Silica Nanodepletors: Targeting and Clearing Alzheimer's beta-Amyloid Plaques

Jung, Huijin; Chung, You Jung; Wilton, Rosemarie; Lee, Chang Heon; Lee, Byung Il; Lim, Jinyeong; Lee, Hyojin; Choi, Jong-Ho; Kang, Hyuno; Lee, Byeongdu; Rozhkova, Elena A.; Park, Chan Beum; Lee, Joonseok

doi:10.1002/adfm.201910475

Title: Silica Nanodepletors: Targeting and Clearing Alzheimer's beta-Amyloid Plaques

Journal Article · Wed Apr 01 00:00:00 EDT 2020 · Advanced Functional Materials (Online)

DOI:https://doi.org/10.1002/adfm.201910475· OSTI ID:1660950

Jung, Huijin; Chung, You Jung; Wilton, Rosemarie; Lee, Chang Heon; Lee, Byung Il; Lim, Jinyeong; Lee, Hyojin; Choi, Jong-Ho; Kang, Hyuno; Lee, Byeongdu; Rozhkova, Elena A.; Park, Chan Beum; Lee, Joonseok

Abnormal accumulation of beta-amyloid (A beta) peptide aggregates in the brain is a major hallmark of Alzheimer's disease (AD). A beta aggregates interfere with neuronal communications, ultimately causing neuronal damage and brain atrophy. Much effort has been made to develop AD treatments that suppress A beta aggregate formation, thereby attenuating A beta-induced neurotoxicity. Here, the design of A beta nanodepletors consisting of ultralarge mesoporous silica nanostructures and anti-A beta single-chain variable fragments, with the goal of targeting and eliminating aggregative A beta monomers, is reported. The A beta nanodepletors impart a notable decline in A beta aggregate formation, resulting in significant mitigation of A beta-induced neurotoxicity in vitro. Furthermore, stereotaxic injections of A beta nanodepletors into the brain of an AD mouse model system successfully suppress A beta plaque formation in vivo up to approximate to 30%, suggesting that A beta nanodepletors can serve as a promising antiamylodoisis material.

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Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States)

Sponsoring Organization:: Korea Institute of Science and Technology (KIST); National Research Foundation of Korea (NRF); USDOE Office of Science (SC), Basic Energy Sciences (BES)

DOE Contract Number:: AC02-06CH11357

OSTI ID:: 1660950

Journal Information:: Advanced Functional Materials (Online), Vol. 30, Issue 15

Country of Publication:: United States

Language:: English

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