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Title: Efficacy of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine in cattle using a direct contact transmission model

Abstract

A direct contact transmission challenge model was used to simulate natural foot-and-mouth disease virus (FMDV) spread from FMDV A24/Cruzeiro/BRA/55 infected ‘seeder’ steers to naïve or vaccinated steers previously immunized with a replication-deficient human adenovirus-vectored FMDV A24/Cruzeiro/BRA/55 capsid-based subunit vaccine (AdtA24). In two independent vaccine efficacy trials, AdtA24 was administered once intramuscularly in the neck 7 days prior to contact with FMDV A24/Cruzeiro/BRA/55-infected seeder steers.

Authors:
ORCiD logo; ; ; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Oak Ridge Associated Univ., Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1618781
Alternate Identifier(s):
OSTI ID: 1626876
Grant/Contract Number:  
number DE-AC05-06OR23100; AC05-06OR23100
Resource Type:
Journal Article: Published Article
Journal Name:
BMC Veterinary Research
Additional Journal Information:
Journal Name: BMC Veterinary Research Journal Volume: 14 Journal Issue: 1; Journal ID: ISSN 1746-6148
Publisher:
Springer Science + Business Media
Country of Publication:
United Kingdom
Language:
English
Subject:
Veterinary Sciences; foot-and-mouth disease virus; FMDV A24/Cruzeiro/BRA/55; Replication-deficient human adenovirusvectored vaccine; DIVA; Vaccine efficacy

Citation Formats

Neilan, John G., Schutta, Christopher, Barrera, José, Pisano, Melia, Zsak, Laszlo, Hartwig, Ethan, Rasmussen, Max V., Kamicker, Barbara J., Ettyreddy, Damodar, Brough, Douglas E., Butman, Bryan T., and Brake, David A. Efficacy of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine in cattle using a direct contact transmission model. United Kingdom: N. p., 2018. Web. doi:10.1186/s12917-018-1582-1.
Neilan, John G., Schutta, Christopher, Barrera, José, Pisano, Melia, Zsak, Laszlo, Hartwig, Ethan, Rasmussen, Max V., Kamicker, Barbara J., Ettyreddy, Damodar, Brough, Douglas E., Butman, Bryan T., & Brake, David A. Efficacy of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine in cattle using a direct contact transmission model. United Kingdom. https://doi.org/10.1186/s12917-018-1582-1
Neilan, John G., Schutta, Christopher, Barrera, José, Pisano, Melia, Zsak, Laszlo, Hartwig, Ethan, Rasmussen, Max V., Kamicker, Barbara J., Ettyreddy, Damodar, Brough, Douglas E., Butman, Bryan T., and Brake, David A. Wed . "Efficacy of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine in cattle using a direct contact transmission model". United Kingdom. https://doi.org/10.1186/s12917-018-1582-1.
@article{osti_1618781,
title = {Efficacy of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine in cattle using a direct contact transmission model},
author = {Neilan, John G. and Schutta, Christopher and Barrera, José and Pisano, Melia and Zsak, Laszlo and Hartwig, Ethan and Rasmussen, Max V. and Kamicker, Barbara J. and Ettyreddy, Damodar and Brough, Douglas E. and Butman, Bryan T. and Brake, David A.},
abstractNote = {A direct contact transmission challenge model was used to simulate natural foot-and-mouth disease virus (FMDV) spread from FMDV A24/Cruzeiro/BRA/55 infected ‘seeder’ steers to naïve or vaccinated steers previously immunized with a replication-deficient human adenovirus-vectored FMDV A24/Cruzeiro/BRA/55 capsid-based subunit vaccine (AdtA24). In two independent vaccine efficacy trials, AdtA24 was administered once intramuscularly in the neck 7 days prior to contact with FMDV A24/Cruzeiro/BRA/55-infected seeder steers.},
doi = {10.1186/s12917-018-1582-1},
url = {https://www.osti.gov/biblio/1618781}, journal = {BMC Veterinary Research},
issn = {1746-6148},
number = 1,
volume = 14,
place = {United Kingdom},
year = {2018},
month = {8}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record at https://doi.org/10.1186/s12917-018-1582-1

Citation Metrics:
Cited by: 2 works
Citation information provided by
Web of Science

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Works referenced in this record:

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