C–H 18F-fluorination of 8-methylquinolines with Ag[18F]F
- Univ. of Michigan, Ann Arbor, MI (United States). Dept. of Radiology
- Univ. of Michigan, Ann Arbor, MI (United States). Dept. of Chemistry
This report describes a Pd-mediated C–H radiofluorination of 8-methylquinoline derivatives with no-carrier-added Ag[18F]F. To achieve this transformation, a new method was developed for the generation of Ag[18F]F using a sep-pak cartridge. The C–H radiofluorination was then optimized and applied to a series of substituted 8-methylquinoline derivatives. Finally, this method was fully automated using a radiochemistry synthesis module.
- Research Organization:
- Univ. of Michigan, Ann Arbor, MI (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- Grant/Contract Number:
- SC0012484
- OSTI ID:
- 1611829
- Alternate ID(s):
- OSTI ID: 1495071
- Journal Information:
- ChemComm, Vol. 55, Issue 20; ISSN 1359-7345
- Publisher:
- Royal Society of ChemistryCopyright Statement
- Country of Publication:
- United States
- Language:
- English
Cited by: 14 works
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