skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Structural basis for the activation of PLC-[gamma] isozymes by phosphorylation and cancerassociated mutations

Authors:
; ; ; ; ; ; ;  [1]
  1. UNC
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
NSFNIH
OSTI Identifier:
1600781
Resource Type:
Journal Article
Journal Name:
eLIFE J.
Additional Journal Information:
Journal Volume: 8; Journal Issue: 2019
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Hajicek, Nicole, Keith, Nicholas C., Siraliev-Perez, Edhriz, Temple, Brenda R.S., Huang, Weigang, Zhang, Qisheng, Harden, T. Kendall, and Sondek, John. Structural basis for the activation of PLC-[gamma] isozymes by phosphorylation and cancerassociated mutations. United States: N. p., 2020. Web. doi:10.7554/eLife.51700.
Hajicek, Nicole, Keith, Nicholas C., Siraliev-Perez, Edhriz, Temple, Brenda R.S., Huang, Weigang, Zhang, Qisheng, Harden, T. Kendall, & Sondek, John. Structural basis for the activation of PLC-[gamma] isozymes by phosphorylation and cancerassociated mutations. United States. doi:10.7554/eLife.51700.
Hajicek, Nicole, Keith, Nicholas C., Siraliev-Perez, Edhriz, Temple, Brenda R.S., Huang, Weigang, Zhang, Qisheng, Harden, T. Kendall, and Sondek, John. Thu . "Structural basis for the activation of PLC-[gamma] isozymes by phosphorylation and cancerassociated mutations". United States. doi:10.7554/eLife.51700.
@article{osti_1600781,
title = {Structural basis for the activation of PLC-[gamma] isozymes by phosphorylation and cancerassociated mutations},
author = {Hajicek, Nicole and Keith, Nicholas C. and Siraliev-Perez, Edhriz and Temple, Brenda R.S. and Huang, Weigang and Zhang, Qisheng and Harden, T. Kendall and Sondek, John},
abstractNote = {},
doi = {10.7554/eLife.51700},
journal = {eLIFE J.},
number = 2019,
volume = 8,
place = {United States},
year = {2020},
month = {2}
}

Works referenced in this record:

PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925

The Selectivity of Receptor Tyrosine Kinase Signaling Is Controlled by a Secondary SH2 Domain Binding Site
journal, August 2009


Recurrent PTPRB and PLCG1 mutations in angiosarcoma
journal, March 2014

  • Behjati, Sam; Tarpey, Patrick S.; Sheldon, Helen
  • Nature Genetics, Vol. 46, Issue 4
  • DOI: 10.1038/ng.2921

MolProbity : all-atom structure validation for macromolecular crystallography
journal, December 2009

  • Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1
  • DOI: 10.1107/S0907444909042073

Features and development of Coot
journal, March 2010

  • Emsley, P.; Lohkamp, B.; Scott, W. G.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4
  • DOI: 10.1107/S0907444910007493

Enzymatic assembly of DNA molecules up to several hundred kilobases
journal, April 2009

  • Gibson, Daniel G.; Young, Lei; Chuang, Ray-Yuan
  • Nature Methods, Vol. 6, Issue 5, p. 343-345
  • DOI: 10.1038/nmeth.1318

General and Versatile Autoinhibition of PLC Isozymes
journal, August 2008


Mammalian Phospholipase C
journal, February 2013


Cell Signaling by Receptor Tyrosine Kinases
journal, June 2010


An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation
journal, August 2011

  • Lyon, Angeline M.; Tesmer, Valerie M.; Dhamsania, Vishan D.
  • Nature Structural & Molecular Biology, Vol. 18, Issue 9
  • DOI: 10.1038/nsmb.2095

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB
journal, July 2015

  • Maier, James A.; Martinez, Carmenza; Kasavajhala, Koushik
  • Journal of Chemical Theory and Computation, Vol. 11, Issue 8
  • DOI: 10.1021/acs.jctc.5b00255

Comparative Protein Structure Modeling of Genes and Genomes
journal, June 2000

  • Martí-Renom, Marc A.; Stuart, Ashley C.; Fiser, András
  • Annual Review of Biophysics and Biomolecular Structure, Vol. 29, Issue 1
  • DOI: 10.1146/annurev.biophys.29.1.291

Routine Access to Millisecond Time Scale Events with Accelerated Molecular Dynamics
journal, August 2012

  • Pierce, Levi C. T.; Salomon-Ferrer, Romelia; Augusto F. de Oliveira, Cesar
  • Journal of Chemical Theory and Computation, Vol. 8, Issue 9
  • DOI: 10.1021/ct300284c

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
journal, July 2017

  • Sims, Rebecca; van der Lee, Sven J.; Naj, Adam C.
  • Nature Genetics, Vol. 49, Issue 9
  • DOI: 10.1038/ng.3916

A New Vector for High-Throughput, Ligation-Independent Cloning Encoding a Tobacco Etch Virus Protease Cleavage Site
journal, June 2002

  • Stols, Lucy; Gu, Minyi; Dieckman, Lynda
  • Protein Expression and Purification, Vol. 25, Issue 1
  • DOI: 10.1006/prep.2001.1603

Iterative model building, structure refinement and density modification with the PHENIX AutoBuild wizard
journal, December 2007

  • Terwilliger, Thomas C.; Grosse-Kunstleve, Ralf W.; Afonine, Pavel V.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 64, Issue 1
  • DOI: 10.1107/S090744490705024X

Kinetic Scaffolding Mediated by a Phospholipase C-  and Gq Signaling Complex
journal, October 2010


A Completely Reimplemented MPI Bioinformatics Toolkit with a New HHpred Server at its Core
journal, July 2018

  • Zimmermann, Lukas; Stephens, Andrew; Nam, Seung-Zin
  • Journal of Molecular Biology, Vol. 430, Issue 15
  • DOI: 10.1016/j.jmb.2017.12.007