier(s):: OSTI ID: 1778557

Report Number(s):: LA-UR-20-25550
Journal ID: ISSN 0969-8051; TRN: US2203891

Grant/Contract Number:: 89233218CNA000001; LAB 14-1099

Resource Type:: Journal Article: Accepted Manuscript

Journal Name:: Nuclear Medicine and Biology

Additional Journal Information:: Journal Volume: 90-91; Journal ID: ISSN 0969-8051

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; Targeted alpha therpy; 226-Th; 230-U/226-Th radionuclide generator

Citation Formats


                    Mastren, Tara, Akin, Andrew, Copping, Roy, Brugh, Mark, Wilbur, D. Scott, Birnbaum, Eva R., Nortier, Francois M., John, Kevin D., and Fassbender, Michael E.. A reverse 230U/226Th radionuclide generator for targeted alpha therapy applications.  United States: N. p., 2020. 
        Web.  doi:10.1016/j.nucmedbio.2020.09.006.

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                    Mastren, Tara, Akin, Andrew, Copping, Roy, Brugh, Mark, Wilbur, D. Scott, Birnbaum, Eva R., Nortier, Francois M., John, Kevin D., & Fassbender, Michael E.. A reverse 230U/226Th radionuclide generator for targeted alpha therapy applications.  United States.  https://doi.org/10.1016/j.nucmedbio.2020.09.006

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                    Mastren, Tara, Akin, Andrew, Copping, Roy, Brugh, Mark, Wilbur, D. Scott, Birnbaum, Eva R., Nortier, Francois M., John, Kevin D., and Fassbender, Michael E.. 2020.  
        "A reverse 230U/226Th radionuclide generator for targeted alpha therapy applications".  United States.  https://doi.org/10.1016/j.nucmedbio.2020.09.006.  https://www.osti.gov/servlets/purl/1671108.

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@article{osti_1671108,

  title        = {A reverse 230U/226Th radionuclide generator for targeted alpha therapy applications},

  author       = {Mastren, Tara and Akin, Andrew and Copping, Roy and Brugh, Mark and Wilbur, D. Scott and Birnbaum, Eva R. and Nortier, Francois M. and John, Kevin D. and Fassbender, Michael E.},

  abstractNote = {Thorium-226 (half-life 30.6 m) is a radionuclide of interest for use in targeted alpha therapy applications. Additionally, due to its short half-life, 226Th must be provided through a radionuclide generator system from its parent 230U (20.8 d). Furthermore, as the half-life of 226Th is very short, it should be provided in a form that is directly amenable to use in biomedical applications.},

  doi          = {10.1016/j.nucmedbio.2020.09.006},

  url          = {https://www.osti.gov/biblio/1671108},
  journal      = {Nuclear Medicine and Biology},

  issn         = {0969-8051},

  number       = ,

  volume       = 90-91,

  place        = {United States},

  year         = {2020},

  month        = {9}

}

Copy to clipboard

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Title: A reverse 230U/226Th radionuclide generator for targeted alpha therapy applications

Abstract

Citation Formats

Production of 230Pa from Proton-irradiated Thorium and Developing 230Pa/230U/226Th Tandem Generator journal, December 2019

Separation of Protactinium Employing Sulfur-Based Extraction Chromatographic Resins journal, April 2018

Separation Studies of Uranium and Thorium Using Di-2-Ethylhexyl Isobutyramide (D2EHIBA) journal, September 1999

Anion exchange separation of uranium, thorium and bismuth journal, January 1962

Separation of Th, U, Pa, Ra and Ac from natural uranium and thorium series journal, November 1999

Production of 230 U/ 226 Th for Targeted Alpha Therapy via Proton Irradiation of 231 Pa journal, November 2008

Formation cross-sections and chromatographic separation of protactinium isotopes formed in proton-irradiated thorium metal journal, January 2016

The mutual separation of thorium, protoactinium, and uranium by tributyl phosphate extraction from hydrochloric acid journal, January 1957

Advancements in cancer therapy with alpha-emitters: a review journal, September 2001

Sequential separation of lanthanides, thorium and uranium using novel solid phase extraction method from high acidic nuclear wastes journal, June 2007

Thorium chelators for targeted alpha therapy: Rapid chelation of thorium-226 journal, September 2020

An overview of targeted alpha therapy journal, December 2011

Application of ion-exchange separations to determination of trace elements in natural waters—IX Simultaneous isolation and determination of uranium and thorium journal, April 1976

Separation studies of uranium and thorium using tetra(2-ethylhexyl) diglycolamide (TEHDGA) as an extractant journal, June 2008

Distribution coefficients of 60 elements on TODGA resin: Application to Ca, Lu, Hf, U and Th isotope geochemistry journal, May 2010

Use of o-phenylene dioxydiacetic acid impregnated in Amberlite XAD resin for separation and preconcentration of uranium(VI) and thorium(IV) journal, March 2008

In Vitro Cytotoxicity of Low-Dose-Rate Radioimmunotherapy by the Alpha-Emitting Radioimmunoconjugate Thorium-227–DOTA–Rituximab journal, November 2009

An efficient chelator for complexation of thorium-227 journal, September 2016

Separation of uranium(VI) as chloride complex by solvent extraction with dicyclohexyl-18-crown-6 journal, April 1989

A Macrocyclic Chelator with Unprecedented Th 4+ Affinity journal, June 2014

Determination of uranium and thorium in geological materials using extraction chromatography journal, January 1999

Separation of thorium and uranium nitrates by anion exchange journal, January 1957

Production of Alpha Emitters for Targeted Alpha Therapy journal, September 2008

Kinetically and thermodynamically stable isomers of thorium chelates of polyaza polycarboxylic macrocycles journal, October 1994

Initial evaluation of 227Th-p-benzyl-DOTA-rituximab for low-dose rate α-particle radioimmunotherapy journal, February 2006

Production of 230Pa by proton irradiation of 232Th at the LANL isotope production facility: Precursor of 230U for targeted alpha therapy journal, February 2020

Separation of Thorium and Uranium from Silicate Rock Samples Using Two Commercial Extraction Chromatographic Resins journal, January 1999

Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes journal, February 2015

Title: A reverse ²³⁰U/²²⁶Th radionuclide generator for targeted alpha therapy applications

Production of 230Pa from Proton-irradiated Thorium and Developing 230Pa/230U/226Th Tandem Generator
journal, December 2019

Separation of Protactinium Employing Sulfur-Based Extraction Chromatographic Resins
journal, April 2018

Separation Studies of Uranium and Thorium Using Di-2-Ethylhexyl Isobutyramide (D2EHIBA)
journal, September 1999

Anion exchange separation of uranium, thorium and bismuth
journal, January 1962

Separation of Th, U, Pa, Ra and Ac from natural uranium and thorium series
journal, November 1999

Production of ²³⁰ U/ ²²⁶ Th for Targeted Alpha Therapy via Proton Irradiation of ²³¹ Pa
journal, November 2008

Formation cross-sections and chromatographic separation of protactinium isotopes formed in proton-irradiated thorium metal
journal, January 2016

The mutual separation of thorium, protoactinium, and uranium by tributyl phosphate extraction from hydrochloric acid
journal, January 1957

Advancements in cancer therapy with alpha-emitters: a review
journal, September 2001

Sequential separation of lanthanides, thorium and uranium using novel solid phase extraction method from high acidic nuclear wastes
journal, June 2007

Thorium chelators for targeted alpha therapy: Rapid chelation of thorium-226
journal, September 2020

An overview of targeted alpha therapy
journal, December 2011

Application of ion-exchange separations to determination of trace elements in natural waters—IX Simultaneous isolation and determination of uranium and thorium
journal, April 1976

Separation studies of uranium and thorium using tetra(2-ethylhexyl) diglycolamide (TEHDGA) as an extractant
journal, June 2008

Distribution coefficients of 60 elements on TODGA resin: Application to Ca, Lu, Hf, U and Th isotope geochemistry
journal, May 2010

Use of o-phenylene dioxydiacetic acid impregnated in Amberlite XAD resin for separation and preconcentration of uranium(VI) and thorium(IV)
journal, March 2008

In Vitro Cytotoxicity of Low-Dose-Rate Radioimmunotherapy by the Alpha-Emitting Radioimmunoconjugate Thorium-227–DOTA–Rituximab
journal, November 2009

An efficient chelator for complexation of thorium-227
journal, September 2016

Separation of uranium(VI) as chloride complex by solvent extraction with dicyclohexyl-18-crown-6
journal, April 1989

A Macrocyclic Chelator with Unprecedented Th ⁴⁺ Affinity
journal, June 2014

Determination of uranium and thorium in geological materials using extraction chromatography
journal, January 1999

Separation of thorium and uranium nitrates by anion exchange
journal, January 1957

Production of Alpha Emitters for Targeted Alpha Therapy
journal, September 2008

Kinetically and thermodynamically stable isomers of thorium chelates of polyaza polycarboxylic macrocycles
journal, October 1994

Initial evaluation of 227Th-p-benzyl-DOTA-rituximab for low-dose rate α-particle radioimmunotherapy
journal, February 2006

Production of 230Pa by proton irradiation of 232Th at the LANL isotope production facility: Precursor of 230U for targeted alpha therapy
journal, February 2020

Separation of Thorium and Uranium from Silicate Rock Samples Using Two Commercial Extraction Chromatographic Resins
journal, January 1999

Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes
journal, February 2015