A multi-modal sweat sensing patch for cross-verification of sweat rate, total ionic charge, and Na+ concentration

Yuan, Zhen; Hou, Lei; Bariya, Mallika; Nyein, Hnin Yin Yin; Tai, Li-Chia; Ji, Wenbo; Li, Lu; Javey, Ali

doi:10.1039/c9lc00598f

Title: A multi-modal sweat sensing patch for cross-verification of sweat rate, total ionic charge, and Na⁺ concentration

Abstract

Sweat sensors introduced in recent years have targeted a variety of sweat features and biomarkers for non-invasive health monitoring. Amongst these targets, reliable monitoring of sweat rate is crucial due to its modulation of sweat analyte concentrations and its intrinsic significance to numerous medical and physiological health conditions. In this paper, we present a sweat rate sensor structure comprising of electrodes with interdigitated fingers in a microfluidic channel. Each time the accumulating sweat impinges on an electrode finger, the sensor reports a jump in admittance that can be simply and efficiently counted to estimate sweat rate, overcoming selectivity limitations of previously reported sweat rate sensors. We further integrate an impedimetric sensor for measuring total ionic charge concentration and an electrochemical Na⁺ sensor, together creating a multi-modal system for analyzing fluid and electrolyte secretion. We demonstrate how low analyte diffusion rates through this microfluidic device allow for multi-purpose sensor function, including utilizing the sweat rate sensor signal to corroborate total ionic sensor measurements. This cross-verification capability ensures data integrity in real time, satisfying a vital consideration for personalized healthcare technologies. We use the presented patch for continuous analysis of sweat rate, total ionic charge concentration, and Na⁺ concentration during exercise, whilemore »« less

Authors:

Yuan, Zhen ^[1]; Hou, Lei ^[1];

^[1]; Nyein, Hnin Yin Yin ^[1]; Tai, Li-Chia ^[1]; Ji, Wenbo ^[1]; Li, Lu ^[1]; Javey, Ali ^[1]

Univ. of California, Berkeley, CA (United States). Dept. of Electrical Engineering and Computer Sciences and Berkeley Sensor and Actuator Center; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division

Publication Date:: Mon Aug 19 00:00:00 EDT 2019

Research Org.:: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Sponsoring Org.:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division; National Science Foundation (NSF)

OSTI Identifier:: 1638996

Grant/Contract Number:: AC02-05CH11231

Resource Type:: Journal Article: Accepted Manuscript

Journal Name:: Lab on a Chip

Additional Journal Information:: Journal Volume: 19; Journal Issue: 19; Journal ID: ISSN 1473-0197

Publisher:: Royal Society of Chemistry

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

Citation Formats


                    Yuan, Zhen, Hou, Lei, Bariya, Mallika, Nyein, Hnin Yin Yin, Tai, Li-Chia, Ji, Wenbo, Li, Lu, and Javey, Ali. A multi-modal sweat sensing patch for cross-verification of sweat rate, total ionic charge, and Na+ concentration.  United States: N. p., 2019. 
        Web.  doi:10.1039/c9lc00598f.

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                    Yuan, Zhen, Hou, Lei, Bariya, Mallika, Nyein, Hnin Yin Yin, Tai, Li-Chia, Ji, Wenbo, Li, Lu, & Javey, Ali. A multi-modal sweat sensing patch for cross-verification of sweat rate, total ionic charge, and Na+ concentration.  United States.  https://doi.org/10.1039/c9lc00598f

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                    Yuan, Zhen, Hou, Lei, Bariya, Mallika, Nyein, Hnin Yin Yin, Tai, Li-Chia, Ji, Wenbo, Li, Lu, and Javey, Ali. 2019.  
        "A multi-modal sweat sensing patch for cross-verification of sweat rate, total ionic charge, and Na+ concentration".  United States.  https://doi.org/10.1039/c9lc00598f.  https://www.osti.gov/servlets/purl/1638996.

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@article{osti_1638996,

  title        = {A multi-modal sweat sensing patch for cross-verification of sweat rate, total ionic charge, and Na+ concentration},

  author       = {Yuan, Zhen and Hou, Lei and Bariya, Mallika and Nyein, Hnin Yin Yin and Tai, Li-Chia and Ji, Wenbo and Li, Lu and Javey, Ali},

  abstractNote = {Sweat sensors introduced in recent years have targeted a variety of sweat features and biomarkers for non-invasive health monitoring. Amongst these targets, reliable monitoring of sweat rate is crucial due to its modulation of sweat analyte concentrations and its intrinsic significance to numerous medical and physiological health conditions. In this paper, we present a sweat rate sensor structure comprising of electrodes with interdigitated fingers in a microfluidic channel. Each time the accumulating sweat impinges on an electrode finger, the sensor reports a jump in admittance that can be simply and efficiently counted to estimate sweat rate, overcoming selectivity limitations of previously reported sweat rate sensors. We further integrate an impedimetric sensor for measuring total ionic charge concentration and an electrochemical Na+ sensor, together creating a multi-modal system for analyzing fluid and electrolyte secretion. We demonstrate how low analyte diffusion rates through this microfluidic device allow for multi-purpose sensor function, including utilizing the sweat rate sensor signal to corroborate total ionic sensor measurements. This cross-verification capability ensures data integrity in real time, satisfying a vital consideration for personalized healthcare technologies. We use the presented patch for continuous analysis of sweat rate, total ionic charge concentration, and Na+ concentration during exercise, while demonstrating how multi-modal cross-verification brings new trust to sensor readings.},

  doi          = {10.1039/c9lc00598f},

  url          = {https://www.osti.gov/biblio/1638996},
  journal      = {Lab on a Chip},

  issn         = {1473-0197},

  number       = 19,

  volume       = 19,

  place        = {United States},

  year         = {Mon Aug 19 00:00:00 EDT 2019},

  month        = {Mon Aug 19 00:00:00 EDT 2019}

}

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Ultra-simple wearable local sweat volume monitoring patch based on swellable hydrogels
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Title: A multi-modal sweat sensing patch for cross-verification of sweat rate, total ionic charge, and Na+ concentration

Abstract

Citation Formats

Toward Flexible and Wearable Human-Interactive Health-Monitoring Devices journal, November 2014

Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics journal, April 2010

The microfluidics of the eccrine sweat gland, including biomarker partitioning, transport, and biosensing implications journal, May 2015

Soft Microfluidic Assemblies of Sensors, Circuits, and Radios for the Skin journal, April 2014

A wearable electrochemical sensor for the real-time measurement of sweat sodium concentration journal, January 2010

Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis journal, January 2016

Wearable sweat sensors journal, March 2018

A Wearable Microfluidic Sensing Patch for Dynamic Sweat Secretion Analysis journal, May 2018

Roll-to-Roll Gravure Printed Electrochemical Sensors for Wearable and Medical Devices journal, June 2018

Epidermal Electronics journal, August 2011

Effects of oral salt supplementation on physical performance during a half-ironman: A randomized controlled trial: Salt supplementation during triathlon races journal, February 2015

Anaerobic performance when rehydrating with water or commercially available sports drinks during prolonged exercise in the heat journal, April 2008

Sweat Composition in Relation to Rate of Sweating in Patients with Cystic Fibrosis of the Pancreas journal, November 1968

Pursuing prosthetic electronic skin journal, July 2016

Application of 3D Printing for Smart Objects with Embedded Electronic Sensors and Systems journal, March 2016

Materials and Mechanics for Stretchable Electronics journal, March 2010

Soft, Skin-Interfaced Microfluidic Systems with Wireless, Battery-Free Electronics for Digital, Real-Time Tracking of Sweat Loss and Electrolyte Composition journal, October 2018

Acute effects of dehydration on sweat composition in men during prolonged exercise in the heat journal, September 2004

Methylxanthine Drug Monitoring with Wearable Sweat Sensors journal, April 2018

Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring journal, April 2014

Printed Carbon Nanotube Electronics and Sensor Systems journal, February 2016

Flexible polymer transistors with high pressure sensitivity for application in electronic skin and health monitoring journal, May 2013

Studies of salt excretion in sweat journal, June 1963

Asymmetric sweating in stroke: A prospective quantitative study of patients with hemispheral brain infarction journal, June 1993

Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids journal, May 2016

A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca 2+ and pH journal, July 2016

Effects of Dehydration on Exercise Performance journal, April 1999

Sweat Mineral-Element Responses during 7 h of Exercise-Heat Stress journal, December 2007

Highly deformable liquid-state heterojunction sensors journal, September 2014

Seven-Year Clinical Surveillance Program Demonstrates Consistent MARD Accuracy Performance of a Blood Glucose Test Strip journal, May 2018

Ultra-simple wearable local sweat volume monitoring patch based on swellable hydrogels journal, January 2020

Title: A multi-modal sweat sensing patch for cross-verification of sweat rate, total ionic charge, and Na⁺ concentration

Toward Flexible and Wearable Human-Interactive Health-Monitoring Devices
journal, November 2014

Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics
journal, April 2010

The microfluidics of the eccrine sweat gland, including biomarker partitioning, transport, and biosensing implications
journal, May 2015

Soft Microfluidic Assemblies of Sensors, Circuits, and Radios for the Skin
journal, April 2014

A wearable electrochemical sensor for the real-time measurement of sweat sodium concentration
journal, January 2010

Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis
journal, January 2016

Wearable sweat sensors
journal, March 2018

A Wearable Microfluidic Sensing Patch for Dynamic Sweat Secretion Analysis
journal, May 2018

Roll-to-Roll Gravure Printed Electrochemical Sensors for Wearable and Medical Devices
journal, June 2018

Epidermal Electronics
journal, August 2011

Effects of oral salt supplementation on physical performance during a half-ironman: A randomized controlled trial: Salt supplementation during triathlon races
journal, February 2015

Anaerobic performance when rehydrating with water or commercially available sports drinks during prolonged exercise in the heat
journal, April 2008

Sweat Composition in Relation to Rate of Sweating in Patients with Cystic Fibrosis of the Pancreas
journal, November 1968

Pursuing prosthetic electronic skin
journal, July 2016

Application of 3D Printing for Smart Objects with Embedded Electronic Sensors and Systems
journal, March 2016

Materials and Mechanics for Stretchable Electronics
journal, March 2010

Soft, Skin-Interfaced Microfluidic Systems with Wireless, Battery-Free Electronics for Digital, Real-Time Tracking of Sweat Loss and Electrolyte Composition
journal, October 2018

Acute effects of dehydration on sweat composition in men during prolonged exercise in the heat
journal, September 2004

Methylxanthine Drug Monitoring with Wearable Sweat Sensors
journal, April 2018

Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring
journal, April 2014

Printed Carbon Nanotube Electronics and Sensor Systems
journal, February 2016

Flexible polymer transistors with high pressure sensitivity for application in electronic skin and health monitoring
journal, May 2013

Studies of salt excretion in sweat
journal, June 1963

Asymmetric sweating in stroke: A prospective quantitative study of patients with hemispheral brain infarction
journal, June 1993

Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids
journal, May 2016

A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca ²⁺ and pH
journal, July 2016

Effects of Dehydration on Exercise Performance
journal, April 1999

Sweat Mineral-Element Responses during 7 h of Exercise-Heat Stress
journal, December 2007

Highly deformable liquid-state heterojunction sensors
journal, September 2014

Seven-Year Clinical Surveillance Program Demonstrates Consistent MARD Accuracy Performance of a Blood Glucose Test Strip
journal, May 2018

Ultra-simple wearable local sweat volume monitoring patch based on swellable hydrogels
journal, January 2020