skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: HIV vaccine delayed boosting increases Env variable region 2–specific antibody effector functions

Authors:
ORCiD logo; ; ; ; ; ; ORCiD logo; ; ; ; ORCiD logo; ORCiD logo; ; ; ; ORCiD logo; ORCiD logo; ; ; more »; ORCiD logo; ORCiD logo; ; ; ; ; ; ; ; ; ; ; ; ORCiD logo; ; ORCiD logo; ; ; ; ORCiD logo; ; ORCiD logo; « less
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
DOE - BASIC ENERGY SCIENCES
OSTI Identifier:
1600830
Resource Type:
Journal Article
Journal Name:
JCI Insight
Additional Journal Information:
Journal Volume: 5; Journal Issue: 2; Journal ID: ISSN 2379-3708
Publisher:
American Society for Clinical Investigation
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Easterhoff, David, Pollara, Justin, Luo, Kan, Janus, Benjamin, Gohain, Neelakshi, Williams, LaTonya D., Tay, Matthew Zirui, Monroe, Anthony, Peachman, Kristina, Choe, Misook, Min, Susie, Lusso, Paolo, Zhang, Peng, Go, Eden P., Desaire, Heather, Bonsignori, Mattia, Hwang, Kwan-Ki, Beck, Charles, Kakalis, Matina, O’Connell, Robert J., Vasan, Sandhya, Kim, Jerome H., Michael, Nelson L., Excler, Jean-Louis, Robb, Merlin L., Rerks-Ngarm, Supachai, Kaewkungwal, Jaranit, Pitisuttithum, Punnee, Nitayaphan, Sorachai, Sinangil, Faruk, Tartaglia, James, Phogat, Sanjay, Wiehe, Kevin, Saunders, Kevin O., Montefiori, David C., Tomaras, Georgia D., Moody, M. Anthony, Arthos, James, Rao, Mangala, Joyce, M. Gordon, Ofek, Gilad A., Ferrari, Guido, and Haynes, Barton F. HIV vaccine delayed boosting increases Env variable region 2–specific antibody effector functions. United States: N. p., 2020. Web. doi:10.1172/jci.insight.131437.
Easterhoff, David, Pollara, Justin, Luo, Kan, Janus, Benjamin, Gohain, Neelakshi, Williams, LaTonya D., Tay, Matthew Zirui, Monroe, Anthony, Peachman, Kristina, Choe, Misook, Min, Susie, Lusso, Paolo, Zhang, Peng, Go, Eden P., Desaire, Heather, Bonsignori, Mattia, Hwang, Kwan-Ki, Beck, Charles, Kakalis, Matina, O’Connell, Robert J., Vasan, Sandhya, Kim, Jerome H., Michael, Nelson L., Excler, Jean-Louis, Robb, Merlin L., Rerks-Ngarm, Supachai, Kaewkungwal, Jaranit, Pitisuttithum, Punnee, Nitayaphan, Sorachai, Sinangil, Faruk, Tartaglia, James, Phogat, Sanjay, Wiehe, Kevin, Saunders, Kevin O., Montefiori, David C., Tomaras, Georgia D., Moody, M. Anthony, Arthos, James, Rao, Mangala, Joyce, M. Gordon, Ofek, Gilad A., Ferrari, Guido, & Haynes, Barton F. HIV vaccine delayed boosting increases Env variable region 2–specific antibody effector functions. United States. doi:10.1172/jci.insight.131437.
Easterhoff, David, Pollara, Justin, Luo, Kan, Janus, Benjamin, Gohain, Neelakshi, Williams, LaTonya D., Tay, Matthew Zirui, Monroe, Anthony, Peachman, Kristina, Choe, Misook, Min, Susie, Lusso, Paolo, Zhang, Peng, Go, Eden P., Desaire, Heather, Bonsignori, Mattia, Hwang, Kwan-Ki, Beck, Charles, Kakalis, Matina, O’Connell, Robert J., Vasan, Sandhya, Kim, Jerome H., Michael, Nelson L., Excler, Jean-Louis, Robb, Merlin L., Rerks-Ngarm, Supachai, Kaewkungwal, Jaranit, Pitisuttithum, Punnee, Nitayaphan, Sorachai, Sinangil, Faruk, Tartaglia, James, Phogat, Sanjay, Wiehe, Kevin, Saunders, Kevin O., Montefiori, David C., Tomaras, Georgia D., Moody, M. Anthony, Arthos, James, Rao, Mangala, Joyce, M. Gordon, Ofek, Gilad A., Ferrari, Guido, and Haynes, Barton F. Thu . "HIV vaccine delayed boosting increases Env variable region 2–specific antibody effector functions". United States. doi:10.1172/jci.insight.131437.
@article{osti_1600830,
title = {HIV vaccine delayed boosting increases Env variable region 2–specific antibody effector functions},
author = {Easterhoff, David and Pollara, Justin and Luo, Kan and Janus, Benjamin and Gohain, Neelakshi and Williams, LaTonya D. and Tay, Matthew Zirui and Monroe, Anthony and Peachman, Kristina and Choe, Misook and Min, Susie and Lusso, Paolo and Zhang, Peng and Go, Eden P. and Desaire, Heather and Bonsignori, Mattia and Hwang, Kwan-Ki and Beck, Charles and Kakalis, Matina and O’Connell, Robert J. and Vasan, Sandhya and Kim, Jerome H. and Michael, Nelson L. and Excler, Jean-Louis and Robb, Merlin L. and Rerks-Ngarm, Supachai and Kaewkungwal, Jaranit and Pitisuttithum, Punnee and Nitayaphan, Sorachai and Sinangil, Faruk and Tartaglia, James and Phogat, Sanjay and Wiehe, Kevin and Saunders, Kevin O. and Montefiori, David C. and Tomaras, Georgia D. and Moody, M. Anthony and Arthos, James and Rao, Mangala and Joyce, M. Gordon and Ofek, Gilad A. and Ferrari, Guido and Haynes, Barton F.},
abstractNote = {},
doi = {10.1172/jci.insight.131437},
journal = {JCI Insight},
issn = {2379-3708},
number = 2,
volume = 5,
place = {United States},
year = {2020},
month = {1}
}

Works referenced in this record:

Epitope Mapping of Conformational V2-specific Anti-HIV Human Monoclonal Antibodies Reveals an Immunodominant Site in V2
journal, July 2013


Rare Detection of Antiviral Functions of Polyclonal IgA Isolated from Plasma and Breast Milk Compartments in Women Chronically Infected with HIV-1
journal, January 2019

  • Tay, Matthew Zirui; Kunz, Erika L.; Deal, Aaron
  • Journal of Virology, Vol. 93, Issue 7
  • DOI: 10.1128/JVI.02084-18

Vaccine-Induced IgG Antibodies to V1V2 Regions of Multiple HIV-1 Subtypes Correlate with Decreased Risk of HIV-1 Infection
journal, February 2014


Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection
journal, November 2014

  • Byrareddy, Siddappa N.; Kallam, Brianne; Arthos, James
  • Nature Medicine, Vol. 20, Issue 12
  • DOI: 10.1038/nm.3715

Distinct Mechanisms Regulate Exposure of Neutralizing Epitopes in the V2 and V3 Loops of HIV-1 Envelope
journal, August 2014

  • Upadhyay, C.; Mayr, L. M.; Zhang, J.
  • Journal of Virology, Vol. 88, Issue 21
  • DOI: 10.1128/JVI.02125-14

Human cervicovaginal mucus contains an activity that hinders HIV-1 movement
journal, September 2012

  • Shukair, S. A.; Allen, S. A.; Cianci, G. C.
  • Mucosal Immunology, Vol. 6, Issue 2
  • DOI: 10.1038/mi.2012.87

Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies
journal, March 2017


Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial
journal, April 2012

  • Haynes, Barton F.; Gilbert, Peter B.; McElrath, M. Juliana
  • New England Journal of Medicine, Vol. 366, Issue 14
  • DOI: 10.1056/NEJMoa1113425

REFMAC 5 dictionary: organization of prior chemical knowledge and guidelines for its use
journal, November 2004

  • Vagin, Alexei A.; Steiner, Roberto A.; Lebedev, Andrey A.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12
  • DOI: 10.1107/S0907444904023510

MolProbity: More and better reference data for improved all-atom structure validation: PROTEIN SCIENCE.ORG
journal, November 2017

  • Williams, Christopher J.; Headd, Jeffrey J.; Moriarty, Nigel W.
  • Protein Science, Vol. 27, Issue 1
  • DOI: 10.1002/pro.3330

Early treatment of SIV+ macaques with an α4β7 mAb alters virus distribution and preserves CD4+ T cells in later stages of infection
journal, December 2017

  • Santangelo, P. J.; Cicala, C.; Byrareddy, S. N.
  • Mucosal Immunology, Vol. 11, Issue 3
  • DOI: 10.1038/mi.2017.112

Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2
journal, September 2012

  • Rolland, Morgane; Edlefsen, Paul T.; Larsen, Brendan B.
  • Nature, Vol. 490, Issue 7420
  • DOI: 10.1038/nature11519

Identification of New Regions in HIV-1 gp120 Variable 2 and 3 Loops that Bind to α4β7 Integrin Receptor
journal, December 2015


PHENIX : building new software for automated crystallographic structure determination
journal, October 2002

  • Adams, Paul D.; Grosse-Kunstleve, Ralf W.; Hung, Li-Wei
  • Acta Crystallographica Section D Biological Crystallography, Vol. 58, Issue 11
  • DOI: 10.1107/S0907444902016657

HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis
journal, January 2018

  • Wills, Saintedym; Hwang, Kwan-Ki; Liu, Pinghuang
  • Journal of Virology, Vol. 92, Issue 7
  • DOI: 10.1128/JVI.01552-17

The Thai Phase III HIV Type 1 Vaccine Trial (RV144) Regimen Induces Antibodies That Target Conserved Regions Within the V2 Loop of gp120
journal, November 2012

  • Karasavvas, Nicos; Billings, Erik; Rao, Mangala
  • AIDS Research and Human Retroviruses, Vol. 28, Issue 11
  • DOI: 10.1089/aid.2012.0103

Vaccine-Induced Env V1-V2 IgG3 Correlates with Lower HIV-1 Infection Risk and Declines Soon After Vaccination
journal, March 2014


Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates
journal, February 2017


High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies
journal, June 2009


Cryptic Determinant of α4β7 Binding in the V2 Loop of HIV-1 gp120
journal, September 2014


Vaccine-induced V1V2-specific antibodies control and or protect against infection with HIV, SIV and SHIV
journal, January 2019

  • Zolla-Pazner, Susan; Alvarez, Raymond; Kong, Xiang-Peng
  • Current Opinion in HIV and AIDS, Vol. 14, Issue 4
  • DOI: 10.1097/COH.0000000000000551

Inference of Macromolecular Assemblies from Crystalline State
journal, September 2007


Integrin α 4 β 7 expression on peripheral blood CD4 + T cells predicts HIV acquisition and disease progression outcomes
journal, January 2018


Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand
journal, December 2009

  • Rerks-Ngarm, Supachai; Pitisuttithum, Punnee; Nitayaphan, Sorachai
  • New England Journal of Medicine, Vol. 361, Issue 23
  • DOI: 10.1056/NEJMoa0908492

Comparison of Antibody Responses Induced by RV144, VAX003, and VAX004 Vaccination Regimens
journal, May 2017

  • Karnasuta, Chitraporn; Akapirat, Siriwat; Madnote, Sirinan
  • AIDS Research and Human Retroviruses, Vol. 33, Issue 5
  • DOI: 10.1089/aid.2016.0204

Partially Open HIV-1 Envelope Structures Exhibit Conformational Changes Relevant for Coreceptor Binding and Fusion
journal, October 2018


Randomized, Double-Blind Evaluation of Late Boost Strategies for HIV-Uninfected Vaccine Recipients in the RV144 HIV Vaccine Efficacy Trial
journal, February 2017

  • Rerks-Ngarm, Supachai; Pitisuttithum, Punnee; Excler, Jean-Louis
  • The Journal of Infectious Diseases, Vol. 215, Issue 8
  • DOI: 10.1093/infdis/jix099

Common helical V1V2 conformations of HIV-1 Envelope expose the α4β7 binding site on intact virions
journal, October 2018

  • Wibmer, Constantinos Kurt; Richardson, Simone I.; Yolitz, Jason
  • Nature Communications, Vol. 9, Issue 1
  • DOI: 10.1038/s41467-018-06794-x

HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among Vaccinees
journal, January 2018

  • Yates, Nicole L.; deCamp, Allan C.; Korber, Bette T.
  • Journal of Virology, Vol. 92, Issue 8
  • DOI: 10.1128/JVI.01843-17

Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV
journal, December 2013

  • Roederer, Mario; Keele, Brandon F.; Schmidt, Stephen D.
  • Nature, Vol. 505, Issue 7484
  • DOI: 10.1038/nature12893

Coot model-building tools for molecular graphics
journal, November 2004

  • Emsley, Paul; Cowtan, Kevin
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132
  • DOI: 10.1107/S0907444904019158

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target
journal, September 2009


Blocking α 4 β 7 integrin binding to SIV does not improve virologic control
journal, September 2019


Functional Antibody Response Against V1V2 and V3 of HIV gp120 in the VAX003 and VAX004 Vaccine Trials
journal, January 2018

  • Balasubramanian, Preetha; Williams, Constance; Shapiro, Mariya B.
  • Scientific Reports, Vol. 8, Issue 1
  • DOI: 10.1038/s41598-017-18863-0

HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells
journal, February 2008

  • Arthos, James; Cicala, Claudia; Martinelli, Elena
  • Nature Immunology, Vol. 9, Issue 3
  • DOI: 10.1038/ni1566

Human anti-V2 monoclonal antibody that neutralizes primary but not laboratory isolates of human immunodeficiency virus type 1.
journal, January 1994


High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses
journal, July 2011

  • Pollara, Justin; Hart, Lydia; Brewer, Faraha
  • Cytometry Part A, Vol. 79A, Issue 8
  • DOI: 10.1002/cyto.a.21084

PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925

Protection against HIV Acquisition in the RV144 Trial
journal, July 2017


Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses
journal, August 2016


Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation
journal, April 2014


Monoclonal Antibodies Specific for the V2, V3, CD4-Binding Site, and gp41 of HIV-1 Mediate Phagocytosis in a Dose-Dependent Manner
journal, January 2017

  • Musich, Thomas; Li, Liuzhe; Liu, Lily
  • Journal of Virology, Vol. 91, Issue 8
  • DOI: 10.1128/JVI.02325-16

Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys
journal, January 2012

  • Barouch, Dan H.; Liu, Jinyan; Li, Hualin
  • Nature, Vol. 482, Issue 7383
  • DOI: 10.1038/nature10766

The Role of Integrin α4β7 in HIV Pathogenesis and Treatment
journal, February 2018


Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies
journal, July 2015


Glycosylation Site-Specific Analysis of Clade C HIV-1 Envelope Proteins
journal, September 2009

  • Go, Eden P.; Chang, Qing; Liao, Hua-Xin
  • Journal of Proteome Research, Vol. 8, Issue 9, p. 4231-4242
  • DOI: 10.1021/pr9002728

Antibody to the gp120 V1/V2 Loops and CD4 + and CD8 + T Cell Responses in Protection from SIV mac251 Vaginal Acquisition and Persistent Viremia
journal, November 2014

  • Gordon, Shari N.; Doster, Melvin N.; Kines, Rhonda C.
  • The Journal of Immunology, Vol. 193, Issue 12
  • DOI: 10.4049/jimmunol.1401504

Comparison of HPLC/ESI-FTICR MS versus MALDI-TOF/TOF MS for glycopeptide analysis of a highly glycosylated HIV envelope glycoprotein
journal, August 2008

  • Irungu, Janet; Go, Eden P.; Zhang, Ying
  • Journal of the American Society for Mass Spectrometry, Vol. 19, Issue 8
  • DOI: 10.1016/j.jasms.2008.05.010

Risk behaviour and time as covariates for efficacy of the HIV vaccine regimen ALVAC-HIV (vCP1521) and AIDSVAX B/E: a post-hoc analysis of the Thai phase 3 efficacy trial RV 144
journal, July 2012

  • Robb, Merlin L.; Rerks-Ngarm, Supachai; Nitayaphan, Sorachai
  • The Lancet Infectious Diseases, Vol. 12, Issue 7
  • DOI: 10.1016/S1473-3099(12)70088-9

Functional Implications of the Binding Mode of a Human Conformation-Dependent V2 Monoclonal Antibody against HIV
journal, January 2014

  • Spurrier, B.; Sampson, J.; Gorny, M. K.
  • Journal of Virology, Vol. 88, Issue 8
  • DOI: 10.1128/JVI.03153-13

Specificity and affinity of human Fcγ receptors and their polymorphic variants for human IgG subclasses
journal, April 2009