Systems and methods for relay ionization

Cooks, Robert Graham; Li, Anyin; Hollerbach, Adam

Systems and methods for relay ionization

Patent · 02 March 2020

OSTI ID:1632639

Cooks, Robert Graham; Li, Anyin; Hollerbach, Adam

The invention generally relates to systems and methods for relay ionization of a sample. In certain aspects, the invention provides systems that include an ion source that generates ions, a sample emitter configured to hold a sample, and a mass spectrometer. The system is configured such that the ions generated by the ion source are directed to interact with the sample emitter, thereby causing the sample to be discharged from the sample emitter and into the mass spectrometer.

View Patent

Research Organization:: Purdue Research Foundation, West Lafayette, IN (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-06ER15807

Assignee:: Purdue Research Foundation (West Lafayette, IN)

Patent Number(s):: 10,580,634

Application Number:: 16/518,291

OSTI ID:: 1632639

Country of Publication:: United States

Language:: English

References (66)

Field induced ion evaporation from liquid surfaces at atmospheric pressure Thomson, B. A.; Iribarne, J. V. The Journal of Chemical Physics, Vol. 71, Issue 11 https://doi.org/10.1063/1.438198	journal	December 1979
Molecular Beams of Macroions Dole, Malcolm; Mack, L. L.; Hines, R. L. The Journal of Chemical Physics, Vol. 49, Issue 5 https://doi.org/10.1063/1.1670391	journal	September 1968
Three-dimensional microfluidic devices fabricated in layered paper and tape Martinez, A. W.; Phillips, S. T.; Whitesides, G. M. Proceedings of the National Academy of Sciences, Vol. 105, Issue 50, p. 19606-19611 https://doi.org/10.1073/pnas.0810903105	journal	December 2008
CD14 expression by human mononuclear phagocytes is modulated by Clostridium difficile toxin B Siffert, Jean-Claude; Müller, Christian D.; Dumont, Serge Microbes and Infection, Vol. 1, Issue 14 https://doi.org/10.1016/S1286-4579(99)00247-6	journal	December 1999
Interface solution isoelectric focusing with in situ MALDI-TOF mass spectrometry: Microfluidics and Miniaturization Wang, Shujun; Chen, Suming; Wang, Jianing ELECTROPHORESIS, Vol. 35, Issue 17 https://doi.org/10.1002/elps.201400083	journal	June 2014
Direct monitoring of toxic compounds in air using a portable mass spectrometer Mulligan, Christopher C.; Justes, Dina R.; Noll, Robert. J. The Analyst, Vol. 131, Issue 4, p. 556-567 https://doi.org/10.1039/b517541k	journal	February 2006
Electrospray-assisted laser desorption/ionization mass spectrometry for direct ambient analysis of solids Shiea, Jentaie; Huang, Min-Zon; HSu, Hsiu-Jung Rapid Communications in Mass Spectrometry, Vol. 19, Issue 24, p. 3701-3704 https://doi.org/10.1002/rcm.2243	journal	January 2005
Miniature Mass Spectrometers Ouyang, Zheng; Cooks, R. Graham Annual Review of Analytical Chemistry, Vol. 2, Issue 1 https://doi.org/10.1146/annurev-anchem-060908-155229	journal	July 2009
Live single-cell video-mass spectrometry for cellular and subcellular molecular detection and cell classification Mizuno, Hajime; Tsuyama, Naohiro; Harada, Takanori Journal of Mass Spectrometry, Vol. 43, Issue 12 https://doi.org/10.1002/jms.1460	journal	December 2008
In situ analysis of corrosion inhibitors using a portable mass spectrometer with paper spray ionization Jjunju, Fred. P. M.; Li, Anyin; Badu-Tawiah, Abraham The Analyst, Vol. 138, Issue 13, p. 3740-3748 https://doi.org/10.1039/c3an00249g	journal	January 2013
Electrospray ion source. Another variation on the free-jet theme Yamashita, Masamichi; Fenn, John B. The Journal of Physical Chemistry, Vol. 88, Issue 20 https://doi.org/10.1021/j150664a002	journal	September 1984
Electrospray ionization for mass spectrometry of large biomolecules Fenn, J.; Mann, M.; Meng, C. Science, Vol. 246, Issue 4926, p. 64-71 https://doi.org/10.1126/science.2675315	journal	October 1989
Peptide Cross-Linking at Ambient Surfaces by Reactions of Nanosprayed Molecular Cations Badu-Tawiah, Abraham K.; Li, Anyin; Jjunju, Fred P. M. Angewandte Chemie, Vol. 124, Issue 37, p. 9551-9555 https://doi.org/10.1002/ange.201205044	journal	August 2012
Direct analysis of 4-methylimidazole in foods using paper spray mass spectrometry Li, Anyin; Wei, Pu; Hsu, Hsu-Chen The Analyst, Vol. 138, Issue 16 https://doi.org/10.1039/c3an00888f	journal	January 2013
Arc-Free Atmospheric Pressure Cold Plasma Jets: A Review Laroussi, Mounir; Akan, Tamer Plasma Processes and Polymers, Vol. 4, Issue 9 https://doi.org/10.1002/ppap.200700066	journal	November 2007
Capillary Electrophoresis with Electrospray Ionization Mass Spectrometric Detection for Single-Cell Metabolomics Lapainis, Theodore; Rubakhin, Stanislav S.; Sweedler, Jonathan V. Analytical Chemistry, Vol. 81, Issue 14 https://doi.org/10.1021/ac900936g	journal	July 2009
Using Ambient Ion Beams to Write Nanostructured Patterns for Surface Enhanced Raman Spectroscopy Li, Anyin; Baird, Zane; Bag, Soumabha Angewandte Chemie International Edition https://doi.org/10.1002/anie.201406660	journal	September 2014
Electrospray Ionization Using Wooden Tips Hu, Bin; So, Pui-Kin; Chen, Huanwen Analytical Chemistry, Vol. 83, Issue 21 https://doi.org/10.1021/ac2017713	journal	November 2011
Monitoring of Reaction Intermediates in the Gas Phase: Ruthenium-Catalyzed C–C Coupling Škríba, Anton; Schulz, Jiří; Roithová, Jana Organometallics, Vol. 33, Issue 23 https://doi.org/10.1021/om500933w	journal	November 2014
Microfabricated electrospray emitter arrays with integrated extractor and accelerator electrodes for the propulsion of small spacecraft Dandavino, S.; Ataman, C.; Ryan, C. N. Journal of Micromechanics and Microengineering, Vol. 24, Issue 7 https://doi.org/10.1088/0960-1317/24/7/075011	journal	June 2014
Electrospray Ionization from Nanopipette Emitters with Tip Diameters of Less than 100 nm Yuill, Elizabeth M.; Sa, Niya; Ray, Steven J. Analytical Chemistry, Vol. 85, Issue 18 https://doi.org/10.1021/ac402214g	journal	August 2013
Patterned Paper as a Platform for Inexpensive, Low-Volume, Portable Bioassays Martinez, Andres W.; Phillips, Scott T.; Butte, Manish J. Angewandte Chemie International Edition, Vol. 46, Issue 8, p. 1318-1320 https://doi.org/10.1002/anie.200603817	journal	February 2007
Synthesis and Catalytic Reactions of Nanoparticles formed by Electrospray Ionization of Coinage Metals Li, Anyin; Luo, Qingjie; Park, So-Jung Angewandte Chemie International Edition, Vol. 53, Issue 12, p. 3147-3150 https://doi.org/10.1002/anie.201309193	journal	February 2014
Miniaturization of Mass Spectrometry Analysis Systems Xu, Wei; Manicke, Nicholas E.; Cooks, Graham R. JALA: Journal of the Association for Laboratory Automation, Vol. 15, Issue 6 https://doi.org/10.1016/j.jala.2010.06.004	journal	December 2010
Nanomole-scale high-throughput chemistry for the synthesis of complex molecules Buitrago Santanilla, Alexander; Regalado, Erik L.; Pereira, Tony Science, Vol. 347, Issue 6217 https://doi.org/10.1126/science.1259203	journal	November 2014
Analysis of Polycyclic Aromatic Hydrocarbons Using Desorption Atmospheric Pressure Chemical Ionization Coupled to a Portable Mass Spectrometer Jjunju, Fred P. M.; Maher, Simon; Li, Anyin Journal of the American Society for Mass Spectrometry, Vol. 26, Issue 2 https://doi.org/10.1007/s13361-014-1029-2	journal	December 2014
Efficiency of nano-electrospray ionization El-Faramawy, Ayman; Siu, K. W. Michael; Thomson, Bruce A. Journal of the American Society for Mass Spectrometry, Vol. 16, Issue 10 https://doi.org/10.1016/j.jasms.2005.06.011	journal	October 2005
New developments in biochemical mass spectrometry: electrospray ionization Smith, Richard D.; Loo, Joseph A.; Edmonds, Charles G. Analytical Chemistry, Vol. 62, Issue 9 https://doi.org/10.1021/ac00208a002	journal	May 1990
Theta-Glass Capillaries in Electrospray Ionization: Rapid Mixing and Short Droplet Lifetimes Mortensen, Daniel N.; Williams, Evan R. Analytical Chemistry, Vol. 86, Issue 18 https://doi.org/10.1021/ac502545r	journal	September 2014
Durable Gold-Coated Fused Silica Capillaries for Use in Electrospray Mass Spectrometry Kriger, M. Scott.; Cook, Kelsey D.; Ramsey, Roswitha S. Analytical Chemistry, Vol. 67, Issue 2 https://doi.org/10.1021/ac00098a025	journal	January 1995
Efficient Separations of Intact Proteins Using Slip-Flow with Nano-Liquid Chromatography–Mass Spectrometry Wu, Zhen; Wei, Bingchuan; Zhang, Ximo Analytical Chemistry, Vol. 86, Issue 3 https://doi.org/10.1021/ac403233d	journal	January 2014
FLASH: A rapid method for prototyping paper-based microfluidic devices Martinez, Andres W.; Phillips, Scott T.; Wiley, Benjamin J. Lab on a Chip, Vol. 8, Issue 12, p. 2146-2150 https://doi.org/10.1039/b811135a	journal	January 2008
Paper spray ionization of polar analytes using non-polar solvents Li, Anyin; Wang, He; Ouyang, Zheng Chemical Communications, Vol. 47, Issue 10 https://doi.org/10.1039/c0cc05513a	journal	January 2011
Desorption electrospray ionization with a portable mass spectrometer: in situ analysis of ambient surfaces Mulligan, Christopher C.; Talaty, Nari; Cooks, R. Graham Chemical Communications, Issue 16, p. 1709-1711 https://doi.org/10.1039/b517357d	journal	February 2006
Atmospheric pressure ionization mass spectrometry. Corona discharge ion source for use in a liquid chromatograph-mass spectrometer-computer analytical system Carroll, D. I.; Dzidic, I.; Stillwell, R. N. Analytical Chemistry, Vol. 47, Issue 14 https://doi.org/10.1021/ac60364a031	journal	December 1975
Paper-Based Microfluidic Devices by Plasma Treatment Li, Xu; Tian, Junfei; Nguyen, Thanh Analytical Chemistry, Vol. 80, Issue 23, p. 9131-9134 https://doi.org/10.1021/ac801729t	journal	December 2008
Enhanced detection of olefins using ambient ionization mass spectrometry: Ag+ adducts of biologically relevant alkenes Jackson, Ayanna U.; Shum, Thomas; Sokol, Ewa Analytical and Bioanalytical Chemistry, Vol. 399, Issue 1 https://doi.org/10.1007/s00216-010-4349-5	journal	November 2010
Electrochemical processes in a wire-in-a-capillary bulk-loaded, nano-electrospray emitter Berkel, Gary J.; Asano, Keiji G.; Schnier, Paul D. Journal of the American Society for Mass Spectrometry, Vol. 12, Issue 7 https://doi.org/10.1016/S1044-0305(01)00264-1	journal	July 2001
Current measurements within the electrospray emitter Pozniak, Boguslaw P.; Cole, Richard B. Journal of the American Society for Mass Spectrometry, Vol. 18, Issue 4 https://doi.org/10.1016/j.jasms.2006.11.012	journal	April 2007
A novel cold plasma jet generated by atmospheric dielectric barrier capillary discharge Zhang, Jialiang; Sun, Jiao; Wang, Dezhen Thin Solid Films, Vol. 506-507, p. 404-408 https://doi.org/10.1016/j.tsf.2005.08.088	journal	May 2006
Extractive electrospray ionization for direct analysis of undiluted urine, milk and other complex mixtures without sample preparation Chen, Huanwen; Venter, Andre; Cooks, R. Graham Chemical Communications, Issue 19 https://doi.org/10.1039/b602614a	journal	January 2006
Soft Landing of Complex Molecules on Surfaces Johnson, Grant E.; Hu, Qichi; Laskin, Julia Annual Review of Analytical Chemistry, Vol. 4, Issue 1, p. 83-104 https://doi.org/10.1146/annurev-anchem-061010-114028	journal	July 2011
Microfluidic capture and release of bacteria in a conical nanopore array Guo, Peng; Hall, Eric W.; Schirhagl, Romana Lab Chip, Vol. 12, Issue 3 https://doi.org/10.1039/C2LC21092D	journal	January 2012
Handheld Miniature Ion Trap Mass Spectrometers Ouyang, Zheng; Noll, Robert J.; Cooks, R. Graham Analytical Chemistry, Vol. 81, Issue 7 https://doi.org/10.1021/ac900292w	journal	March 2009
In situ generation of copper cations and complexation with tebuconazole in a hyphenation of electrochemistry with mass spectrometry Jaklová Dytrtová, Jana; Jakl, Michal; Schröder, Detlef International Journal of Mass Spectrometry, Vol. 338 https://doi.org/10.1016/j.ijms.2013.01.005	journal	March 2013
Surface Acoustic Wave Nebulization Facilitating Lipid Mass Spectrometric Analysis Yoon, Sung Hwan; Huang, Yue; Edgar, J. Scott Analytical Chemistry, Vol. 84, Issue 15 https://doi.org/10.1021/ac300807p	journal	July 2012
Nucleophilic Addition of Nitrogen to Aryl Cations: Mimicking Titan Chemistry Li, Anyin; Jjunju, Fred P. M.; Cooks, R. Graham Journal of The American Society for Mass Spectrometry, Vol. 24, Issue 11 https://doi.org/10.1007/s13361-013-0710-1	journal	August 2013
Inkjet-Printed Microfluidic Multianalyte Chemical Sensing Paper Abe, Koji; Suzuki, Koji; Citterio, Daniel Analytical Chemistry, Vol. 80, Issue 18, p. 6928-6934 https://doi.org/10.1021/ac800604v	journal	September 2008
On the evaporation of small ions from charged droplets Iribarne, J. V. The Journal of Chemical Physics, Vol. 64, Issue 6 https://doi.org/10.1063/1.432536	journal	January 1976
Enhancement of the performance of organic solar cells by electrospray deposition with optimal solvent system Zhao, Xin-Yan; Wang, Xizu; Lim, Siew Lay Solar Energy Materials and Solar Cells, Vol. 121 https://doi.org/10.1016/j.solmat.2013.10.020	journal	February 2014
The Electrical Discharge from Liquid Points, and a Hydrostatic Method of Measuring the Electric Intensity at Their Surfaces Zeleny, John Physical Review, Vol. 3, Issue 2 https://doi.org/10.1103/PhysRev.3.69	journal	February 1914
Low-Cost Printing of Poly(dimethylsiloxane) Barriers To Define Microchannels in Paper Bruzewicz, Derek A.; Reches, Meital; Whitesides, George M. Analytical Chemistry, Vol. 80, Issue 9, p. 3387-3392 https://doi.org/10.1021/ac702605a	journal	May 2008
Handheld Rectilinear Ion Trap Mass Spectrometer Gao, Liang; Song, Qingyu; Patterson, Garth E. Analytical Chemistry, Vol. 78, Issue 17, p. 5994-6002 https://doi.org/10.1021/ac061144k	journal	September 2006
Using Laser-Induced Acoustic Desorption/Electrospray Ionization Mass Spectrometry To Characterize Small Organic and Large Biological Compounds in the Solid State and in Solution Under Ambient Conditions Cheng, Sy-Chyi; Cheng, Tain-Lu; Chang, Hui-Chiu Analytical Chemistry, Vol. 81, Issue 3 https://doi.org/10.1021/ac800896y	journal	February 2009
Shiga-Like Toxin II Derived from Escherichia coli O157:H7 Modifies Renal Handling of Levofloxacin in Rats Zhao, Ying Lan; Cen, Xiao Bo; Ito, Masafumi Antimicrobial Agents and Chemotherapy, Vol. 46, Issue 5 https://doi.org/10.1128/AAC.46.5.1522-1528.2002	journal	May 2002
Nano-electrospray ionization mass spectrometry: addressing analytical problems beyond routine Karas, M.; Bahr, U.; Dülcks, T. Fresenius' Journal of Analytical Chemistry, Vol. 366, Issue 6-7, p. 669-676 https://doi.org/10.1007/s002160051561	journal	March 2000
Miniaturization and Geometry Optimization of a Polymer-Based Rectilinear Ion Trap Fico, Miriam; Yu, Meng; Ouyang, Zheng Analytical Chemistry, Vol. 79, Issue 21 https://doi.org/10.1021/ac0711384	journal	October 2007
Affecting Protein Charge State Distributions in Nano-Electrospray Ionization via In-Spray Solution Mixing Using Theta Capillaries Fisher, Christine M.; Kharlamova, Anastasia; McLuckey, Scott A. Analytical Chemistry, Vol. 86, Issue 9 https://doi.org/10.1021/ac500721r	journal	April 2014
Multiplexed extraction and quantitative analysis of pharmaceuticals from DBS samples using digital microfluidics Lafrenière, Nelson M.; Shih, Steve CC; Abu-Rabie, Paul Bioanalysis, Vol. 6, Issue 3 https://doi.org/10.4155/bio.13.311	journal	February 2014
Molecular Beams of Macroions. II Mack, L. L.; Kralik, P.; Rheude, A. The Journal of Chemical Physics, Vol. 52, Issue 10 https://doi.org/10.1063/1.1672733	journal	May 1970
Hand-Held Mass Spectrometer for Environmentally Relevant Analytes Using a Variety of Sampling and Ionization Methods Sanders, Nathaniel L.; Sokol, Ewa; Perry, Richard H. European Journal of Mass Spectrometry, Vol. 16, Issue 1 https://doi.org/10.1255/ejms.1036	journal	February 2010
Enhanced silver cationization of polycyclic aromatic hydrocarbons containing bay regions in molecular secondary ion mass spectrometry Hand, Owen W.; Winger, Brian E.; Cooks, R. Graham Biological Mass Spectrometry, Vol. 18, Issue 1 https://doi.org/10.1002/bms.1200180112	journal	January 1989
Laser Ablation Electrospray Ionization for Atmospheric Pressure, in Vivo, and Imaging Mass Spectrometry Nemes, Peter; Vertes, Akos Analytical Chemistry, Vol. 79, Issue 21 https://doi.org/10.1021/ac071181r	journal	November 2007
Paper Spray for Direct Analysis of Complex Mixtures Using Mass Spectrometry Wang, He; Liu, Jiangjiang; Cooks, R. Graham Angewandte Chemie, Vol. 122, Issue 5, p. 889-892 https://doi.org/10.1002/ange.200906314	journal	January 2010
Profiling pH Gradients Across Nanocapillary Array Membranes Connecting Microfluidic Channels Fa, Keqing; Tulock, Joseph J.; Sweedler, Jonathan V. Journal of the American Chemical Society, Vol. 127, Issue 40 https://doi.org/10.1021/ja052708p	journal	October 2005
Characterization of dielectric barrier electrospray ionization for mass spectrometric detection Stark, Ann Kathrin; Schilling, Michael; Janasek, Dirk Analytical and Bioanalytical Chemistry, Vol. 397, Issue 5 https://doi.org/10.1007/s00216-010-3749-x	journal	May 2010

Similar Records

Systems and methods for relay ionization

Patent · 2019 · OSTI ID:1568123

Systems and methods for relay ionization

Patent · 2019 · OSTI ID:1576420

Sample analysis systems and methods of use thereof

Patent · 2020 · OSTI ID:1735056

Related Subjects

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY

Systems and methods for relay ionization

Citation Formats

References (66)

Similar Records

Related Subjects