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Title: Structural Tunability of Multicompartment Micelles as a Function of Lipophilic–Fluorophilic Block Length Ratio

Abstract

Structural variation in multicompartment micelles consisting of lipophilic–hydrophilic–fluorophilic (hereafter referred to as BAC) triblock copolymers is investigated using the dissipative particle dynamics simulation method. It is demonstrated from our results that the structure of BAC multicompartment micelles is effectively tuned as a function of the lipophilic–fluorophilic ratio parameter, here termed $$R_1$$, of the constituent linear triblock copolymers. In particular, a morphological deviation from onion-like ABC micelles arises in BAC micelle systems as $$R_1$$ increases. The morphologies of BAC micelles with $$R_1\ll$$1 or $$R_1\gg$$1 display striking similarities, with the only notable difference being an inversion of the lipophilic and fluorophilic regions. When $$R\approx$$ 1, segmented worm-like structures with multiple cores are favored in BAC micelle systems. Through this study, it is confirmed that the block length ratio is an effective control parameter to tune the structure of multicompartment micelles.

Authors:
 [1];  [1];  [1];  [1]; ORCiD logo [1]
  1. Georgia Inst. of Technology, Atlanta, GA (United States)
Publication Date:
Research Org.:
Georgia Inst. of Technology, Atlanta, GA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI Identifier:
1657067
Grant/Contract Number:  
FG02-03ER15459
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Journal of Physical Chemistry. B, Condensed Matter, Materials, Surfaces, Interfaces and Biophysical Chemistry
Additional Journal Information:
Journal Volume: 122; Journal Issue: 50; Journal ID: ISSN 1520-6106
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; 97 MATHEMATICS AND COMPUTING; Multicompartment Micelle; Block Length Ratio; Dissipative Particle Dynamics Simulation

Citation Formats

Callaway, Connor P., Bond, Nicholas, Hendrickson, Kayla, Lee, Seung Min, and Jang, Seung Soon. Structural Tunability of Multicompartment Micelles as a Function of Lipophilic–Fluorophilic Block Length Ratio. United States: N. p., 2018. Web. doi:10.1021/acs.jpcb.8b07769.
Callaway, Connor P., Bond, Nicholas, Hendrickson, Kayla, Lee, Seung Min, & Jang, Seung Soon. Structural Tunability of Multicompartment Micelles as a Function of Lipophilic–Fluorophilic Block Length Ratio. United States. https://doi.org/10.1021/acs.jpcb.8b07769
Callaway, Connor P., Bond, Nicholas, Hendrickson, Kayla, Lee, Seung Min, and Jang, Seung Soon. Wed . "Structural Tunability of Multicompartment Micelles as a Function of Lipophilic–Fluorophilic Block Length Ratio". United States. https://doi.org/10.1021/acs.jpcb.8b07769. https://www.osti.gov/servlets/purl/1657067.
@article{osti_1657067,
title = {Structural Tunability of Multicompartment Micelles as a Function of Lipophilic–Fluorophilic Block Length Ratio},
author = {Callaway, Connor P. and Bond, Nicholas and Hendrickson, Kayla and Lee, Seung Min and Jang, Seung Soon},
abstractNote = {Structural variation in multicompartment micelles consisting of lipophilic–hydrophilic–fluorophilic (hereafter referred to as BAC) triblock copolymers is investigated using the dissipative particle dynamics simulation method. It is demonstrated from our results that the structure of BAC multicompartment micelles is effectively tuned as a function of the lipophilic–fluorophilic ratio parameter, here termed $R_1$, of the constituent linear triblock copolymers. In particular, a morphological deviation from onion-like ABC micelles arises in BAC micelle systems as $R_1$ increases. The morphologies of BAC micelles with $R_1\ll$1 or $R_1\gg$1 display striking similarities, with the only notable difference being an inversion of the lipophilic and fluorophilic regions. When $R\approx$ 1, segmented worm-like structures with multiple cores are favored in BAC micelle systems. Through this study, it is confirmed that the block length ratio is an effective control parameter to tune the structure of multicompartment micelles.},
doi = {10.1021/acs.jpcb.8b07769},
url = {https://www.osti.gov/biblio/1657067}, journal = {Journal of Physical Chemistry. B, Condensed Matter, Materials, Surfaces, Interfaces and Biophysical Chemistry},
issn = {1520-6106},
number = 50,
volume = 122,
place = {United States},
year = {2018},
month = {11}
}

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