skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Extraction chromatography of 225Ac and lanthanides on N,N-dioctyldiglycolamic acid /1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide solvent impregnated resin

Abstract

The alpha-emitter 225Ac (t1/2 = 9.92 d) is currently under development for targeted alpha-particle therapy of cancer, and accelerator production of 225Ac via proton irradiation of thorium targets requires robust separations of 225Ac from chemically similar fission product lanthanides. Additionally, the lanthanide elements represent critical components in modern technologies, and radiolanthanides such as 140Nd (t1/2 = 3.37 d) also have potential application in the field of nuclear medicine. The ionic liquid, 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([Bmim][NTf2]), combined with the diglycolamide extractant, N,N-dioctyldiglycolamic acid (DODGAA), was adsorbed on macroporous resin support to produce a solvent impregnated resin (SIR) that was investigated for separations of 225Ac and lanthanides. The equilibrium distribution coefficients (Kd) of the rare earth elements (Sc(III), Y(III), Ln(III)), 225Ac(III), Th(IV), and U(VI) on the prepared DODGAA/[Bmim][NTf2]-SIR were determined from batch adsorption experiments in HCl and HNO3 media. The DODGAA/[Bmim][NTf2]-SIR exhibited preferential uptake of the heavier lanthanide elements while allowing for the separation of the lighter lanthanides. Column separations utilizing the DODGAA/[Bmim][NTf2]-SIR were effective at separating the lighter lanthanides from each other, and separating 225Ac from a mixture of lanthanides, 213Bi, and 225Ra without the need for additional complexing agents.

Authors:
ORCiD logo [1];  [1]; ORCiD logo [2]; ORCiD logo [1];  [1]; ORCiD logo [1]; ORCiD logo [1]
  1. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  2. Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Univ. of Utah, Salt Lake City, UT (United States)
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE Office of Science (SC). Nuclear Physics (NP) (SC-26); USDOE
OSTI Identifier:
1631575
Alternate Identifier(s):
OSTI ID: 1775849
Report Number(s):
LA-UR-20-21569
Journal ID: ISSN 0021-9673
Grant/Contract Number:  
89233218CNA000001
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Journal of Chromatography
Additional Journal Information:
Journal Volume: 1624; Journal Issue: C; Journal ID: ISSN 0021-9673
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Friend, Mitchell Thomas, Parker, Tracey Gannon, Mastren, Tara, Mocko, Veronika, Brugh, Mark, Birnbaum, Eva R., and Fassbender, Michael Ernst. Extraction chromatography of 225Ac and lanthanides on N,N-dioctyldiglycolamic acid /1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide solvent impregnated resin. United States: N. p., 2020. Web. doi:10.1016/j.chroma.2020.461219.
Friend, Mitchell Thomas, Parker, Tracey Gannon, Mastren, Tara, Mocko, Veronika, Brugh, Mark, Birnbaum, Eva R., & Fassbender, Michael Ernst. Extraction chromatography of 225Ac and lanthanides on N,N-dioctyldiglycolamic acid /1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide solvent impregnated resin. United States. https://doi.org/10.1016/j.chroma.2020.461219
Friend, Mitchell Thomas, Parker, Tracey Gannon, Mastren, Tara, Mocko, Veronika, Brugh, Mark, Birnbaum, Eva R., and Fassbender, Michael Ernst. 2020. "Extraction chromatography of 225Ac and lanthanides on N,N-dioctyldiglycolamic acid /1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide solvent impregnated resin". United States. https://doi.org/10.1016/j.chroma.2020.461219. https://www.osti.gov/servlets/purl/1631575.
@article{osti_1631575,
title = {Extraction chromatography of 225Ac and lanthanides on N,N-dioctyldiglycolamic acid /1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide solvent impregnated resin},
author = {Friend, Mitchell Thomas and Parker, Tracey Gannon and Mastren, Tara and Mocko, Veronika and Brugh, Mark and Birnbaum, Eva R. and Fassbender, Michael Ernst},
abstractNote = {The alpha-emitter 225Ac (t1/2 = 9.92 d) is currently under development for targeted alpha-particle therapy of cancer, and accelerator production of 225Ac via proton irradiation of thorium targets requires robust separations of 225Ac from chemically similar fission product lanthanides. Additionally, the lanthanide elements represent critical components in modern technologies, and radiolanthanides such as 140Nd (t1/2 = 3.37 d) also have potential application in the field of nuclear medicine. The ionic liquid, 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([Bmim][NTf2]), combined with the diglycolamide extractant, N,N-dioctyldiglycolamic acid (DODGAA), was adsorbed on macroporous resin support to produce a solvent impregnated resin (SIR) that was investigated for separations of 225Ac and lanthanides. The equilibrium distribution coefficients (Kd) of the rare earth elements (Sc(III), Y(III), Ln(III)), 225Ac(III), Th(IV), and U(VI) on the prepared DODGAA/[Bmim][NTf2]-SIR were determined from batch adsorption experiments in HCl and HNO3 media. The DODGAA/[Bmim][NTf2]-SIR exhibited preferential uptake of the heavier lanthanide elements while allowing for the separation of the lighter lanthanides. Column separations utilizing the DODGAA/[Bmim][NTf2]-SIR were effective at separating the lighter lanthanides from each other, and separating 225Ac from a mixture of lanthanides, 213Bi, and 225Ra without the need for additional complexing agents.},
doi = {10.1016/j.chroma.2020.461219},
url = {https://www.osti.gov/biblio/1631575}, journal = {Journal of Chromatography},
issn = {0021-9673},
number = C,
volume = 1624,
place = {United States},
year = {Sat May 23 00:00:00 EDT 2020},
month = {Sat May 23 00:00:00 EDT 2020}
}

Journal Article:

Citation Metrics:
Cited by: 10 works
Citation information provided by
Web of Science

Save / Share:

Works referenced in this record:

An Overview of Targeted Alpha Therapy with 225 Actinium and 213 Bismuth
journal, October 2018


Production of Ac-225 from Th-229 for Targeted α Therapy
journal, October 2005


Therapeutic Radionuclides: Biophysical and Radiobiologic Principles
journal, September 2008


Alpha-Emitters and Targeted Alpha Therapy in Oncology: from Basic Science to Clinical Investigations
journal, February 2018


Present and Future Prospects of Radiation Therapy Using α-Emitting Nuclides
journal, January 2018


225Ac-PSMA-617 for PSMA-Targeted  -Radiation Therapy of Metastatic Castration-Resistant Prostate Cancer
journal, July 2016


Production of actinium-225 for alpha particle mediated radioimmunotherapy
journal, May 2005


Ac, La, and Ce radioimpurities in 225Ac produced in 40–200 MeV proton irradiations of thorium
journal, January 2014


Proton-induced cross sections relevant to production of 225Ac and 223Ra in natural thorium targets below 200MeV
journal, November 2012


Large scale accelerator production of 225Ac: Effective cross sections for 78–192 MeV protons incident on 232Th targets
journal, December 2016


An Improved Method for the Production of Ac‐225/Bi‐213 from Th‐229 for Targeted Alpha Therapy
journal, April 2007


Benefiting from the Unique Properties of Lanthanide Ions
journal, January 2006


Lanthanide-Based Luminescent Hybrid Materials
journal, September 2009


Nuclear forensic analysis of an unknown uranium ore concentrate sample seized in a criminal investigation in Australia
journal, July 2014


Application of radioisotopes in the field of nuclear medicine: I. Lanthanide series elements
journal, November 1999


Extraction of Rare Earths in Ionic Liquids Via Competitive Ligand Complexation between TODGA and DTPA
journal, September 2018


Solvent-impregnated resins (SIRs) – Methods of preparation and their applications
journal, August 2010


Use of extraction chromatography in the recycling of critical metals from thin film leach solutions
journal, March 2017


Solvent extraction-separation of La(III), Eu(III) and Er(III) ions from aqueous chloride medium using carbamoyl-carboxylic acid extractants
journal, January 2016


Synthesis and Characterization of the Actinium Aquo Ion
journal, February 2017


Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides
journal, September 1976


Production and Radiochemical Separation of the Auger Electron Emitter 140 Nd
journal, January 2000


Determination of the age of highly enriched uranium
journal, October 2002


A method for dating small amounts of uranium
journal, September 2012