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Mitochondrial complex III Q i -site inhibitor resistance mutations found in laboratory selected mutants and field isolates: Target site QiI resistance mutations

Journal Article · · Pest Management Science
DOI:https://doi.org/10.1002/ps.5264· OSTI ID:1610935
 [1];  [1];  [1];  [2];  [2];  [3];  [1]
  1. Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette France
  2. Institut de Chimie des Substances Naturelles, CNRS, UPR 2301, Université Paris-Saclay, Labex LERMIT, Gif-sur-Yvette France
  3. MSU-DOE Plant Research Laboratory, Michigan State University, East Lansing Michigan USA
+ Show Author Affiliations

Not provided.

Research Organization:
Michigan State Univ., East Lansing, MI (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
DOE Contract Number:
SC0007101
OSTI ID:
1610935
Journal Information:
Pest Management Science, Vol. 75, Issue 8; ISSN 1526-498X
Publisher:
Wiley
Country of Publication:
United States
Language:
English

References (33)

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The Biochemical Mode of Action of the Novel Selective Fungicide Cyazofamid: Specific Inhibition of Mitochondrial Complex III in Phythium spinosum October 2001
Subtle Changes in Endochin-Like Quinolone Structure Alter the Site of Inhibition within the Cytochrome bc 1 Complex of Plasmodium falciparum January 2015
Clinical atovaquone-proguanil resistance of Plasmodium falciparum associated with cytochrome b codon 268 mutations September 2006
Crystallographic Studies of Quinol Oxidation Site Inhibitors: A Modified Classification of Inhibitors for the Cytochrome bc 1 Complex July 2004
Binding of the respiratory chain inhibitor ametoctradin to the mitochondrial bc 1 complex: Binding of Ametoctradin to mitochondrial bc 1 complex May 2015
Diversity-Oriented Synthesis Probe Targets Plasmodium falciparum Cytochrome b Ubiquinone Reduction Site and Synergizes With Oxidation Site Inhibitors October 2014
The strobilurin fungicides January 2002
HDQ, a Potent Inhibitor of Plasmodium falciparum Proliferation, Binds to the Quinone Reduction Site of the Cytochrome bc 1 Complex April 2012
Human Disease-related Mutations in Cytochrome b Studied in Yeast January 2004
Structural Basis for the Quinone Reduction in the bc 1 Complex:  A Comparative Analysis of Crystal Structures of Mitochondrial Cytochrome bc 1 with Bound Substrate and Inhibitors at the Q i Site † , ‡ August 2003
Comparative Kinetics of Q i Site Inhibitors of Cytochrome bc 1 Complex: Picomolar Antimycin and Micromolar Cyazofamid September 2013
Analysis of revertants from respiratory deficient mutants within the center N of cytochrome b in Saccharomyces cerevisiae February 1994
Characterization of the mechanism of action of the fungicide fenpicoxamid and its metabolite UK-2A: Mechanism of action of fenpicoxamid November 2017
Differential efficacy of inhibition of mitochondrial and bacterial cytochrome bc1 complexes by center N inhibitors antimycin, ilicicolin H and funiculosin February 2008
Antimycin A resistance in a mutant Leishmania tarentolae strain is correlated to a point mutation in the mitochondrial apocytochrome b gene April 2000
The antimalarial compound ELQ ‐400 is an unusual inhibitor of the bc 1 complex, targeting both Q o and Q i sites December 2017
Emergence of Resistance to Atovaquone-Proguanil in Malaria Parasites: Insights from Computational Modeling and Clinical Case Reports May 2014
Investigating the Q n Site of the Cytochrome bc 1 Complex in Saccharomyces cerevisiae with Mutants Resistant to Ilicicolin H, a Novel Q n Site Inhibitor September 2006
Improved protein-ligand docking using GOLD August 2003
Two changes of the same nucleotide confer resistance to diuron and antimycin in the mitochondrial cytochrome b gene of Schizosaccharomyces pombe September 1988
Recapitulation in Saccharomyces cerevisiae of Cytochrome b Mutations Conferring Resistance to Atovaquone in Pneumocystis jiroveci August 2003
Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis September 2012
Characterization of Mutations in the Mitochondrial Cytochrome b Gene of Saccharomyces Cerevisiae Affecting the Quinone Reductase Site (QN) June 1995
The cytochrome bc complex inhibitor Ametoctradin has an unusual binding mode August 2018
Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease July 2015
Mitochondrial cytochrome b genes with a six-nucleotide deletion or single-nucleotide substitutions confer resistance to antimycin A in the yeast Kluyveromyces lactis November 1989
Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action June 2014
Mutational analysis of the mouse mitochondrial cytochrome b gene October 1988
UCSF Chimera?A visualization system for exploratory research and analysis January 2004
Isolation and RNA sequence analysis of cytochrome b mutants resistant to funiculosin, a center i inhibitor of the mitochondrial ubiquinol-cytochrome c reductase in Saccharomyces cerevisiae April 1990
Human Mitochondrial Cytochrome b Variants Studied in Yeast: Not All Are Silent Polymorphisms June 2016
DNA sequence analysis of diuron-resistant mutations in the mitochondrial cytochrome b gene of Saccharomyces cerevisiae November 1986

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