skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor


Citation Formats

Dussupt, Vincent, Sankhala, Rajeshwer S., Gromowski, Gregory D., Donofrio, Gina, De La Barrera, Rafael A., Larocca, Rafael A., Zaky, Weam, Mendez-Rivera, Letzibeth, Choe, Misook, Davidson, Edgar, McCracken, Michael K., Brien, James D., Abbink, Peter, Bai, Hongjun, Bryan, Aubrey L., Bias, Candace Hope, Berry, Irina Maljkovic, Botero, Nubia, Cook, Tanya, Doria-Rose, Nicole A., Escuer, Ariadna Grinyo i, Frimpong, Justice Akuoku, Geretz, Aviva, Hernandez, Mayda, Hollidge, Bradley S., Jian, Ningbo, Kabra, Kareem, Leggat, David J., Liu, Jinyan, Pinto, Amelia K., Rutvisuttinunt, Wiriya, Setliff, Ian, Tran, Ursula, Townsley, Samantha, Doranz, Benjamin J., Rolland, Morgane, McDermott, Adrian B., Georgiev, Ivelin S., Thomas, Rasmi, Robb, Merlin L., Eckels, Kenneth H., Barranco, Elizabeth, Koren, Michael, Smith, Darci R., Jarman, Richard G., George, Sarah L., Stephenson, Kathryn E., Barouch, Dan H., Modjarrad, Kayvon, Michael, Nelson L., Joyce, M. Gordon, Krebs, Shelly J., SLUHSC), NIH), Harvard-Med), Walter Reed), and Vanderbilt-MED). Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor. United States: N. p., 2020. Web. doi:10.1038/s41591-019-0746-2.
Dussupt, Vincent, Sankhala, Rajeshwer S., Gromowski, Gregory D., Donofrio, Gina, De La Barrera, Rafael A., Larocca, Rafael A., Zaky, Weam, Mendez-Rivera, Letzibeth, Choe, Misook, Davidson, Edgar, McCracken, Michael K., Brien, James D., Abbink, Peter, Bai, Hongjun, Bryan, Aubrey L., Bias, Candace Hope, Berry, Irina Maljkovic, Botero, Nubia, Cook, Tanya, Doria-Rose, Nicole A., Escuer, Ariadna Grinyo i, Frimpong, Justice Akuoku, Geretz, Aviva, Hernandez, Mayda, Hollidge, Bradley S., Jian, Ningbo, Kabra, Kareem, Leggat, David J., Liu, Jinyan, Pinto, Amelia K., Rutvisuttinunt, Wiriya, Setliff, Ian, Tran, Ursula, Townsley, Samantha, Doranz, Benjamin J., Rolland, Morgane, McDermott, Adrian B., Georgiev, Ivelin S., Thomas, Rasmi, Robb, Merlin L., Eckels, Kenneth H., Barranco, Elizabeth, Koren, Michael, Smith, Darci R., Jarman, Richard G., George, Sarah L., Stephenson, Kathryn E., Barouch, Dan H., Modjarrad, Kayvon, Michael, Nelson L., Joyce, M. Gordon, Krebs, Shelly J., SLUHSC), NIH), Harvard-Med), Walter Reed), & Vanderbilt-MED). Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor. United States. doi:10.1038/s41591-019-0746-2.
Dussupt, Vincent, Sankhala, Rajeshwer S., Gromowski, Gregory D., Donofrio, Gina, De La Barrera, Rafael A., Larocca, Rafael A., Zaky, Weam, Mendez-Rivera, Letzibeth, Choe, Misook, Davidson, Edgar, McCracken, Michael K., Brien, James D., Abbink, Peter, Bai, Hongjun, Bryan, Aubrey L., Bias, Candace Hope, Berry, Irina Maljkovic, Botero, Nubia, Cook, Tanya, Doria-Rose, Nicole A., Escuer, Ariadna Grinyo i, Frimpong, Justice Akuoku, Geretz, Aviva, Hernandez, Mayda, Hollidge, Bradley S., Jian, Ningbo, Kabra, Kareem, Leggat, David J., Liu, Jinyan, Pinto, Amelia K., Rutvisuttinunt, Wiriya, Setliff, Ian, Tran, Ursula, Townsley, Samantha, Doranz, Benjamin J., Rolland, Morgane, McDermott, Adrian B., Georgiev, Ivelin S., Thomas, Rasmi, Robb, Merlin L., Eckels, Kenneth H., Barranco, Elizabeth, Koren, Michael, Smith, Darci R., Jarman, Richard G., George, Sarah L., Stephenson, Kathryn E., Barouch, Dan H., Modjarrad, Kayvon, Michael, Nelson L., Joyce, M. Gordon, Krebs, Shelly J., SLUHSC), NIH), Harvard-Med), Walter Reed), and Vanderbilt-MED). Tue . "Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor". United States. doi:10.1038/s41591-019-0746-2.
@article{osti_1600829,
title = {Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor},
author = {Dussupt, Vincent and Sankhala, Rajeshwer S. and Gromowski, Gregory D. and Donofrio, Gina and De La Barrera, Rafael A. and Larocca, Rafael A. and Zaky, Weam and Mendez-Rivera, Letzibeth and Choe, Misook and Davidson, Edgar and McCracken, Michael K. and Brien, James D. and Abbink, Peter and Bai, Hongjun and Bryan, Aubrey L. and Bias, Candace Hope and Berry, Irina Maljkovic and Botero, Nubia and Cook, Tanya and Doria-Rose, Nicole A. and Escuer, Ariadna Grinyo i and Frimpong, Justice Akuoku and Geretz, Aviva and Hernandez, Mayda and Hollidge, Bradley S. and Jian, Ningbo and Kabra, Kareem and Leggat, David J. and Liu, Jinyan and Pinto, Amelia K. and Rutvisuttinunt, Wiriya and Setliff, Ian and Tran, Ursula and Townsley, Samantha and Doranz, Benjamin J. and Rolland, Morgane and McDermott, Adrian B. and Georgiev, Ivelin S. and Thomas, Rasmi and Robb, Merlin L. and Eckels, Kenneth H. and Barranco, Elizabeth and Koren, Michael and Smith, Darci R. and Jarman, Richard G. and George, Sarah L. and Stephenson, Kathryn E. and Barouch, Dan H. and Modjarrad, Kayvon and Michael, Nelson L. and Joyce, M. Gordon and Krebs, Shelly J. and SLUHSC) and NIH) and Harvard-Med) and Walter Reed) and Vanderbilt-MED)},
abstractNote = {},
doi = {10.1038/s41591-019-0746-2},
journal = {Nat. Med.},
number = 02, 2020,
volume = 26,
place = {United States},
year = {2020},
month = {2}
}

Works referenced in this record:

Prospects for a Zika Virus Vaccine
journal, February 2017


Zika Virus Vaccine Development
journal, December 2017

  • Morabito, Kaitlyn M.; Graham, Barney S.
  • The Journal of Infectious Diseases, Vol. 216, Issue suppl_10
  • DOI: 10.1093/infdis/jix464

The emergence of Zika virus and its new clinical syndromes
journal, August 2018


Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys
journal, August 2016


Durability and correlates of vaccine protection against Zika virus in rhesus monkeys
journal, December 2017

  • Abbink, Peter; Larocca, Rafael A.; Visitsunthorn, Kittipos
  • Science Translational Medicine, Vol. 9, Issue 420
  • DOI: 10.1126/scitranslmed.aao4163

Vaccine protection against Zika virus from Brazil
journal, June 2016

  • Larocca, Rafael A.; Abbink, Peter; Peron, Jean Pierre S.
  • Nature, Vol. 536, Issue 7617
  • DOI: 10.1038/nature18952

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning
journal, January 2008

  • Tiller, Thomas; Meffre, Eric; Yurasov, Sergey
  • Journal of Immunological Methods, Vol. 329, Issue 1-2
  • DOI: 10.1016/j.jim.2007.09.017

High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies
journal, June 2009


Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
journal, July 2010


Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies
journal, March 2014

  • Doria-Rose, Nicole A.; Schramm, Chaim A.; Gorman, Jason
  • Nature, Vol. 509, Issue 7498
  • DOI: 10.1038/nature13036

Structural basis of potent Zika–dengue virus antibody cross-neutralization
journal, June 2016

  • Barba-Spaeth, Giovanna; Dejnirattisai, Wanwisa; Rouvinski, Alexander
  • Nature, Vol. 536, Issue 7614
  • DOI: 10.1038/nature18938

Structural Basis of Zika Virus-Specific Antibody Protection
journal, August 2016


A Human Bi-specific Antibody against Zika Virus with High Therapeutic Potential
journal, September 2017


Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico
journal, May 2017


Identification of the Fc gamma receptor class I binding site in human IgG through the use of recombinant IgG1/IgG2 hybrid and point-mutated antibodies.
journal, October 1991

  • Chappel, M. S.; Isenman, D. E.; Everett, M.
  • Proceedings of the National Academy of Sciences, Vol. 88, Issue 20
  • DOI: 10.1073/pnas.88.20.9036

A high-throughput shotgun mutagenesis approach to mapping B-cell antibody epitopes
journal, July 2014

  • Davidson, Edgar; Doranz, Benjamin J.
  • Immunology, Vol. 143, Issue 1
  • DOI: 10.1111/imm.12323

The 3.8 A resolution cryo-EM structure of Zika virus
journal, March 2016


Structural insights into the neutralization mechanism of a higher primate antibody against dengue virus: Crystal structure of dengue virus 4 E with Fab 5H2
journal, December 2011

  • Cockburn, Joseph JB; Navarro Sanchez, M. Erika; Goncalvez, Ana P.
  • The EMBO Journal, Vol. 31, Issue 3
  • DOI: 10.1038/emboj.2011.439

Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope
journal, July 2015


Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus
journal, October 2018

  • Renner, Max; Flanagan, Aleksandra; Dejnirattisai, Wanwisa
  • Nature Immunology, Vol. 19, Issue 11
  • DOI: 10.1038/s41590-018-0227-7

Identification of Distinct Antigenic Determinants on Dengue-2 Virus Using Monoclonal Antibodies
journal, May 1982

  • McCown, J. M.; Dalrymple, J. M.; Gentry, M. K.
  • The American Journal of Tropical Medicine and Hygiene, Vol. 31, Issue 3
  • DOI: 10.4269/ajtmh.1982.31.548

Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody
journal, May 2016


Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope
journal, January 2019


Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region
journal, February 2019

  • Rodriguez-Barraquer, Isabel; Costa, Federico; Nascimento, Eduardo J. M.
  • Science, Vol. 363, Issue 6427
  • DOI: 10.1126/science.aav6618

Dengue Virus-Specific and Flavivirus Group Determinants Identified with Monoclonal Antibodies by Indirect Immunofluorescence
journal, July 1982

  • McCown, J. M.; Gentry, M. K.; Brandt, W. E.
  • The American Journal of Tropical Medicine and Hygiene, Vol. 31, Issue 4
  • DOI: 10.4269/ajtmh.1982.31.830

IgBLAST: an immunoglobulin variable domain sequence analysis tool
journal, May 2013

  • Ye, Jian; Ma, Ning; Madden, Thomas L.
  • Nucleic Acids Research, Vol. 41, Issue W1
  • DOI: 10.1093/nar/gkt382

A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus
journal, December 2014

  • Dejnirattisai, Wanwisa; Wongwiwat, Wiyada; Supasa, Sunpetchuda
  • Nature Immunology, Vol. 16, Issue 2
  • DOI: 10.1038/ni.3058

Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
journal, December 2016


A New Quaternary Structure Epitope on Dengue Virus Serotype 2 Is the Target of Durable Type-Specific Neutralizing Antibodies
journal, October 2015


Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice
journal, November 2016

  • Sapparapu, Gopal; Fernandez, Estefania; Kose, Nurgun
  • Nature, Vol. 540, Issue 7633
  • DOI: 10.1038/nature20564

A Phase II, Randomized, Safety and Immunogenicity Study of a Re-Derived, Live-Attenuated Dengue Virus Vaccine in Healthy Adults
journal, January 2013

  • Thomas, Stephen J.; Eckels, Kenneth H.; Carletti, Isabelle
  • The American Journal of Tropical Medicine and Hygiene, Vol. 88, Issue 1
  • DOI: 10.4269/ajtmh.2012.12-0361

Impact of prior flavivirus immunity on Zika virus infection in rhesus macaques
journal, August 2017


Effector Function Activities of a Panel of Mutants of a Broadly Neutralizing Antibody against Human Immunodeficiency Virus Type 1
journal, December 2001


Phaser crystallographic software
journal, July 2007

  • McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D.
  • Journal of Applied Crystallography, Vol. 40, Issue 4
  • DOI: 10.1107/S0021889807021206

Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis
journal, May 2006

  • Strong, M.; Sawaya, M. R.; Wang, S.
  • Proceedings of the National Academy of Sciences, Vol. 103, Issue 21
  • DOI: 10.1073/pnas.0602606103

MolProbity : all-atom structure validation for macromolecular crystallography
journal, December 2009

  • Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1
  • DOI: 10.1107/S0907444909042073

Inference of Macromolecular Assemblies from Crystalline State
journal, September 2007


Monitoring and improving the sensitivity of dengue nested RT-PCR used in longitudinal surveillance in Thailand
journal, February 2015

  • Klungthong, Chonticha; Manasatienkij, Wudtichai; Phonpakobsin, Thipwipha
  • Journal of Clinical Virology, Vol. 63
  • DOI: 10.1016/j.jcv.2014.12.009