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Title: Characterization of SETD3 methyltransferase-mediated protein methionine methylation

Authors:
; ; ; ; ; ; ; ;  [1]
  1. Emory-MED
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
National Institutes of Health (NIH)
OSTI Identifier:
1669126
Resource Type:
Journal Article
Journal Name:
J. Biol. Chem.
Additional Journal Information:
Journal Volume: 295; Journal Issue: (32) ; 09, 2020
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Dai, Shaobo, Holt, Matthew V., Horton, John R., Woodcock, Clayton B., Patel, Anamika, Zhang, Xing, Young, Nicolas L., Wilkinson, Alex W., Cheng, Xiaodong, Baylor), Stanford), and Texas-MED). Characterization of SETD3 methyltransferase-mediated protein methionine methylation. United States: N. p., 2020. Web. doi:10.1074/jbc.RA120.014072.
Dai, Shaobo, Holt, Matthew V., Horton, John R., Woodcock, Clayton B., Patel, Anamika, Zhang, Xing, Young, Nicolas L., Wilkinson, Alex W., Cheng, Xiaodong, Baylor), Stanford), & Texas-MED). Characterization of SETD3 methyltransferase-mediated protein methionine methylation. United States. doi:10.1074/jbc.RA120.014072.
Dai, Shaobo, Holt, Matthew V., Horton, John R., Woodcock, Clayton B., Patel, Anamika, Zhang, Xing, Young, Nicolas L., Wilkinson, Alex W., Cheng, Xiaodong, Baylor), Stanford), and Texas-MED). Mon . "Characterization of SETD3 methyltransferase-mediated protein methionine methylation". United States. doi:10.1074/jbc.RA120.014072.
@article{osti_1669126,
title = {Characterization of SETD3 methyltransferase-mediated protein methionine methylation},
author = {Dai, Shaobo and Holt, Matthew V. and Horton, John R. and Woodcock, Clayton B. and Patel, Anamika and Zhang, Xing and Young, Nicolas L. and Wilkinson, Alex W. and Cheng, Xiaodong and Baylor) and Stanford) and Texas-MED)},
abstractNote = {},
doi = {10.1074/jbc.RA120.014072},
journal = {J. Biol. Chem.},
number = (32) ; 09, 2020,
volume = 295,
place = {United States},
year = {2020},
month = {9}
}

Works referenced in this record:

Epigenetic modifications of histones in cancer
journal, November 2019


Automethylation Activities within the Mixed Lineage Leukemia-1 (MLL1) Core Complex Reveal Evidence Supporting a “Two-active Site” Model for Multiple Histone H3 Lysine 4 Methylation
journal, November 2013

  • Patel, Anamika; Vought, Valarie E.; Swatkoski, Stephen
  • Journal of Biological Chemistry, Vol. 289, Issue 2
  • DOI: 10.1074/jbc.M113.501064

SETD3 protein is the actin-specific histidine N-methyltransferase
journal, December 2018

  • Kwiatkowski, Sebastian; Seliga, Agnieszka K.; Vertommen, Didier
  • eLife, Vol. 7
  • DOI: 10.7554/eLife.37921

Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism?
journal, November 2006


Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase
journal, July 2016


Likelihood-enhanced fast rotation functions
journal, February 2004

  • Storoni, Laurent C.; McCoy, Airlie J.; Read, Randy J.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 3
  • DOI: 10.1107/S0907444903028956

Mobile and localized protons: a framework for understanding peptide dissociation
journal, December 2000


THE NATURE OF THE ACTIVE METHYL DONOR FORMED ENZYMATICALLY FROM L-METHIONINE AND ADENOSINETRIPHOSPHATE 1,2
journal, June 1952

  • Cantoni, G. L.
  • Journal of the American Chemical Society, Vol. 74, Issue 11
  • DOI: 10.1021/ja01131a519

A Novel Automethylation Reaction in the Aspergillus nidulans LaeA Protein Generates S -Methylmethionine
journal, March 2013

  • Patananan, Alexander N.; Palmer, Jonathan M.; Garvey, Graeme S.
  • Journal of Biological Chemistry, Vol. 288, Issue 20
  • DOI: 10.1074/jbc.M113.465765

A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading
journal, September 2016


Thiopurine S-Methyltransferase as a Pharmacogenetic Biomarker: Significance of Testing and Review of Major Methods
journal, November 2017

  • Asadov, Chingiz; Aliyeva, Gunay; Mustafayeva, Kamala
  • Cardiovascular & Hematological Agents in Medicinal Chemistry, Vol. 15, Issue 1
  • DOI: 10.2174/1871525715666170529091921

Introduction to the multi-author review on methylation in cellular physiology
journal, June 2019


The molecular hallmarks of epigenetic control
journal, June 2016

  • Allis, C. David; Jenuwein, Thomas
  • Nature Reviews Genetics, Vol. 17, Issue 8
  • DOI: 10.1038/nrg.2016.59

Betaine-Homocysteine S -Methyltransferase-2 Is an S -Methylmethionine-Homocysteine Methyltransferase
journal, January 2008

  • Szegedi, Sandra S.; Castro, Carmen C.; Koutmos, Markos
  • Journal of Biological Chemistry, Vol. 283, Issue 14
  • DOI: 10.1074/jbc.M710449200

EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma
journal, April 2019

  • Hübner, Jens-Martin; Müller, Torsten; Papageorgiou, Dimitris N.
  • Neuro-Oncology, Vol. 21, Issue 7
  • DOI: 10.1093/neuonc/noz058

An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation
journal, January 2020

  • Dai, Shaobo; Horton, John R.; Wilkinson, Alex W.
  • Journal of Biological Chemistry, Vol. 295, Issue 9
  • DOI: 10.1074/jbc.RA119.012319

S -adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3
journal, May 2016

  • Jayaram, Hariharan; Hoelper, Dominik; Jain, Siddhant U.
  • Proceedings of the National Academy of Sciences, Vol. 113, Issue 22
  • DOI: 10.1073/pnas.1605523113

A Methylation-Dependent Electrostatic Switch Controls DNA Repair and Transcriptional Activation by E. coli Ada
journal, October 2005


PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism
journal, May 2019


Use of knowledge-based restraints in phenix.refine to improve macromolecular refinement at low resolution
journal, March 2012

  • Headd, Jeffrey J.; Echols, Nathaniel; Afonine, Pavel V.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 68, Issue 4
  • DOI: 10.1107/S0907444911047834

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
journal, January 2012

  • Schwartzentruber, Jeremy; Korshunov, Andrey; Liu, Xiao-Yang
  • Nature, Vol. 482, Issue 7384
  • DOI: 10.1038/nature10833

Reducing risk in thiopurine therapy
journal, November 2019


Structural Basis of LSD1-CoREST Selectivity in Histone H3 Recognition
journal, May 2007

  • Forneris, Federico; Binda, Claudia; Adamo, Antonio
  • Journal of Biological Chemistry, Vol. 282, Issue 28
  • DOI: 10.1074/jbc.C700100200

Histone-modifying enzymes: regulators of developmental decisions and drivers of human disease
journal, April 2012

  • Butler, Jill S.; Koutelou, Evangelia; Schibler, Andria C.
  • Epigenomics, Vol. 4, Issue 2
  • DOI: 10.2217/epi.12.3

Discovery and characterisation of the automethylation properties of PRDM9
journal, March 2017

  • Koh-Stenta, Xiaoying; Poulsen, Anders; Li, Rong
  • Biochemical Journal, Vol. 474, Issue 6
  • DOI: 10.1042/BCJ20161067

Pharmacogenomics: Catechol O-Methyltransferase to Thiopurine S-Methyltransferase
journal, June 2006


CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism
journal, July 2019

  • Piunti, Andrea; Smith, Edwin R.; Morgan, Marc A. J.
  • Science Advances, Vol. 5, Issue 7
  • DOI: 10.1126/sciadv.aax2887

Coot model-building tools for molecular graphics
journal, November 2004

  • Emsley, Paul; Cowtan, Kevin
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132
  • DOI: 10.1107/S0907444904019158

Purification and Functional Characterization of a Histone H3-Lysine 4-Specific Methyltransferase
journal, December 2001


Enterovirus pathogenesis requires the host methyltransferase SETD3
journal, September 2019


Features and development of Coot
journal, March 2010

  • Emsley, P.; Lohkamp, B.; Scott, W. G.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4
  • DOI: 10.1107/S0907444910007493

Nonhistone Lysine Methylation in the Regulation of Cancer Pathways
journal, August 2016


Histone H3 Mutations: An Updated View of Their Role in Chromatin Deregulation and Cancer
journal, May 2019


A Mouse Speciation Gene Encodes a Meiotic Histone H3 Methyltransferase
journal, January 2009


Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme
journal, December 1991

  • Dao-Pin, S.; Anderson, D. E.; Baase, W. A.
  • Biochemistry, Vol. 30, Issue 49
  • DOI: 10.1021/bi00113a006

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells
journal, August 2019

  • Ragazzini, Roberta; Pérez-Palacios, Raquel; Baymaz, Irem H.
  • Nature Communications, Vol. 10, Issue 1
  • DOI: 10.1038/s41467-019-11800-x

Historical review: the field of protein methylation
journal, March 2007


Methyltransferase-Glo: a universal, bioluminescent and homogenous assay for monitoring all classes of methyltransferases
journal, March 2016

  • Hsiao, Kevin; Zegzouti, Hicham; Goueli, Said A.
  • Epigenomics, Vol. 8, Issue 3
  • DOI: 10.2217/epi.15.113

Structural basis for the target specificity of actin histidine methyltransferase SETD3
journal, August 2019


Structural insights into SETD3-mediated histidine methylation on β-actin
journal, February 2019


Many paths to methyltransfer: a chronicle of convergence
journal, June 2003


SETD3 is an actin histidine methyltransferase that prevents primary dystocia
journal, December 2018


Carbon-Oxygen Hydrogen Bonding in Biological Structure and Function
journal, October 2012

  • Horowitz, Scott; Trievel, Raymond C.
  • Journal of Biological Chemistry, Vol. 287, Issue 50
  • DOI: 10.1074/jbc.R112.418574

Post-translational modifications and chromatin dynamics
journal, March 2019

  • Tolsma, Thomas O.; Hansen, Jeffrey C.
  • Essays in Biochemistry, Vol. 63, Issue 1
  • DOI: 10.1042/EBC20180067

Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
journal, April 2016

  • Justin, Neil; Zhang, Ying; Tarricone, Cataldo
  • Nature Communications, Vol. 7, Issue 1
  • DOI: 10.1038/ncomms11316

Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation
journal, December 2011


Multiparametric scaling of diffraction intensities
journal, April 2003

  • Otwinowski, Zbyszek; Borek, Dominika; Majewski, Wladyslaw
  • Acta Crystallographica Section A Foundations of Crystallography, Vol. 59, Issue 3
  • DOI: 10.1107/S0108767303005488

Self-methylation of BspRI DNA-methyltransferase
journal, January 1994

  • Szilák, László; Finta, Csaba; Patthy, András
  • Nucleic Acids Research, Vol. 22, Issue 15
  • DOI: 10.1093/nar/22.15.2876

Phaser crystallographic software
journal, July 2007

  • McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D.
  • Journal of Applied Crystallography, Vol. 40, Issue 4
  • DOI: 10.1107/S0021889807021206

Methylation pharmacogenetics: Thiopurine methyltransferase as a model system
journal, January 1992


Chromatographic quantitation of free amino acids: S‐methylmethionine, methionine and lysine in corn
journal, July 1991


Protein methylation
journal, December 1993