Temporospatial shifts in the human gut microbiome and metabolome after gastric bypass surgery

Ilhan, Zehra E.; DiBaise, John K.; Dautel, Sydney E.; Isern, Nancy G.; Kim, Young-Mo; Hoyt, David W.; Schepmoes, Athena A.; Brewer, Heather M.; Weitz, Karl K.; Metz, Thomas O.; Crowell, Michael; Kang, Dae Wook; Rittmann, Bruce E.; Krajmalnik-Brown, Rosa

doi:10.1038/s41522-020-0122-5

Title: Temporospatial shifts in the human gut microbiome and metabolome after gastric bypass surgery

Journal Article · Fri Mar 13 00:00:00 EDT 2020 · npj Biofilms and Microbiomes

DOI:https://doi.org/10.1038/s41522-020-0122-5· OSTI ID:1607642

Ilhan, Zehra E. ^[1]; DiBaise, John K. ^[2]; Dautel, Sydney E. ^[3]; Isern, Nancy G. ^[3];

^[4];

^[3]; Schepmoes, Athena A. ^[4];

^[3]; Weitz, Karl K. ^[4];

^[4]; Crowell, Michael ^[2]; Kang, Dae Wook ^[1]; Rittmann, Bruce E. ^[1]; Krajmalnik-Brown, Rosa ^[1]

Arizona State Univ., Tempe, AZ (United States)
Mayo Clinic, Scottsdale, AZ (United States). Division of Gastroenterology
Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Although the etiology of obesity is not well-understood, genetic, environmental, and microbiome elements are recognized as contributors to this rising pandemic. For morbid obesity, Roux-en-Y gastric bypass (RYGB) surgery alters the fecal microbiome, but data are sparse on temporal and spatial changes in the microbiome and metabolome. We characterized the structure and metabolism of the microbial communities in the gut lumen and on mucosal surfaces in morbidly obese individuals before and after RYGB surgery, and we compared our longitudinal cohort to a previously studied cross-sectional one. RYGB concurrently changed the gut microbiome and led to improvements of obesity comorbidities. Changes in the gut microbiome were reflected in the metabolome, including fermentation products and bile acids. The effects persisted 12 months post-surgery, and the microbiomes and metabolomes were similar to those found for the cross-sectional RYGB cohort. Thus, RYGB surgery had profound and persistent impacts on the intestinal microbiome and metabolome.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1607642

Report Number(s):: PNNL-SA-133750

Journal Information:: npj Biofilms and Microbiomes, Vol. 6, Issue 1; ISSN 2055-5008

Publisher:: Springer NatureCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 36 works

Citation information provided by
Web of Science

References (74)

PYY plays a key role in the resolution of diabetes following bariatric surgery in humans Guida, Claudia; Stephen, Sam D.; Watson, Michael EBioMedicine, Vol. 40 https://doi.org/10.1016/j.ebiom.2018.12.040	journal	February 2019
Human gut microbiota in obesity and after gastric bypass Zhang, H.; DiBaise, J. K.; Zuccolo, A. Proceedings of the National Academy of Sciences, Vol. 106, Issue 7 https://doi.org/10.1073/pnas.0812600106	journal	January 2009
Role of oxygen gradients in shaping redox relationships between the human intestine and its microbiota Espey, Michael Graham Free Radical Biology and Medicine, Vol. 55 https://doi.org/10.1016/j.freeradbiomed.2012.10.554	journal	February 2013
ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap Metsalu, Tauno; Vilo, Jaak Nucleic Acids Research, Vol. 43, Issue W1 https://doi.org/10.1093/nar/gkv468	journal	May 2015
Energy intake is associated with endotoxemia in apparently healthy men Amar, Jacques; Burcelin, Rémy; Ruidavets, Jean Bernard The American Journal of Clinical Nutrition, Vol. 87, Issue 5 https://doi.org/10.1093/ajcn/87.5.1219	journal	May 2008
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences Langille, Morgan G. I.; Zaneveld, Jesse; Caporaso, J. Gregory Nature Biotechnology, Vol. 31, Issue 9 https://doi.org/10.1038/nbt.2676	journal	August 2013
Preoperative Weight Loss Before Bariatric Surgery Benotti, Peter N. Archives of Surgery, Vol. 144, Issue 12 https://doi.org/10.1001/archsurg.2009.209	journal	December 2009
Distinctive microbiomes and metabolites linked with weight loss after gastric bypass, but not gastric banding Ilhan, Zehra Esra; DiBaise, John K.; Isern, Nancy G. The ISME Journal, Vol. 11, Issue 9 https://doi.org/10.1038/ismej.2017.71	journal	May 2017
The Impact of Preoperative Weight Loss in Patients Undergoing Laparoscopic Roux-en-Y Gastric Bypass Alvarado, R.; Alami, R. S.; Hsu, G. Obesity Surgery, Vol. 15, Issue 9 https://doi.org/10.1381/096089205774512429	journal	October 2005
PANDAseq: paired-end assembler for illumina sequences Masella, Andre P.; Bartram, Andrea K.; Truszkowski, Jakub M. BMC Bioinformatics, Vol. 13, Issue 1 https://doi.org/10.1186/1471-2105-13-31	journal	January 2012
Optimal sampling of the intestinal microbiota for research Sartor, R. Balfour Nature Reviews Gastroenterology & Hepatology, Vol. 12, Issue 5 https://doi.org/10.1038/nrgastro.2015.46	journal	March 2015
Bile acids and the gut microbiome Ridlon, Jason M.; Kang, Dae J.; Hylemon, Phillip B. Current Opinion in Gastroenterology, Vol. 30, Issue 3 https://doi.org/10.1097/MOG.0000000000000057	journal	January 2014
Influence of early life exposure, host genetics and diet on the mouse gut microbiome and metabolome Snijders, Antoine M.; Langley, Sasha A.; Kim, Young-Mo Nature Microbiology, Vol. 2, Issue 2 https://doi.org/10.1038/nmicrobiol.2016.221	journal	November 2016
A Surgical Model in Male Obese Rats Uncovers Protective Effects of Bile Acids Post-Bariatric Surgery Kohli, Rohit; Setchell, Kenneth DR; Kirby, Michelle Endocrinology, Vol. 154, Issue 7 https://doi.org/10.1210/en.2012-2069	journal	July 2013
Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist Sayin, Sama I.; Wahlström, Annika; Felin, Jenny Cell Metabolism, Vol. 17, Issue 2 https://doi.org/10.1016/j.cmet.2013.01.003	journal	February 2013
Differential Adaptation of Human Gut Microbiota to Bariatric Surgery-Induced Weight Loss: Links With Metabolic and Low-Grade Inflammation Markers Furet, J. -P.; Kong, L. -C.; Tap, J. Diabetes, Vol. 59, Issue 12 https://doi.org/10.2337/db10-0253	journal	September 2010
H OW H OST -M ICROBIAL I NTERACTIONS S HAPE THE N UTRIENT E NVIRONMENT OF THE M AMMALIAN I NTESTINE Hooper, Lora V.; Midtvedt, Tore; Gordon, Jeffrey I. Annual Review of Nutrition, Vol. 22, Issue 1 https://doi.org/10.1146/annurev.nutr.22.011602.092259	journal	July 2002
The Earth Microbiome project: successes and aspirations Gilbert, Jack A.; Jansson, Janet K.; Knight, Rob BMC Biology, Vol. 12, Issue 1 https://doi.org/10.1186/s12915-014-0069-1	journal	August 2014
Increase in fecal primary bile acids and dysbiosis in patients with diarrhea-predominant irritable bowel syndrome: Bile acids and dysbiosis in IBS-D patients Duboc, H.; Rainteau, D.; Rajca, S. Neurogastroenterology & Motility, Vol. 24, Issue 6 https://doi.org/10.1111/j.1365-2982.2012.01893.x	journal	February 2012
Bile acid profiling in human biological samples: Comparison of extraction procedures and application to normal and cholestatic patients Humbert, Lydie; Maubert, Marie Anne; Wolf, Claude Journal of Chromatography B, Vol. 899 https://doi.org/10.1016/j.jchromb.2012.05.015	journal	June 2012
Human Intestinal Lumen and Mucosa-Associated Microbiota in Patients with Colorectal Cancer Chen, Weiguang; Liu, Fanlong; Ling, Zongxin PLoS ONE, Vol. 7, Issue 6 https://doi.org/10.1371/journal.pone.0039743	journal	June 2012
FXR is a molecular target for the effects of vertical sleeve gastrectomy Ryan, Karen K.; Tremaroli, Valentina; Clemmensen, Christoffer Nature, Vol. 509, Issue 7499 https://doi.org/10.1038/nature13135	journal	March 2014
Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology Dao, Maria Carlota; Everard, Amandine; Aron-Wisnewsky, Judith Gut, Vol. 65, Issue 3 https://doi.org/10.1136/gutjnl-2014-308778	journal	June 2015
Duodenal Mucosa of Patients With Type 1 Diabetes Shows Distinctive Inflammatory Profile and Microbiota Pellegrini, Silvia; Sordi, Valeria; Bolla, Andrea Mario The Journal of Clinical Endocrinology & Metabolism, Vol. 102, Issue 5 https://doi.org/10.1210/jc.2016-3222	journal	January 2017
Conservation evaluation and phylogenetic diversity Faith, Daniel P. Biological Conservation, Vol. 61, Issue 1 https://doi.org/10.1016/0006-3207(92)91201-3	journal	January 1992
Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass Korner, J.; Inabnet, W.; Febres, G. International Journal of Obesity, Vol. 33, Issue 7 https://doi.org/10.1038/ijo.2009.79	journal	May 2009
The Impact of Diet and Lifestyle on Gut Microbiota and Human Health Conlon, Michael; Bird, Anthony Nutrients, Vol. 7, Issue 1 https://doi.org/10.3390/nu7010017	journal	December 2014
Treatment With Ursodeoxycholic Acid Is Associated With Weight Gain in Patients With Primary Biliary Cirrhosis Siegel, Joanna L.; Jorgensen, Roberta; Angulo, Paul Journal of Clinical Gastroenterology, Vol. 37, Issue 2 https://doi.org/10.1097/00004836-200308000-00018	journal	January 2003
Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk Li, J. V.; Ashrafian, H.; Bueter, M. Gut, Vol. 60, Issue 9 https://doi.org/10.1136/gut.2010.234708	journal	May 2011
O27 Adaptation du Microbiote intestinal après la perte du poids : Effets du bypass gastrique (GBP) chez les sujets massivement obèses Kong, L. C.; Furet, J. P.; Tap, J. Diabetes & Metabolism, Vol. 36 https://doi.org/10.1016/S1262-3636(10)70031-8	journal	March 2010
Assessment of bacterial diversity in breast milk using culture-dependent and culture-independent approaches Jost, Ted; Lacroix, Christophe; Braegger, Christian British Journal of Nutrition, Vol. 110, Issue 7 https://doi.org/10.1017/S0007114513000597	journal	March 2013
A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance Newgard, Christopher B.; An, Jie; Bain, James R. Cell Metabolism, Vol. 9, Issue 4 https://doi.org/10.1016/j.cmet.2009.02.002	journal	April 2009
Effects of bariatric surgery on disability pension in Swedish obese subjects Gripeteg, L.; Lindroos, A. K.; Peltonen, M. International Journal of Obesity, Vol. 36, Issue 3 https://doi.org/10.1038/ijo.2011.15	journal	March 2011
Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery Flynn, Charles Robb; Albaugh, Vance L.; Cai, Steven Nature Communications, Vol. 6, Issue 1 https://doi.org/10.1038/ncomms8715	journal	July 2015
Conserved Shifts in the Gut Microbiota Due to Gastric Bypass Reduce Host Weight and Adiposity Liou, A. P.; Paziuk, M.; Luevano, J. -M. Science Translational Medicine, Vol. 5, Issue 178 https://doi.org/10.1126/scitranslmed.3005687	journal	March 2013
Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults Chambers, Edward S.; Viardot, Alexander; Psichas, Arianna Gut, Vol. 64, Issue 11 https://doi.org/10.1136/gutjnl-2014-307913	journal	December 2014
Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation Tremaroli, Valentina; Karlsson, Fredrik; Werling, Malin Cell Metabolism, Vol. 22, Issue 2 https://doi.org/10.1016/j.cmet.2015.07.009	journal	August 2015
Microbial biofilms in the human gastrointestinal tract Macfarlane, S.; Dillon, J. F. Journal of Applied Microbiology, Vol. 102, Issue 5 https://doi.org/10.1111/j.1365-2672.2007.03287.x	journal	May 2007
Akkermansia muciniphila abundance is lower in severe obesity, but its increased level after bariatric surgery is not associated with metabolic health improvement Dao, Maria Carlota; Belda, Eugeni; Prifti, Edi American Journal of Physiology-Endocrinology and Metabolism, Vol. 317, Issue 3 https://doi.org/10.1152/ajpendo.00140.2019	journal	September 2019
Major microbiota dysbiosis in severe obesity: fate after bariatric surgery Aron-Wisnewsky, Judith; Prifti, Edi; Belda, Eugeni Gut, Vol. 68, Issue 1 https://doi.org/10.1136/gutjnl-2018-316103	journal	June 2018
Protection and Restitution of Gut Barrier by Probiotics: Nutritional and Clinical Implications Krishna Rao, Radha; Samak, Geetha Current Nutrition & Food Science, Vol. 9, Issue 2 https://doi.org/10.2174/1573401311309020004	journal	April 2013
QIIME allows analysis of high-throughput community sequencing data Caporaso, J. Gregory; Kuczynski, Justin; Stombaugh, Jesse Nature Methods, Vol. 7, Issue 5 https://doi.org/10.1038/nmeth.f.303	journal	April 2010
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity Everard, A.; Belzer, C.; Geurts, L. Proceedings of the National Academy of Sciences, Vol. 110, Issue 22 https://doi.org/10.1073/pnas.1219451110	journal	May 2013
Fitting Multivariate Models to Community Data: a Comment on Distance-Based Redundancy Analysis McArdle, Brian H.; Anderson, Marti J. Ecology, Vol. 82, Issue 1 https://doi.org/10.1890/0012-9658(2001)082[0290:FMMTCD]2.0.CO;2	journal	January 2001
Assessing Gut Microbial Diversity from Feces and Rectal Mucosa Durbán, Ana; Abellán, Juan J.; Jiménez-Hernández, Nuria Microbial Ecology, Vol. 61, Issue 1 https://doi.org/10.1007/s00248-010-9738-y	journal	August 2010
Serum Bile Acids Are Higher in Humans With Prior Gastric Bypass: Potential Contribution to Improved Glucose and Lipid Metabolism Patti, Mary-Elizabeth; Houten, Sander M.; Bianco, Antonio C. Obesity, Vol. 17, Issue 9 https://doi.org/10.1038/oby.2009.102	journal	April 2009
Lactate is mainly fermented to butyrate by human intestinal microfloras but inter-individual variation is evident Bourriaud, C.; Robins, R. J.; Martin, L. Journal of Applied Microbiology, Vol. 99, Issue 1 https://doi.org/10.1111/j.1365-2672.2005.02605.x	journal	July 2005
Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms Lin, Hua V.; Frassetto, Andrea; Kowalik Jr, Edward J. PLoS ONE, Vol. 7, Issue 4 https://doi.org/10.1371/journal.pone.0035240	journal	April 2012
The activity of gastric ghrelin positive cells in obese patients treated surgically. Dadan, Jacek; Hady, Hady Razak; Zbucki, Robert Lukasz Folia Histochemica et Cytobiologica, Vol. 47, Issue 2 https://doi.org/10.2478/v10042-009-0033-z	journal	December 2009
Fecal bile acid profile after Roux-en-Y gastric bypass and its association with the remission of type 2 diabetes in obese women: A preliminary study de Siqueira Cardinelli, Camila; Torrinhas, Raquel Susana; Sala, Priscila Clinical Nutrition, Vol. 38, Issue 6 https://doi.org/10.1016/j.clnu.2018.12.028	journal	December 2019
Distinct patterns in the gut microbiota after surgical or medical therapy in obese patients Medina, Daniel A.; Pedreros, Juan P.; Turiel, Dannae PeerJ, Vol. 5 https://doi.org/10.7717/peerj.3443	journal	January 2017
Effect of Roux-en-Y Gastric Bypass Surgery on Bile Acid Metabolism in Normal and Obese Diabetic Rats Bhutta, Hina Y.; Rajpal, Neetu; White, Wendy PLOS ONE, Vol. 10, Issue 3 https://doi.org/10.1371/journal.pone.0122273	journal	March 2015
Metabolic syndrome remission after Roux-en-Y gastric bypass or sleeve gastrectomy Nassour, Ibrahim; Almandoz, Jaime; Adams-Huet, Beverley Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol. Volume 10 https://doi.org/10.2147/DMSO.S142731	journal	January 2017
The Role of Bile After Roux-en-Y Gastric Bypass in Promoting Weight Loss and Improving Glycaemic Control Pournaras, Dimitri J.; Glicksman, Clare; Vincent, Royce P. Endocrinology, Vol. 153, Issue 8 https://doi.org/10.1210/en.2011-2145	journal	August 2012
Impact of Laparoscopic Roux-en-Y Gastric Bypass on Metabolic Syndrome, Inflammation, and Insulin Resistance in Super Versus Morbidly Obese Women Iannelli, Antonio; Anty, Rodolphe; Piche, Thierry Obesity Surgery, Vol. 19, Issue 5 https://doi.org/10.1007/s11695-008-9764-8	journal	November 2008
Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention Liu, Ruixin; Hong, Jie; Xu, Xiaoqiang Nature Medicine, Vol. 23, Issue 7 https://doi.org/10.1038/nm.4358	journal	June 2017
MetaboliteDetector: Comprehensive Analysis Tool for Targeted and Nontargeted GC/MS Based Metabolome Analysis Hiller, Karsten; Hangebrauk, Jasper; Jäger, Christian Analytical Chemistry, Vol. 81, Issue 9 https://doi.org/10.1021/ac802689c	journal	May 2009
Human Genetics Shape the Gut Microbiome Goodrich, Julia K.; Waters, Jillian L.; Poole, Angela C. Cell, Vol. 159, Issue 4 https://doi.org/10.1016/j.cell.2014.09.053	journal	November 2014
Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters Graessler, J.; Qin, Y.; Zhong, H. The Pharmacogenomics Journal, Vol. 13, Issue 6 https://doi.org/10.1038/tpj.2012.43	journal	October 2012
Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota Palleja, Albert; Kashani, Alireza; Allin, Kristine H. Genome Medicine, Vol. 8, Issue 1 https://doi.org/10.1186/s13073-016-0312-1	journal	June 2016
New Insights on Bariatric Surgery Outcomes Ikramuddin, Sayeed; Livingston, Edward H. JAMA, Vol. 310, Issue 22 https://doi.org/10.1001/jama.2013.280927	journal	December 2013
A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance Newgard, Christopher B.; An, Jie; Bain, James R. Cell Metabolism, Vol. 9, Issue 6 https://doi.org/10.1016/j.cmet.2009.05.001	journal	June 2009
Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids Nilsson, Niclas E.; Kotarsky, Knut; Owman, Christer Biochemical and Biophysical Research Communications, Vol. 303, Issue 4 https://doi.org/10.1016/s0006-291x(03)00488-1	journal	April 2003
Gastric bypass bariatric surgery in patients undergoing allogeneic hematopoietic stem cell transplantation warrants special considerations Gergis, Usama; Reich-Slotky, Ronit; Abdulahad, Brenda Bone Marrow Transplantation, Vol. 55, Issue 11 https://doi.org/10.1038/s41409-020-0922-5	journal	May 2020
Development of nutritional studies in China Zhu, Shankuan European Journal of Clinical Nutrition, Vol. 75, Issue 2 https://doi.org/10.1038/s41430-020-00793-2	journal	November 2020
Oncogenes overexpressed in metastatic oral cancers from patients with pain: potential pain mediators released in exosomes Bhattacharya, Aditi; Janal, Malvin N.; Veeramachaneni, Ratna Scientific Reports, Vol. 10, Issue 1 https://doi.org/10.1038/s41598-020-71298-y	journal	September 2020
Infant gut microbiota characteristics generally do not modify effects of lipid-based nutrient supplementation on growth or inflammation: secondary analysis of a randomized controlled trial in Malawi Hughes, Riley L.; Arnold, Charles D.; Young, Rebecca R. Scientific Reports, Vol. 10, Issue 1 https://doi.org/10.1038/s41598-020-71922-x	journal	September 2020
Environmental factors shape the epiphytic bacterial communities of Gracilariopsis lemaneiformis Pei, Pengbing; Aslam, Muhammad; Du, Hong Scientific Reports, Vol. 11, Issue 1 https://doi.org/10.1038/s41598-021-87977-3	journal	April 2021
Surgically Induced Changes in Gut Microbiome and Hedonic Eating as Related to Weight Loss: Preliminary Findings in Obese Women Undergoing Bariatric Surgery Sanmiguel, Claudia P.; Jacobs, Jonathan; Gupta, Arpana Psychosomatic Medicine, Vol. 79, Issue 8 https://doi.org/10.1097/psy.0000000000000494	journal	January 2017
Mucosa-Associated Bacteria in the Human Gastrointestinal Tract Are Uniformly Distributed along the Colon and Differ from the Community Recovered from Feces Zoetendal, E. G.; von Wright, A.; Vilpponen-Salmela, T. Applied and Environmental Microbiology, Vol. 68, Issue 7 https://doi.org/10.1128/aem.68.7.3401-3407.2002	journal	July 2002
Intestinal Dysbiosis and Depletion of Butyrogenic Bacteria in Clostridium difficile Infection and Nosocomial Diarrhea Antharam, V. C.; Li, E. C.; Ishmael, A. Journal of Clinical Microbiology, Vol. 51, Issue 9 https://doi.org/10.1128/jcm.00845-13	journal	June 2013
Bile salt biotransformations by human intestinal bacteria Ridlon, Jason M.; Kang, Dae-Joong; Hylemon, Phillip B. Journal of Lipid Research, Vol. 47, Issue 2 https://doi.org/10.1194/jlr.r500013-jlr200	journal	November 2005
Gut microbiota controls adipose tissue expansion, gut barrier and glucose metabolism: novel insights into molecular targets and interventions using prebiotics Geurts, L.; Neyrinck, A. M.; Delzenne, N. M. Beneficial Microbes, Vol. 5, Issue 1 https://doi.org/10.3920/bm2012.0065	journal	March 2014
Assessment of bacterial diversity in breast milk using culture-dependent and culture-independent approaches T., Jost,; C., Lacroix,; C., Braegger, ETH Zurich https://doi.org/10.3929/ethz-b-000072052	text	January 2013

Cited By (2)

Methanethiol and Dimethylsulfide Cycling in Stiffkey Saltmarsh Carrión, Ornella; Pratscher, Jennifer; Richa, Kumari Frontiers in Microbiology, Vol. 10 https://doi.org/10.3389/fmicb.2019.01040	journal	May 2019
Maturation trade-offs in octopus females and their progeny: energy, digestion and defence indicators Olivares, Alberto; Rodríguez-Fuentes, Gabriela; Mascaró, Maite PeerJ, Vol. 7 https://doi.org/10.7717/peerj.6618	journal	April 2019

Similar Records

Distinctive microbiomes and metabolites linked with weight loss after gastric bypass, but not gastric banding

Journal Article · Fri May 26 00:00:00 EDT 2017 · The ISME Journal · OSTI ID:1607642

Ilhan, Zehra Esra; DiBaise, John K.; Isern, Nancy G.; +6 more

Light-Stress Influences the Composition of the Murine Gut Microbiome, Memory Function, and Plasma Metabolome

Journal Article · Fri Oct 18 00:00:00 EDT 2019 · Frontiers in Molecular Biosciences · OSTI ID:1607642

Kim, Young -Mo; Snijders, Antoine M.; Brislawn, Colin J.; +6 more

Systematic Analysis of Impact of Sampling Regions and Storage Methods on Fecal Gut Microbiome and Metabolome Profiles

Journal Article · Wed Jan 08 00:00:00 EST 2020 · mSphere · OSTI ID:1607642

Liang, Yali; Dong, Tianyu; Chen, Minjian; +9 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
gastric bypass
gut metabolome
bile acids
mucosa-associated microbiome
lumenassociated microbiome
fermentation

Title: Temporospatial shifts in the human gut microbiome and metabolome after gastric bypass surgery

Citation Formats

References (74)

Cited By (2)

Similar Records

Related Subjects