skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Hybrid nanocapsules for in situ TEM imaging of gas evolution reactions in confined liquids.

Abstract

Gold-coated liposome nanocapsules enable in situ TEM imaging and mixing of nanoscale reactions confined in zeptoliter volumes.

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22), Scientific User Facilities Division (SC-22.3 ); USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI Identifier:
1670136
Alternate Identifier(s):
OSTI ID: 1657632
Grant/Contract Number:  
AC02-05CH11231
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Nanoscale
Additional Journal Information:
Journal Volume: 12; Journal Issue: 36
Country of Publication:
United States
Language:
English

Citation Formats

Alam, Sardar B, Yang, Jiwoong, Bustillo, Karen C, Ophus, Colin, Ercius, Peter, Zheng, Haimei, and Chan, Emory M. Hybrid nanocapsules for in situ TEM imaging of gas evolution reactions in confined liquids.. United States: N. p., 2020. Web. doi:10.1039/d0nr05281g.
Alam, Sardar B, Yang, Jiwoong, Bustillo, Karen C, Ophus, Colin, Ercius, Peter, Zheng, Haimei, & Chan, Emory M. Hybrid nanocapsules for in situ TEM imaging of gas evolution reactions in confined liquids.. United States. doi:10.1039/d0nr05281g.
Alam, Sardar B, Yang, Jiwoong, Bustillo, Karen C, Ophus, Colin, Ercius, Peter, Zheng, Haimei, and Chan, Emory M. Thu . "Hybrid nanocapsules for in situ TEM imaging of gas evolution reactions in confined liquids.". United States. doi:10.1039/d0nr05281g.
@article{osti_1670136,
title = {Hybrid nanocapsules for in situ TEM imaging of gas evolution reactions in confined liquids.},
author = {Alam, Sardar B and Yang, Jiwoong and Bustillo, Karen C and Ophus, Colin and Ercius, Peter and Zheng, Haimei and Chan, Emory M},
abstractNote = {Gold-coated liposome nanocapsules enable in situ TEM imaging and mixing of nanoscale reactions confined in zeptoliter volumes.},
doi = {10.1039/d0nr05281g},
journal = {Nanoscale},
number = 36,
volume = 12,
place = {United States},
year = {2020},
month = {9}
}

Journal Article:
Free Publicly Available Full Text
This content will become publicly available on September 3, 2021
Publisher's Version of Record

Save / Share:

Works referenced in this record:

Liquid Cell Transmission Electron Microscopy
journal, May 2016


Opportunities and challenges in liquid cell electron microscopy
journal, December 2015


Multistep nucleation of nanocrystals in aqueous solution
journal, October 2016

  • Loh, N. Duane; Sen, Soumyo; Bosman, Michel
  • Nature Chemistry, Vol. 9, Issue 1
  • DOI: 10.1038/nchem.2618

Facet development during platinum nanocube growth
journal, August 2014


Gold Nanocrystal Etching as a Means of Probing the Dynamic Chemical Environment in Graphene Liquid Cell Electron Microscopy
journal, February 2019

  • Hauwiller, Matthew R.; Ondry, Justin C.; Chan, Cindy M.
  • Journal of the American Chemical Society, Vol. 141, Issue 10
  • DOI: 10.1021/jacs.9b00082

Dynamic microscopy of nanoscale cluster growth at the solid–liquid interface
journal, July 2003

  • Williamson, M. J.; Tromp, R. M.; Vereecken, P. M.
  • Nature Materials, Vol. 2, Issue 8
  • DOI: 10.1038/nmat944

Visualization of Electrode–Electrolyte Interfaces in LiPF 6 /EC/DEC Electrolyte for Lithium Ion Batteries via in Situ TEM
journal, March 2014

  • Zeng, Zhiyuan; Liang, Wen-I; Liao, Hong-Gang
  • Nano Letters, Vol. 14, Issue 4
  • DOI: 10.1021/nl403922u

In situ TEM imaging of CaCO3 nucleation reveals coexistence of direct and indirect pathways
journal, September 2014


Nucleation of Iron Oxide Nanoparticles Mediated by Mms6 Protein in Situ
journal, August 2014

  • Kashyap, Sanjay; Woehl, Taylor J.; Liu, Xunpei
  • ACS Nano, Vol. 8, Issue 9
  • DOI: 10.1021/nn502551y

“On demand” triggered crystallization of CaCO 3 from solute precursor species stabilized by the water-in-oil microemulsion
journal, January 2018

  • Stawski, Tomasz M.; Roncal-Herrero, Teresa; Fernandez-Martinez, Alejandro
  • Physical Chemistry Chemical Physics, Vol. 20, Issue 20
  • DOI: 10.1039/C8CP00540K

Off-axis electron holography of bacterial cells and magnetic nanoparticles in liquid
journal, October 2017

  • Prozorov, Tanya; Almeida, Trevor P.; Kovács, András
  • Journal of The Royal Society Interface, Vol. 14, Issue 135
  • DOI: 10.1098/rsif.2017.0464

Visualizing Gold Nanoparticle Uptake in Live Cells with Liquid Scanning Transmission Electron Microscopy
journal, April 2011

  • Peckys, Diana B.; de Jonge, Niels
  • Nano Letters, Vol. 11, Issue 4
  • DOI: 10.1021/nl200285r

High-Resolution EM of Colloidal Nanocrystal Growth Using Graphene Liquid Cells
journal, April 2012


Graphene Liquid Cells Assembled through Loop‐Assisted Transfer Method and Located with Correlated Light‐Electron Microscopy
journal, February 2020

  • Deursen, Pauline M. G.; Koning, Roman I.; Tudor, Viorica
  • Advanced Functional Materials, Vol. 30, Issue 11
  • DOI: 10.1002/adfm.201904468

In-situ liquid cell transmission electron microscopy investigation on oriented attachment of gold nanoparticles
journal, January 2018


Dynamic deformability of individual PbSe nanocrystals during superlattice phase transitions
journal, June 2019


Scrolling graphene into nanofluidic channels
journal, January 2013

  • Mirsaidov, Utkur; Mokkapati, V. R. S. S.; Bhattacharya, Dipanjan
  • Lab on a Chip, Vol. 13, Issue 15, p. 2874-2878
  • DOI: 10.1039/c3lc50304f

In situ chemical experiments in carbon nanotubes
journal, October 2002


Review: static and dynamic behavior of liquids inside carbon nanotubes
journal, April 2008


High-Resolution Imaging and Spectroscopy at High Pressure: A Novel Liquid Cell for the Transmission Electron Microscope
journal, December 2015

  • Tanase, Mihaela; Winterstein, Jonathan; Sharma, Renu
  • Microscopy and Microanalysis, Vol. 21, Issue 6
  • DOI: 10.1017/S1431927615015482

Nanometer Resolution Elemental Mapping in Graphene-Based TEM Liquid Cells
journal, January 2018


Liquid-Phase Electron Microscopy with Controllable Liquid Thickness
journal, June 2019


Extracellular vesicles: Exosomes, microvesicles, and friends
journal, February 2013

  • Raposo, Graça; Stoorvogel, Willem
  • The Journal of Cell Biology, Vol. 200, Issue 4
  • DOI: 10.1083/jcb.201211138

The Mechanisms of Vesicle Budding and Fusion
journal, January 2004


Enzymes inside lipid vesicles: preparation, reactivity and applications
journal, October 2001


Pharmaceutical liposomal drug delivery: a review of new delivery systems and a look at the regulatory landscape
journal, May 2016


Nanoparticle Formation in Giant Vesicles: Synthesis in Biomimetic Compartments
journal, September 2009


Chemical Transformations in Individual Ultrasmall Biomimetic Containers
journal, March 1999


Phospholipid vesicles as a model system for biomineralization
journal, December 1986

  • Mann, Stephen; Hannington, John P.; Williams, R. J. P.
  • Nature, Vol. 324, Issue 6097
  • DOI: 10.1038/324565a0

Integrated Nanoreactor Systems:  Triggering the Release and Mixing of Compounds Inside Single Vesicles
journal, July 2004

  • Bolinger, Pierre-Yves; Stamou, Dimitrios; Vogel, Horst
  • Journal of the American Chemical Society, Vol. 126, Issue 28
  • DOI: 10.1021/ja049023u

A Thermoresponsive Bubble-Generating Liposomal System for Triggering Localized Extracellular Drug Delivery
journal, December 2012

  • Chen, Ko-Jie; Liang, Hsiang-Fa; Chen, Hsin-Lung
  • ACS Nano, Vol. 7, Issue 1
  • DOI: 10.1021/nn304474j

Controllable electrofusion of lipid vesicles: initiation and analysis of reactions within biomimetic containers
journal, January 2014

  • Robinson, T.; Verboket, P. E.; Eyer, K.
  • Lab on a Chip, Vol. 14, Issue 15
  • DOI: 10.1039/c4lc00460d

Vesicle Fusion Triggered by Optically Heated Gold Nanoparticles
journal, May 2015


In-Situ Transmission Electron Microscopy of Liposomes in an Aqueous Environment
journal, July 2013

  • Hoppe, Sarah M.; Sasaki, Darryl Y.; Kinghorn, Aubrianna N.
  • Langmuir, Vol. 29, Issue 32
  • DOI: 10.1021/la401288g

Monitoring the dynamics of cell-derived extracellular vesicles at the nanoscale by liquid-cell transmission electron microscopy
journal, January 2018

  • Piffoux, Max; Ahmad, Nabeel; Nelayah, Jaysen
  • Nanoscale, Vol. 10, Issue 3
  • DOI: 10.1039/C7NR07576F

In Situ Ni 2+ Stain for Liposome Imaging by Liquid-Cell Transmission Electron Microscopy
journal, May 2020


Directly Observing Micelle Fusion and Growth in Solution by Liquid-Cell Transmission Electron Microscopy
journal, November 2017

  • Parent, Lucas R.; Bakalis, Evangelos; Ramírez-Hernández, Abelardo
  • Journal of the American Chemical Society, Vol. 139, Issue 47
  • DOI: 10.1021/jacs.7b09060

Dynamics of amphiphilic block copolymers in an aqueous solution: direct imaging of micelle formation and nanoparticle encapsulation
journal, January 2019

  • Li, Chang; Tho, Che Chen; Galaktionova, Daria
  • Nanoscale, Vol. 11, Issue 5
  • DOI: 10.1039/C8NR08922A

Liquid–liquid phase separation during amphiphilic self-assembly
journal, February 2019


Organization and interaction of cholesterol and phosphatidylcholine in model bilayer membranes
journal, January 1990

  • Hyslop, Paul A.; Morel, Benoit; Sauerheber, Richard D.
  • Biochemistry, Vol. 29, Issue 4
  • DOI: 10.1021/bi00456a027

Deformation of Adsorbed Lipid Vesicles as a Function of Vesicle Size
journal, March 2010


Vesicle adsorption on SiO2 and TiO2: Dependence on vesicle size
journal, October 2002

  • Reimhult, Erik; Höök, Fredrik; Kasemo, Bengt
  • The Journal of Chemical Physics, Vol. 117, Issue 16
  • DOI: 10.1063/1.1515320

Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets
journal, July 2013


Liquid-Cell Electron Tomography of Biological Systems
journal, June 2019


A Technical Introduction to Transmission Electron Microscopy for Soft‐Matter: Imaging, Possibilities, Choices, and Technical Developments
journal, April 2020


Spectrally Tunable Leakage-Free Gold Nanocontainers
journal, December 2009

  • Jin, Yongdong; Gao, Xiaohu
  • Journal of the American Chemical Society, Vol. 131, Issue 49
  • DOI: 10.1021/ja9076765

Biodegradable Plasmon Resonant Nanoshells
journal, July 2008

  • Troutman, Timothy S.; Barton, Jennifer K.; Romanowski, Marek
  • Advanced Materials, Vol. 20, Issue 13
  • DOI: 10.1002/adma.200703026

Bubble and Pattern Formation in Liquid Induced by an Electron Beam
journal, December 2013

  • Grogan, Joseph M.; Schneider, Nicholas M.; Ross, Frances M.
  • Nano Letters, Vol. 14, Issue 1
  • DOI: 10.1021/nl404169a

Spatially dependent dose rate in liquid cell transmission electron microscopy
journal, January 2018

  • Gupta, Tanya; Schneider, Nicholas M.; Park, Jeung Hun
  • Nanoscale, Vol. 10, Issue 16
  • DOI: 10.1039/C8NR01935E

Radiation damage in organic crystalline films
journal, January 1984


Reduction in electron irradiation damage to organic compounds by conducting coatings
journal, July 1974


The Use of Graphene and Its Derivatives for Liquid-Phase Transmission Electron Microscopy of Radiation-Sensitive Specimens
journal, December 2016


Reduced Radiation Damage in Transmission Electron Microscopy of Proteins in Graphene Liquid Cells
journal, November 2018


Electron–Water Interactions and Implications for Liquid Cell Electron Microscopy
journal, September 2014

  • Schneider, Nicholas M.; Norton, Michael M.; Mendel, Brian J.
  • The Journal of Physical Chemistry C, Vol. 118, Issue 38
  • DOI: 10.1021/jp507400n

A History of Nanobubbles
journal, September 2016


A Deliberation on Nanobubbles at Surfaces and in Bulk
journal, February 2012

  • Seddon, James R. T.; Lohse, Detlef; Ducker, William A.
  • ChemPhysChem, Vol. 13, Issue 8
  • DOI: 10.1002/cphc.201100900

Nanobubbles in confined solution: Generation, contact angle, and stability
journal, February 2018

  • Wei, Jiachen; Zhang, Xianren; Song, Fan
  • The Journal of Chemical Physics, Vol. 148, Issue 6
  • DOI: 10.1063/1.5010991

Mixing subattolitre volumes in a quantitative and highly parallel manner with soft matter nanofluidics
journal, October 2011

  • Christensen, Sune M.; Bolinger, Pierre-Yves; Hatzakis, Nikos S.
  • Nature Nanotechnology, Vol. 7, Issue 1
  • DOI: 10.1038/nnano.2011.185

In situ liquid-cell electron microscopy of silver–palladium galvanic replacement reactions on silver nanoparticles
journal, September 2014

  • Sutter, E.; Jungjohann, K.; Bliznakov, S.
  • Nature Communications, Vol. 5, Issue 1
  • DOI: 10.1038/ncomms5946

What is the surface tension of a lipid bilayer membrane?
journal, September 1996


Formation of planar bilayers from artificial or native membrane vesicles
journal, December 1980


Water permeability of polyunsaturated lipid membranes measured by 17O NMR
journal, August 1997


Structural Determinants of Water Permeability through the Lipid Membrane
journal, December 2007

  • Mathai, John C.; Tristram-Nagle, Stephanie; Nagle, John F.
  • The Journal of General Physiology, Vol. 131, Issue 1
  • DOI: 10.1085/jgp.200709848

A high flow rate thermal bubble-driven micropump with induction heating
journal, November 2016

  • Liu, Bendong; Sun, Jianchuang; Li, Desheng
  • Microfluidics and Nanofluidics, Vol. 20, Issue 11
  • DOI: 10.1007/s10404-016-1822-2

On-chip microfluidic transport and bio/chemical sensing based on electrochemical bubble formation
journal, May 2007

  • Satoh, Wataru; Shimizu, Yoshifumi; Kaneto, Takeshi
  • Sensors and Actuators B: Chemical, Vol. 123, Issue 2
  • DOI: 10.1016/j.snb.2006.10.028

Growth dynamics and gas transport mechanism of nanobubbles in graphene liquid cells
journal, February 2015

  • Shin, Dongha; Park, Jong Bo; Kim, Yong-Jin
  • Nature Communications, Vol. 6, Issue 1
  • DOI: 10.1038/ncomms7068

Surfactants for Bubble Removal against Buoyancy
journal, January 2016

  • Raza, Md. Qaisar; Kumar, Nirbhay; Raj, Rishi
  • Scientific Reports, Vol. 6, Issue 1
  • DOI: 10.1038/srep19113

Charged Nanoparticle Dynamics in Water Induced by Scanning Transmission Electron Microscopy
journal, February 2012

  • White, E. R.; Mecklenburg, Matthew; Shevitski, Brian
  • Langmuir, Vol. 28, Issue 8
  • DOI: 10.1021/la2048486

Nanoparticle Dynamics in a Nanodroplet
journal, March 2014

  • Lu, Jingyu; Aabdin, Zainul; Loh, N. Duane
  • Nano Letters, Vol. 14, Issue 4
  • DOI: 10.1021/nl500766j

Tracking Nanoparticle Diffusion and Interaction during Self-Assembly in a Liquid Cell
journal, December 2016


Imaging rotational dynamics of nanoparticles in liquid by 4D electron microscopy
journal, February 2017


Brownian Diffusion in a Dilute Dispersion of Droplets
journal, January 1999


Optimal diffusion coefficient estimation in single-particle tracking
journal, June 2012


The random walk's guide to anomalous diffusion: a fractional dynamics approach
journal, December 2000


A high-precision study of hindered diffusion near a wall
journal, September 2010

  • Sharma, Prerna; Ghosh, Shankar; Bhattacharya, S.
  • Applied Physics Letters, Vol. 97, Issue 10
  • DOI: 10.1063/1.3486123

Join the crowd
journal, September 2003

  • Ellis, R. John; Minton, Allen P.
  • Nature, Vol. 425, Issue 6953
  • DOI: 10.1038/425027a

Anomalous Diffusion of Proteins Due to Molecular Crowding
journal, November 2005


Anomalous Diffusion in Living Yeast Cells
journal, August 2004

  • Tolić-Nørrelykke, Iva Marija; Munteanu, Emilia-Laura; Thon, Genevieve
  • Physical Review Letters, Vol. 93, Issue 7
  • DOI: 10.1103/PhysRevLett.93.078102

Shape behavior of lipid vesicles as the basis of some cellular processes
journal, October 2002

  • Svetina, Sa?a; ?ek?, Bo?tjan
  • The Anatomical Record, Vol. 268, Issue 3
  • DOI: 10.1002/ar.10156

A microscopic investigation of bubble formation nuclei
journal, November 1984

  • Yount, D. E.; Gillary, E. W.; Hoffman, D. C.
  • The Journal of the Acoustical Society of America, Vol. 76, Issue 5
  • DOI: 10.1121/1.391434

Role of Surface Tension in Gas Nanobubble Stability Under Ultrasound
journal, March 2018

  • Hernandez, Christopher; Nieves, Lenitza; de Leon, Al C.
  • ACS Applied Materials & Interfaces, Vol. 10, Issue 12
  • DOI: 10.1021/acsami.7b19755

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
journal, January 2017


Therapeutic applications of lipid-coated microbubbles
journal, May 2004


International Tables of the Surface Tension of Water
journal, July 1983

  • Vargaftik, N. B.; Volkov, B. N.; Voljak, L. D.
  • Journal of Physical and Chemical Reference Data, Vol. 12, Issue 3
  • DOI: 10.1063/1.555688

Bubble nucleation in liquids
journal, September 1975


Mechanics of membrane fusion
journal, July 2008

  • Chernomordik, Leonid V.; Kozlov, Michael M.
  • Nature Structural & Molecular Biology, Vol. 15, Issue 7
  • DOI: 10.1038/nsmb.1455

Microfluidic Assembly of Monodisperse Vesosomes as Artificial Cell Models
journal, December 2016

  • Deng, Nan-Nan; Yelleswarapu, Maaruthy; Zheng, Lifei
  • Journal of the American Chemical Society, Vol. 139, Issue 2
  • DOI: 10.1021/jacs.6b10977

Microfluidic control of cell pairing and fusion
journal, January 2009

  • Skelley, Alison M.; Kirak, Oktay; Suh, Heikyung
  • Nature Methods, Vol. 6, Issue 2
  • DOI: 10.1038/nmeth.1290

Liposomes in Polymersomes: Multicompartment System with Temperature-Triggered Release
journal, July 2017


Light-triggered enzymatic reactions in nested vesicle reactors
journal, March 2018


Polymer-Coated Echogenic Lipid Nanoparticles with Dual Release Triggers
journal, February 2013

  • Nahire, Rahul; Haldar, Manas K.; Paul, Shirshendu
  • Biomacromolecules, Vol. 14, Issue 3
  • DOI: 10.1021/bm301894z

Encapsulated microbubbles and echogenic liposomes for contrast ultrasound imaging and targeted drug delivery
journal, January 2014


Ultrasonically triggered drug delivery: Breaking the barrier
journal, November 2014


Uncovering the intrinsic size dependence of hydriding phase transformations in nanocrystals
journal, August 2013

  • Bardhan, Rizia; Hedges, Lester O.; Pint, Cary L.
  • Nature Materials, Vol. 12, Issue 10
  • DOI: 10.1038/nmat3716

In situ monitoring of exopolymer-dependent Mn mineralization on bacterial surfaces
journal, July 2020

  • Couasnon, Thaïs; Alloyeau, Damien; Ménez, Bénédicte
  • Science Advances, Vol. 6, Issue 27
  • DOI: 10.1126/sciadv.aaz3125

Design Rules for One-Step Seeded Growth of Nanocrystals: Threading the Needle between Secondary Nucleation and Ripening
journal, May 2019


Precursor reaction kinetics control compositional grading and size of CdSe 1−x S x nanocrystal heterostructures
journal, January 2019

  • Hamachi, Leslie S.; Yang, Haoran; Jen-La Plante, Ilan
  • Chemical Science, Vol. 10, Issue 26
  • DOI: 10.1039/C9SC00989B

Elucidating the Weakly Reversible Cs–Pb–Br Perovskite Nanocrystal Reaction Network with High-Throughput Maps and Transformations
journal, June 2020

  • Dahl, Jakob C.; Wang, Xingzhi; Huang, Xiao
  • Journal of the American Chemical Society, Vol. 142, Issue 27
  • DOI: 10.1021/jacs.0c04997