skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein

Journal Article · · Nat. Struct. Mol. Biol.

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
National Institutes of Health (NIH)
OSTI ID:
1605436
Journal Information:
Nat. Struct. Mol. Biol., Vol. 27, Issue 02, 2020
Country of Publication:
United States
Language:
ENGLISH

References (54)

Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding journal June 2019
Structure of the Cdc48 segregase in the act of unfolding an authentic substrate journal June 2019
Mechanisms of Sec61/SecY-Mediated Protein Translocation Across Membranes journal June 2012
Clarifying the supercomplex: the higher-order organization of the mitochondrial electron transport chain journal October 2017
Mitochondrial Respiratory-Chain Diseases journal June 2003
Structural Basis of Resistance to Anti-Cytochrome bc1 Complex Inhibitors: Implication for Drug Improvement journal February 2014
Crystal Structure of the Cytochrome bc 1 Complex from Bovine Heart Mitochondria journal July 1997
Mitochondrial proteins: from biogenesis to functional networks journal January 2019
Late-Stage Maturation of the Rieske Fe/S Protein: Mzm1 Stabilizes Rip1 but Does Not Facilitate Its Translocation by the AAA ATPase Bcs1 journal August 2012
Bcs1, a AAA protein of the mitochondria with a role in the biogenesis of the respiratory chain journal August 2012
Surface-modulated motion switch: Capture and release of iron-sulfur protein in the cytochrome bc1 complex journal August 2006
Function and biogenesis of iron–sulphur proteins journal August 2009
Mutational analysis of assembly and function of the iron-sulfur protein of the cytochromebc 1 complex inSaccharomyces cerevisiae journal June 1993
Bcs1p, an AAA-family member, is a chaperone for the assembly of the cytochrome bc1 complex journal October 1999
BCS1, a novel gene required for the expression of functional Rieske iron-sulfur protein in Saccharomyces cerevisiae. journal November 1992
AAA+ superfamily ATPases: common structure-diverse function journal July 2001
Internal targeting signal of the BCS1 protein: a novel mechanism of import into mitochondria. journal February 1996
Identification and Characterization of Human cDNAs Specific to BCS1, PET112, SCO1, COX15, and COX11, Five Genes Involved in the Formation and Function of the Mitochondrial Respiratory Chain journal December 1998
Clinical and diagnostic characteristics of complex III deficiency due to mutations in the BCS1L gene: Complex III Deficiency and BCS1L Mutations journal April 2003
Impaired complex III assembly associated with BCS1L gene mutations in isolated mitochondrial encephalopathy journal April 2007
Protein Structure Comparison by Alignment of Distance Matrices journal September 1993
Functional Analysis of Yeast bcs1 Mutants Highlights the Role of Bcs1p-Specific Amino Acids in the AAA Domain journal May 2009
A Pathway of Protein Translocation in Mitochondria Mediated by the AAA-ATPase Bcs1 journal October 2011
Chaperone–usher pathways: diversity and pilus assembly mechanism journal April 2012
The twin-arginine translocation (Tat) protein export pathway journal June 2012
Structure of the Cytochrome b6f Complex of Oxygenic Photosynthesis: Tuning the Cavity journal November 2003
Phylogenetic analysis of AAA proteins journal April 2004
Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104 journal June 2017
Structures and operating principles of the replisome journal January 2019
Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome journal November 2018
Substrate-engaged 26 S proteasome structures reveal mechanisms for ATP-hydrolysis–driven translocation journal October 2018
The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets journal November 2017
Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7 journal January 2019
Missense Mutations in the BCS1L Gene as a Cause of the Björnstad Syndrome journal February 2007
Clinical spectrum of BCS1L Mitopathies and their underlying structural relationships journal December 2018
Measurement of protein using bicinchoninic acid journal October 1985
An improved assay for nanomole amounts of inorganic phosphate journal November 1979
Assay of inorganic and organic phosphorus in the 0.1–5 nanomole range journal February 1975
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
Molecular replacement with MOLREP journal December 2009
Refinement of Macromolecular Structures by the Maximum-Likelihood Method journal May 1997
The CCP4 suite programs for protein crystallography journal September 1994
PHENIX : building new software for automated crystallographic structure determination journal October 2002
Self-assembled monolayers improve protein distribution on holey carbon cryo-EM supports journal November 2014
MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy journal February 2017
Gctf: Real-time CTF determination and correction journal January 2016
New tools for automated high-resolution cryo-EM structure determination in RELION-3 journal November 2018
MonoRes: Automatic and Accurate Estimation of Local Resolution for Electron Microscopy Maps journal February 2018
Automatic local resolution-based sharpening of cryo-EM maps journal August 2019
UCSF Chimera?A visualization system for exploratory research and analysis journal January 2004
Infantile mitochondrial encephalomyopathy with unusual phenotype caused by a novel BCS1L mutation in an isolated complex III-deficient patient journal February 2009
GRACILE Syndrome, a Lethal Metabolic Disorder with Iron Overload, Is Caused by a Point Mutation in BCS1L journal October 2002
A mutant mitochondrial respiratory chain assembly protein causes complex III deficiency in patients with tubulopathy, encephalopathy and liver failure journal July 2001
The GRACILE mutation introduced into Bcs1l causes postnatal complex III deficiency: A viable mouse model for mitochondrial hepatopathy journal December 2010