skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Host cells and methods for oxidizing aromatic amino acids

Abstract

The present invention provides for a method of producing an oxidation product of an aromatic amino acid in a genetically modified host cell. The method comprises culturing the genetically modified host cell under a suitable condition such that the culturing results in the genetically modified host cell producing oxidation product of an aromatic amino acid. The host cell comprises an enzyme capable of catalyzing the oxidation of aromatic amino acid. In some embodiments, the host cell is capable of biosynthesizing BH4 or MH4 from GTP.

Inventors:
; ;
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1637795
Patent Number(s):
10,597,685
Application Number:
14/042,270
Assignee:
The Regents of the University of California (Oakland, CA)
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 09/30/2013
Country of Publication:
United States
Language:
English

Citation Formats

Lee, Taek Soon, Satoh, Yasuharu, and Keasling, Jay D. Host cells and methods for oxidizing aromatic amino acids. United States: N. p., 2020. Web.
Lee, Taek Soon, Satoh, Yasuharu, & Keasling, Jay D. Host cells and methods for oxidizing aromatic amino acids. United States.
Lee, Taek Soon, Satoh, Yasuharu, and Keasling, Jay D. Tue . "Host cells and methods for oxidizing aromatic amino acids". United States. https://www.osti.gov/servlets/purl/1637795.
@article{osti_1637795,
title = {Host cells and methods for oxidizing aromatic amino acids},
author = {Lee, Taek Soon and Satoh, Yasuharu and Keasling, Jay D.},
abstractNote = {The present invention provides for a method of producing an oxidation product of an aromatic amino acid in a genetically modified host cell. The method comprises culturing the genetically modified host cell under a suitable condition such that the culturing results in the genetically modified host cell producing oxidation product of an aromatic amino acid. The host cell comprises an enzyme capable of catalyzing the oxidation of aromatic amino acid. In some embodiments, the host cell is capable of biosynthesizing BH4 or MH4 from GTP.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {3}
}

Patent:

Save / Share:

Works referenced in this record:

Inhibitors of sorotonin N-acetyltransferase
patent, November 1999


Process for production of biopterin compound
patent, October 2010


Methods of treating Parkinson's disease using recombinant adeno-associated virus virions
patent, September 2009


Genetically modified tyrosine hydroxylase and uses thereof
patent, May 1993


Therapeutic Gene
patent, April 2003


Genetically engineered cells that produce produce L. Dopa
patent, August 2000